In the present study,neuroblastoma（SH-SY5 Y）cells were used to investigate the mechanisms mediating the potential protecti......

Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection, cell stress, neuronal diseas......

Prolactin is a polypeptide hormone associated with an extensive variety of biological functions. Among the roles of prol......

Stress response is a cellular widespread mechanism encoded by a common protein program composed by multiple cellular fac......

Spinal cord injury (SCI) research is a very complex field lending to why reviews of SCI literatures can be beneficial to......

SRY-related HMG-box (Sox) transcription factors are known to regulate central nervous system development and are involve......

Autophagy has been shown to play an important role in Parkinson\'s disease.We hypothesized that skin-derived precursor......

Our previous study has shown that the transcription factor Krüppel-like factor 7 (KLF7) promotes peripheral nerve regen......

The recovery of blood circulation following cerebral infarction-associated thrombolysis brings new damage to the brain,w......

Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals an......

内质网应激(endoplasmic reticulum stress,ERS)与帕金森病(Parkinson\'s disease,PD)发展进程密切相关.Apelin是已被证实具有明......

Glycogen synthase kinase-3β (GSK-3β) has been shown to attenuate DNA damage in nerve cells, thereby enhancing neuronal......

Ischemic stroke is the most common type of cerebrovascular disease and is causedby an interruption of blood flow in the ......

Bcl-xL is a pro-survival protein of the Bcl2 family found in the mitochondrial membrane. Bcl-xL supports growth, develop......

Parkinson\'s disease is a neurodegenerative disorder characterized by a combinationof severe motor and non-motor sympt......

We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-like receptors (TLR) ......

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Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central......

MicroRNA-365 (miR-365) is upregulated in the ischemic brain and is involved in oxidative damage in the diabetic rat.Howe......

α-Synuclein is a soluble monomer abundant in the central nervous system.Aggregates of α-synuclein,consisting of higher......

Currently there are no convincing effective treatments for spinal cord injury(SCI),meanwhile,factors that adversely affe......

Ethoxyquin(EQ(1,2-dihydro-6-ethoxy-2,2,4,trimethylqyuinoline))is an antioxidant used in animal foods for over 50 years.I......

Objective Bisphosphonates(BP)is a category of drugs that are used to treat various bone diseases,such as osteoporosis,Pa......

Objective To indicate that heat shock protein 72(HSP72)is involved in the prevention of neuronal injury.Method Zinc sulf......

Purpose Apoptosis of retinal ganglion cells(RGCs)is one of the common pathological features associated with optic nerve ......

Objective Stroke is the third most common cause of death after heart attack and cancer and has profound negative social ......

To investigate the neuroprotective effects of neurotrophin-3(NT-3) expression controlled by five copies of the hypoxia-r......

Methylene blue(MB)was mainly used in the clinical treatment of cyanide poisoning and methemoglobinemia.Currently,the neu......

Preconditioning means that a previous minor insult prepares the body to better withstand a subsequent larger insult.High......

Calorie restriction (CR) not only extends lifespan of organisms but also increases resistance to a variety of age-relate......

Caloric restriction(CR)has been shown to have several health benefits and provides protection against type 2 diabetes,ne......

Deproteinised Calf Blood Injection(DCBI)has been used in neurology as a neuroprotective agent,but little research about ......

Glial cell response to injury has been well documented in the pathogenesis after traumatic brain injury(TBI)and spinal c......

17-β-Estradiol (E2) is a steroid hormone involved in neuroprotection against excitotoxicity and other forms of brain in......

Objective Alzheimers disease(AD)is a progressive neurodegenerative disorder which is still irreversible up to now.The ty......

Aim Shengnai injection (SMI) , a Chinese patent medicine deprived from an ancient Chinese herbal compound Shengmai san, ......

Aim: The tryptophan metabolic enzyme systems of indoleamine 2,3-dioxygenase (IDO) and tryptophanyl-tRNA synthetase (TrpR......

Aim: Previous studies showed that ER-α36, a novel variant of estrogen receptor alpha (ER-α) was widely expressed in br......

Aim: Sildenafil, a phosphodiesterase type 5 inhibitor, has been found to produce functional recovery in ischemic rats by......

Objective: toll-like receptors (TLRs) could mediate innate and adaptive immunity and also could be affected by oxidative......

Background:Oxidative and inflammatory damage have been suggested to play an important role in cerebral ischemic pathogen......

Aim This study is aimed to determine whether SPK2 (Sphingosine kinase2) is involved in isoflurane preconditioning induce......

Aim: Shengnaokang preparation (SP), consisting of fifteen Chinese herbal medicines, has been used for the treatment of c......

Aim: Increasing evidence indicates that oxidative stress plays a key role in the senescent development.NF-E2-related fac......

Objective Several lines of evidences indicated that autophagy was involved in ischemic brain injury.Ischemia/reperfusion......

Objective: Polygonum multiflorum Thunb.is more commonly used in Chinese herbs/constituents (e.g.Kang Zhen Zhi Jing No.1 ......