topoisomerase相关论文
DNA 的超长度和双螺旋性质使其在在复制、转录和基因表达的过程中需要不断地进行超螺旋和解旋状态之间的转换,在这一过程中,DNA 拓......
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Evodiamine-inspired Dual Histone Deacetylase 1(HDAC1)and Topoisomerase 2(Top 2)Inhibitors with Poten
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages ......
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Cyclometalated Ru(Ⅱ)complex as dual catalytic inhibitors of human Topoisomerase Ⅰ and Ⅱα induce necr
Topoisomerases(Topo)play a key role in the progression of essential cellular processes and have been highlighted as ......
Systematic structure modification of the side train of the lead compound saprothoquinone provides a series of salvicine ......
为进一步研究抗着丝粒抗体(ACA)和抗局部同分异构酶I(topoisomerase I,简称topo I)抗体与临床的联系,作者对355例病人的血清进行......
Design,Synthesis and Antitumor Activity of Fluoroquinolone C3 Heterocyclic Bis-oxadiazole Methylsulf
To discover an efficient route for the shift from an antibacterial fluoroquinolone to an antitumor one based on the mech......
拓扑异构酶(topoisomerase,topo)是参与DNA拓扑结构调整和转录、复制、修复的重要工具酶,由活性Tyr残基向DNA发动亲核攻击,导致DNA......
Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of ca......
A series of new 3-benzoheterocyclic substituted pyridopyrimidines were designed and synthesized.Structures of the compou......
Novel DNA binding agents against topoisomerases are needed for effective treatment of cancers. A series of new acridine-......
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antit
A series of novel E-ring modified evodiamine derivatives were designed and synthesized as antitumor agents. Their capaci......
A series of novel naphthalimide-derived metronidazoles as new type of antimicrobial agents were for the first time desig......
目的 从细胞分子水平对胆囊癌化疗的耐药性进行研究 ,为临床化疗药物的筛选提供理论依据并获得更有效的临床化疗效果。方法 应用......
Objective: To study the active sites of podophyllotoxin derivatives. Methods: Some podophyllotoxin derivatives were anal......
The antitumor mechanism of etoposide (VP-16) is investigated using pulse radiolysis technology. The oxidizing mechanism ......
AIM:rAAV mediated endostatin gene therapy has beenexamined as a new method for treating cancer.However,a sustained and ......
Methylation profile of the promoter CpG islands of 14 “drug-resistance”genes in hepatocellular carci
AIM:To establish the DNA methylation patterns of thepromoter CpG islands of 14“drug-resistance”genes inhepatocellular......
DNA拓扑异构酶Ⅱ(DNA topoisomeraseⅡ,TopoⅡ)是生物体内广泛存在的一类核蛋白,通过调节核酸结构动态变化,在DNA复制、修复、转......
目的 探讨 DNA拓扑异构酶 ( Topo )与胃癌的分型、分期以及预后的关系。方法 应用抗 DNA拓扑异构酶 单克隆抗体 SWT3 D1对 80......
目的 :明确非小细胞肺癌 (nonsmall cell lung cancer,NSCL C)中 Topo 表达与组织类型、细胞分化程度、TNM分期是否相关 ;是否影响......
DNA拓扑异构酶 (topoisomerase ,TOPO )是一种基本的核酶 ,催化超螺旋结构的双链 DNA中某一条链的断裂和再接反应 ,从而改变 DN......
Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its
AIM:To investigate the expression and function of classicalprotein kinase C(PKC)isoenzymes in inducing MDRphenotype in ......
尖锐湿疣为常见性病,它是由人乳头瘤病毒(HPV)感染所致,其中HPV6、11、16、18是引起尖锐湿疣的最常见亚型.其临床表现为乳头瘤样增......
II型DNA拓扑异构酶是一类ATP依赖性酶,能引导双链DNA绕过另一个双链上的缺口来催化基因组DNA拓扑结构的改变。在哺乳动物中,II型DN......
Salvicine is a novel diterpenoid quinone compound obtained by structural modi-fication of a natural product lead isolate......
Methylated Micrococcus luteus DNA （M. L. DNA） in which the DNA methylation level was 2.39% was prepared by using Hhal DNA ......
拓扑异构酶与抗癌药酶,在与DNA有关的遗传功能中显示重要作用。该酶主要包括Topo Ⅰ、ToooⅡ两种类型。以Topo Ⅰ、TopoⅡ为靶分......
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ObjectivesToelucidatetherapeuticmechanismoftopticalcamptothecin (CPT) intreatingpsoriasisandtodetecttheefectsofCPTo......
AIM: The genes were divided into seven categories according to biological function; apoptosis-related, immune response-r......
Evolutionary trace analysis of eukaryotic DNA topoisomerase I superfamily: Identification of novel a
The studies of novel inhibitors of DNA topoisomerase I (Topo I) have already be-come very promising in cancer chemothera......
Therapy-related acute myeloid leukemia (tAML) is one of the two forms of secondary acute myeloid leukemia, with one deri......
Recently, many reports showed that most of cytotoxic anticancer drugs in current usesuch as DNA topoisomerase Ⅰinhibit......
糖基化神经酰胺合成酶(glucoceramide synthase,GCS)是调控神经酰胺代谢的关键酶之一,其活性增高可能是引起肿瘤获得性多药耐药产......
在拓扑异构酶Ⅰ缺失的大肠杆菌突变株中,抑制转录和翻译可以消除高度负超螺旋.为了检测起作用的拓扑异构酶,在拓扑异构酶Ⅰ缺陷的......
As one of the immediate-early(IE)proteins of herpes simplex virus type 1(HSV-1),ICP22 is a multifunctional viral regulat......
In order to search for new potent anti-cancer agents, a series of boswellic acid derivatives were designed and synthesiz......
Inhibitory effects of reserpine and carbonyl cyanide m-chloro-phenylhydrazone on fluoroquinolone res
Mechanisms of bacterial resistance to fluoro-quinolones may be grouped into three principal categories: gene mutations o......
Thirteen homocamptothecin derivatives were synthesized and in vitro antitumor activities were evaluated by the standard ......
Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice
AIM: To establish a multidrug resistant (MDR) cell sub- line from the human hepatocarcinoma cell line (HepG2) in nude mi......
Aim:To build up a quantitative structure-activity relationship(QSAR)model of20(S)-camptothecin(CPT)analogs for the pred......
Five fluorinated podophyllotoxin derivatives were synthesized using dimethylamino- sulfurtrifluoride (DAST).
Five fluor......
固有免疫反应是机体抵御病原微生物的第一道防线。机体感染病原微生物后,有许多基因的转录和表达异常与过度炎症导致的组织损伤相......
Norfloxacin methanol solvate (1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3- quinoline carboxylic acid methanol......
肺癌是人类最常见的恶性肿瘤之一,全身化疗在肺癌的治疗中仍占有相当重要的地位。近年来,随着抗肿瘤药物作用机理的深入研究,新的......
Synthesis and Crystal Structure of 1,7,7-Trimethyl-4-(4-methoxyphenyl)-4,6,7,8-tetrahydroquinoline-2
The title compound (C19H23NO3) was synthesized by the one-pot reaction of p-me- thoxybenzaldehyde, Meldrum’s acid, dime......
