alpha-synuclein相关论文
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhi
Autophagy has been shown to play an important role in Parkinson\'s disease.We hypothesized that skin-derived precursor......
Parkinson\'s disease is a neurodegenerative disorder characterized by a combinationof severe motor and non-motor sympt......
Progressive accumulation of α-synuclein is a key step to pathological development of Parkinsons disease and dementia wi......
Parkinsons disease patients exhibit progressive spreading of aggregated α-synuclein in the nervous system.Recent data s......
(-) Schisandrin B enhances ATG16L1-mediated autophagy and promotes alpha-synuclein degradation in ne
Autophagy is a major cellular machinery for the degradation of aggregated proteins via lysosome.Autophagy deregulation i......
Non-human primate models of motor and non-motor symptoms and molecular pathology of Parkinson’s dise
Non-human primate models of Parkinsons disease(PD)have had a tremendous impact on the drug development process over the ......
目的评价丙泊酚对帕金森病(PD)小鼠黑质炎症反应的影响及其与α-突触核蛋白(α-syn)表达的关系。方法SPF级健康雄性C57BL/6小鼠33......
Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically rele
N-acetylated α-synuclein (αSyn) has long been established as an intrinsically disordered protein associated with a dys......
For more than a decade numerous evidence has been reported on the mechanisms of toxicity of α-synuclein (αS) oligomers......
Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in
...
目的探讨表达不同活性的糖原合成激酶3β(GSK3β)对自噬通路的调节是否会引起α-突触核蛋白自噬水平的变化及其对细胞生长的影响。......
Abnormal protein aggregation has been linked to many neurodegenerative diseases,including Parkinson’s disease (PD).The ......
Alpha-synuclein plays an important role in Parkinsons disease (PD). The current study of alpha-synuclein mainly concentr......
目的 构建及鉴定人野生型和突变型α-突触核蛋白(SNCA和SNCAmu)基因慢病毒表达载体，并观察在体外大鼠嗜铬细胞瘤细胞中的表达。方法......
Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor sym......
【目的】构建pEGFP-N1-α-synuclein真核表达载体，为研究帕金森病奠定基础。【方法】设计特异引物，PCR扩增α-synuclein cDNA并引入F......
目的构建人A53T突变型α-突触核蛋白过表达的SHSY5Y细胞模型,观察Aβ1-42寡聚体对细胞的毒性作用和自噬功能的影响。方法利用慢病......
目的 探讨线粒体ATP敏感钾离子通道开放剂二氮嗪、线粒体膜渗透性转换孔抑制剂环孢菌素A,以及两者协同对α-突触核蛋白片段的非淀......
目的构建携带人alpha-突触核蛋白真核重组质粒,检测其在人神经母细胞瘤SK-N-SH细胞中的表达及对细胞存活率的影响。方法 PCR扩增al......
目的:通过鱼藤酮持续灌胃构建的帕金森病小鼠模型研究α-突触核蛋白寡聚体(α-Syn)的毒性作用机制。方法:48只老年雄性C57小鼠随机......
Unfolded annealing molecular dynamics conformers for wild-type and disease-associated variants of al
Aggregation of alpha-synuclein leads to the formation of Lewy bodies in the brains of patients affected by Parkinson'......
Objective: Epidemiological studies have found that lead exposure increases the risk for Park-inson’s disease and patien......
Objective: Epidemiological studies have found that lead exposure increases the risk for Park-inson’s disease and patien......
Alpha-synuclein is the major component of Lewy bodies, insoluble protein aggregates, found in patients with Parkinson’s......
Implications of alpha-synuclein nitration at tyrosine 39 in methamphetamine-induced neurotoxicity in
Methamphetamine is an amphetamine-type psychostimulant that can damage dopaminergic neurons and cause characteristic pat......
Navigating the dynamic landscape of alpha-synuclein morphology:a review of the physiologically relev
N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfun......
Alpha-synuclein 在 Parkinson 的疾病(PD ) 起一个重要作用。alpha-synuclein 的当前的学习主要在基因水平专注。然而，在蛋白质水......
