Aim: Increasing evidence indicates that oxidative stress plays a key role in the senescent development.NF-E2-related factor 2 (Nrf2) is currently considered the master regulator of redox homeostasis through antioxidant response element.Panax japonicus, in which the saponins are proved to make up the active major constituents, is a medicinal plant widely used in folk and traditional medicine for its antioxidative activity.