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Objective To indicate that heat shock protein 72(HSP72)is involved in the prevention of neuronal injury.Method Zinc sulfate and quercetin induced and inhibited the expression of HSP72,respectively.Intraperitoneal injections of zinc sulfate,SP600125(c-Jun N-terminal kinase inhibitor),or quercetin were performed on retinal ganglion cells in a Wistar rat model of chronic ocular hypertension.