tamoxifen相关论文
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Tamoxifen Inhibits Inflammatory Pathways and Improves Locomotor Function in Traumatic Spinal Cord In
In this study the potential therapeutic effect of tamoxifen was explored on traumatic SCI in rats....
The relationship between the CYP2D6 polymorphisms and endoxifen serum concentration in Chinese breas
Objective Background Endoxifen is the major mediator of tamoxifen effect and low endoxifen levels may be associated with......
Estrogen Receptor Variant ER-α36 Promotes Tamoxifen Agonist action in Glioblastomas through autophag
Glioblastoma(GBM)is a highly infiltrative and incurable primary brain tumor.Despite aggressive therapy,patients with GBM......
ER-α36, a novel variant of ER-α, was involved in the progression and acquired tamoxifen-resistance i
Aim: It is established that glioma, the most common form of primary brain tumor, possess the characteristic of high inci......
Influence of the focal ischemia reperfusion on a novel estrogen receptor alpha 36 and correlated est
Aim: Previous studies showed that ER-α36, a novel variant of estrogen receptor alpha (ER-α) was widely expressed in br......
Purpose: Tamoxifen (TAM) is most commonly prescribed for patients with hormone-sensitive breast cancer and exerts agonis......
目的：乳腺癌是严重威胁妇女健康的主要恶性肿瘤，内分泌治疗是乳腺癌综合治疗的主要手段之一.Tamoxifen(TAM)一直是绝经前乳腺癌内分......
Tamoxifen is a potent antioxidant modulator for sperm quality in patients with idiopathic oligoasthe
Objective: To explore the new mechanisms of tamoxifen(TAM)in the treatment for patients with idiopathic oligoasthenosper......
Glioblastoma, the most common form of primary malignant brain tumor, is known for its high incidence rate and low respon......
Objective: This study was designed to evaluate the efficacy of combination therapy of Tamoxifen,L-carnitine and daily PD......
Objective: This study was designed to evaluate the efficacy of combination therapy of Tamoxifen,L-carnitine and daily PD......
Background: Acute liver failure (ALF) is a severe hepatic syndrome in clinic, which signifies by acute hepatic injury, a......
目的 探讨ER-α66和ER-α 36在乳腺癌细胞中共表达增强Tamoxifen抵抗的作用及其机制。方法 Western blot对G418筛选的SKBR3/ER-α6......
Radiation Therapy and Tamoxifen after Breast-conserving Surgery: Updated Results of a 2 × 2 Randomis
"To study the role of radiotherapy and tamoxifen after breast-conserving surgery (BCS) in patients with a favourable pr......
PTEN gene mutation and expression of mRNA in tamoxifen-Stimulated Endometrium in Postmenopausal Brea
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目的探索Tamoxifen用于治疗皮肤瘢痕挛缩的可能性.方法将人真皮成纤维细胞种植于Ⅰ型胶原构成的胶原网格内培养,加入1～50 μmol/L的......
目的探讨诺雷德联合他莫昔芬内分泌治疗对早期乳腺癌雌激素(E2)、胰岛素样生长因子1(IGF-1)、E-钙黏蛋白(E-cadherin)表达及预后的......
目的探究长链非编码RNA（LncRNA）LINC00672对乳腺癌细胞他莫昔芬（tamoxifen，TAM）敏感性的影响及其相关机制。方法以人乳腺癌细胞MCF-7为......
MicroRNAs(miRNAs)typically bind to unstructured miRNA-binding sites in target RNAs,leading to a mutual repression of......
Tamoxifenresistance leads to lethality in a substantial fraction of estrogen positivebreast cancer patients.Here,we ......
《英国医学杂志》第284卷第6319期第844页(1982年)刊载James Owen Drife文章,健康男子的精子计数可以在每月,甚至在每周内有很大......
精子减少是男性不孕症的常见原因,由于精子发生是性激素依赖过程,通常认为具有特效的激素治疗能改善男性不孕症。本文对19例年龄......
中期孕鼠在他莫昔芬作用下，其颌下腺，血清中ＥＧＦ含量下降，胎盘中ＥＧＦ受体结合位点数下降以及它的ｍＲＮＡ表达受到抑制，再次证实了他莫昔芬抑制雌激素诱......
利用改进的葡聚糖活性炭饱和分析法，对卵巢切除大鼠注射雌二醇或同时注射雌二醇和三苯氧胺后６ｈ和６４ｄ，进行子宫ＥＲ含量测定，发现，Ｅ＋Ｔ组比Ｅ组的ＥＲ值小并......
Klopper 等于1971年首次报导使用雌激素对抗剂 tamoxifen(1[P-B 二甲基氨基乙氧酚]-1,2二酚-1-烯的逆式异构体)诱发排卵。以后也......
最近由三苯乙烯系列物合成Tamoxifen,它是(对-B-二甲氨乙氧苯基)-1,2-二苯基丁-1-烯(P-B-dime thylaminoe Thoxy-phenyl)-1,2-dip......
从广义来说抗雌激素药为一组具有对抗雌激素活力的物质,其中有些物质并不直接对抗,而是改变雌激素的作用,例如雄激素和孕激素。有......
大家公认黄体期功能主要依赖于排卵前及排卵期前后滤泡情况。虽然有些报告论及对月经周期正常的(包括怀疑黄体期不足者)不孕妇女......
抗雌激素制剂可使乳腺癌肿块明显缩小。研究证明,约50%的卵巢癌雌激素受体阳性。为评价抗雌激素治疗对晚期耐药的卵巢癌是否有相......
近年,乳房囊性增生病(乳腺病)在我国有明显上升趋势,与之相关的乳腺癌已成为威胁妇女健康的最主要恶性肿瘤。目前对该病尚缺乏满......
三苯氧胺(tamoxifen)作为雌激素拮抗剂,用于治疗乳腺癌以减少复发,但也有报道其具有部分雌激素受体兴奋作用。4例乳腺癌切除术后......
与克罗米芬(CC)诱发排卵±高效率相比,其妊娠率并未达到期望的频率。近有报道将CC和他莫昔芬(tamoxifen TMX)合用可提高那些对CC......
雌激素减少绝经后的骨转换,甚至在存在原发性甲旁亢时也是如此,其机制可能与FTH-1,25(OH)_2D轴有关。乳癌与原发性甲旁亢常并存。......
目的 探讨雌激素与抗雌激素制剂对子宫内膜癌细胞化疗效应的影响。方法 采用细胞凋亡ELISA方法检测雌激素、三苯氧胺与阿霉素相互......
雌激素替代疗法 (ERT)是绝经后骨质疏松的首选治疗方案 ,但是长期应用后带来的子宫内膜增生、乳腺癌发生率上升等副作用也一直困扰......
Expression of Insulin-like Growth Factor-I in Uterusis Ovarian Steroid Dependent:An in situ Immunohi
Objective To study the immunohistochemical localization of insulin-like growth factor-I (IGF-I) in rats’uteri to determ......
目的:建立超高效液相色谱-串联质谱法测定大鼠血浆中他莫西芬及其2种主要活性代谢物的浓度,并应用于大鼠口服他莫西芬后的药动学研......
The role of hormone therapy in the treatment of ovarian cancer is not clear. Data on the efficacy and safety of antiestr......
在工业化国家,高血压是主要疾病之一,也是主要的人群死亡原因。一氧化氮是一个重要的舒张血管和调节血压的血管因子。一氧化氮主要......
We report a case of severe, refractory gastrointestinal(GI) bleeding in a patient with hereditary hemorrhagic telangiect......
OBJECTIVE: To evaluate the effect of tamoxifen (TAM) combined with a somatostatin analogue,octretide (OCT) on advanced ......
他莫昔芬(tamoxifen)已成为一种广泛用于妇女早期及晚期乳腺癌治疗的激素类药。目前,他莫昔芬除了用于癌症治疗外,国际乳腺癌干预......
目的探讨维生素D3 (vitamin D3,VitD3)对乳腺癌裸鼠移植模型的治疗作用. 方法裸鼠皮下接种MCF-7乳腺癌细胞,建立乳腺癌裸鼠移植模......
Objective: To study the effects of raloxifene on the growth of the human ovarian cancer cell line Skov3 and on the expre......
