6-OHDA相关论文
目的:探讨改良的单侧纹状体两点法双靶点注射神经毒素6-羟多巴胺（6-OHDA）制备帕金森病（PD）大鼠模型,对提高制模成功率的可行性。方法:......
第一部分帕金森病小鼠模型制备及疼痛行为学评估目的:通过在小鼠左侧纹状体注射6-羟基多巴（6-OHDA）的方式构建单侧帕金森（parkinson’......
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A novel transgenic zebrafish sensor for screening of potential therapeutic drug for Parkinson diseas
The sensitive tyrosine hydroxylasegreen fluorescent protein (THGFP) transgenic zebrafish was originally developed and ap......
Effects of ginsenoside Rg1 and insulin-like growth factor-Ⅰ on 6-OHDA-induced neurotoxicity in SK-N-
Both ginsenoside Rg1 and insulin-like growth factor-Ⅰ (IGF-Ⅰ) has been reported to exert neurotropic and neuroprotecti......
Neuroprotective effect of porphyra polysaccharide on 6-OHDA-induced cytotoxicity in MES23.5 dopamine
Porphyra polysaccharide could exert diverse biological activities such as immunomodulation, antioxidation and antiaging.......
Neuroprotective mechanism of overexpression of mitochondrial ferritin on dopaminergic SH-SY5Y cell a
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Gene expression profile of 100 Hz electro-acupuncture treatment in 6-hydroxydopamine-induced Parkins
Electro-acupuncture (EA), especially high-frequency EA, has been frequently used as an alternative therapy for Parkinson......
Ndfip1 attenuats 6-OHDA-induced cellular iron accumulation via degradation of DMT1 in dopaminergic c
Nedd4 family interacting protein 1 (Ndfip1), an adaptor protein for Nedd4-mediated ubiquitination, has been found to pla......
Background Nurr1 (nuclear receptor-related factor 1),a transcription factor of the steriod/thyroxin hormone nuclear rece......
目的 动物大脑置管给药可以消除中枢神经即刻给药引起的应激反应和实现重复给药,探索改良大鼠大脑置管方法,并应用于帕金森氏病(PD......
Autophagy is the major intracellular catabolic mechanism by which cytoplasmic materials can be degraded in the lysosome.......
The effects of 6-hydroxy dopamine on refractive development and form-deprivation myopia in C57BL/6 m
There is now mounting evidence implying the involvement of retinal dopamine (DA) in the signaling cascade that leads to ......
Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pa
OBJECTIVE To investigate the neuroprotective role of naringenin and delineate its mechanism of action against 6-hydroxyd......
Experimental study of ginseng Rb fraction, Levodopa and their combination in the treatment of Parkin
Aim of study:Parkinsons disease (PD) is the second most common chronic neurodegenerative disorder,after Alzheimers disea......
目的:探讨帕金森病发病过程中黑质神经元的缺失形式.方法:将6-OHDA立体定向微量注射于右侧内侧前脑束(MFB制备PD大鼠模型,观察大鼠......
Objectives: To investigate whether overexpression of Nurr1 (nuclear receptor-related factor 1) enhances the vulnerabilit......
Elevated iron accumulation and increased divalent metal transporter 1 (DMT1) expression have been reported in the su......
目的研究天然冰片对6-羟基多巴胺(6-OHDA)诱导的PC12细胞损伤的保护作用。方法以6-OHDA建立PC12细胞损伤模型,观察天然冰片对其细......
目的 研究电针对震颤麻痹大鼠行为学及细胞形态学的影响.方法 36只造模成功的雄性SD大鼠按随机数字表法分为模型组、电针组和左旋......
观察经颅重复性低频磁刺激(rTMS)对大鼠纹状体FosB蛋白表达的影响.6-OHDA单侧损毁纹状体边缘区,磁刺激器给予大鼠头部1 Hz,100 mT......
目的 研究6-OHDA损伤PC12细胞CXCR4/12表达的变化.方法 以梯度浓度的6-OHDA处理PC12细胞,光镜观察各组PC12细胞的形态学变化;MTT法......
目的 探讨神经毒素6-羟基多巴胺(6-OHDA)诱导PC12细胞的帕金森(PD)模型中GRP78的表达.方法 在建立6-OHDA诱导PC12细胞帕金森模型的......
帕金森病(Parkinson disease,PD)是一种常见于中老年人的神经系统变性疾病,临床上以静止性震颤、运动迟缓、肌强直和姿势平衡障碍......
目的:帕金森氏病(Parkinson’s disease,PD)是继阿尔茨海默症之后的第二类重要的年龄相关的神经退行性疾病。花生四烯酸(arachidon......
目的观察Ghrelin能否保护人神经母细胞癌细胞(SH-SY5Y细胞)抵抗6-OHDA所致的线粒体损伤和细胞凋亡。方法培养SH-SY5Y细胞,随机分为......
本实验以交感神经化学切除剂6-羟多巴胺(6-OHDA)一次性行幼龄大鼠睾丸内注射,观察到睾丸生精上皮细胞数量减少,出现一些多核巨细胞......
6-羟多巴胺(6-OHDA)于不同部位及不同剂量注射可以造成模拟不同阶段PD的模型鼠,其症状稳定持久,不容易出现神经元功能自行恢复,6-......
目的 建立立体定向手术下6-OHDA黑质毁损的帕金森病恒河猴模型并建立客观评估体系.方法 实验用恒河猴5只,在立体定向技术下以6-OHD......
目的研究使用六羟多巴胺(6-OHDA)化学性阻断交感神经对小鼠脾脏形态原的影响及其抗氧化机制。方法应用组织学、免疫组织化学、MTT......
帕金森病动物模型是研究帕金森病病因、病机、病理、症状体征、神经保护、药物治疗的必备工具。在众多帕金森病动物模型中目前应用......
Activation of Wnt/β-catenin pathway by exogenous Wnt1 exerts protective effects in 6-OHDA treated SH
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Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson’s model through apoptosis and iro
Objective:Parkinson’s disease(PD)is characterized by the loss of dopaminergic neurons in substantia nigra(SN).Our previ......
目的 通过比较自身不表达Nurrl基因的人神经母细胞瘤细胞SK―N―SH和过表达外源性Null基因的SK―N―SH/Nurrl细胞对神经毒素6-羟多......
背景和目的 帕金森病(Parkinsonsdisease，PD)主要病变是中脑黑质多巴胺(DA)能神经元进行性变性消失，导致纹状体系统DA能神经元投......
,Parkin represses 6-hydroxydopamine-induced apoptosis via stabilizing scaffold protein p62 in PC12 c
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目的:研究6-羟基多巴胺(6-Hydroxydopamine, 6-OHDA)诱导的大鼠多巴胺(Dopamine ,DA)能神经元细胞周期素的异常表达、自噬的激活在......
神经营养因子家族是首先被考虑到用于保护多胺能神经元的基因.胶质细胞源神经营养因子(GDNF)由于可以直接作用于神经细胞,并对多巴......
为了明确Nurr1基因在维持DA能神经元存活以及DA能神经元特异性损伤中的作用机制,需要建立良好的细胞模型.本实验利用脂质体基因转......
目的 观察帕金森病进程中不同程度黑质损伤时黑质感觉门控P50和黑质内DA神经元的变化，研究黑质感觉门控P50和不同程度黑质损伤的关......
帕金森病(Pakinsons disease,PD)是以黑质致密部(nigrapars compacta,SNc)多巴胺(Dopamine,DA)能神经元进行性丢失为主要病理特征......
