【摘 要】
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Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals and the community.To date,effective therapy for stroke has been limited by its complex pathological mechanisms.Autophagy refers to an int
【机 构】
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Institute of Pharmacology&Toxicology,College of Pharmaceutical Sciences,Key Laboratory of Medical Ne
论文部分内容阅读
Stroke is considered a leading cause of mortality and neurological disability,which puts a huge burden on individuals and the community.To date,effective therapy for stroke has been limited by its complex pathological mechanisms.Autophagy refers to an intracellular degrading process with the involvement of lysosomes.Autophagy plays a critical role in maintaining the homeostasis and sur-vival of cells by eliminating damaged or non-essential cellular constituents.Increasing evidence support that autophagy protects neuronal cells from ischemic injury.However,under certain circumstances,auto-phagy activation induces cell death and aggravates ischemic brain injury.Diverse naturally derived com-pounds have been found to modulate autophagy and exert neuroprotection against stroke.In the present work,we have reviewed recent advances in naturally derived compounds that regulate autophagy and dis-cussed their potential application in stroke treatment.
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