cytotoxic相关论文
目的:探讨细胞毒性T细胞淋巴瘤（cytotoxic T-cell lymphoma，CTL）临床病理学特点及预后。方法:回顾性收集2008至2020年首都医科大学附......
Objective: To elucidate the cytotoxic effect of the secondary metabolites of Barrientosiimonas humi (B. humi) on MCF-7 a......
Thibetanosides E-H (1-4),four new steroidal constituents including three rare sulfonates (2-4),were isolated from the ro......
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Objective:This study was designed to investage the mechanism of toxic effect of the cobalt nanoparticles(Co-NPs) and cob......
BackgroundDiverse physiological and pathological functions of 27-hydroxycholesterol (27-OHC)were proved.However,cytotoxi......
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Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel
Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune sys......
Phytochemical investigation of the vinegar-prepared Corydalis yanhusuo led to the isolation of one aristolactam derivati......
<i><span style=\"font-family:Verdana;\">Senna crotalarioides</span></i><span style=\"font-family:;\" \"=\"\......
Cancer is a set of diseases including abnormal growth of cells that can spread to another tissue. Verbascoside (or acteo......
CLINICAL APPLICATION OF MONOCLONAL ANTIBODY-DRUG CONJUGATE TO IMMUNOTARGETING CHEMOTHERAPY OF BLADDE
Monocional antibody-drug conjugate was applied in a clinical trial for patients with bladder cancer.Monoclonal antibody ......
Induction of cytotoxic T lymphocyte respones in vivo after immunotherapy with dendritic cells in pat
The aim of the present study was to determine the efficacy of immunotherapy with dendritic cells to elicit EBV-specific ......
Effects of cytotoxic T lymphocytes on hepatoma cell line SMMC-7721 induced by different subsets of d
BACKGROUND: Dendritic cells (DCs) loaded with complex antigen are always used to induce cytotoxic T lymphocytes (CTLs) w......
Clusterin,a protein associated with multiple functions,is expressed in a wide variety of mammalian tissues.Although clus......
AIM: To study host gene expression and numberof immune cells in liver tissues from patients with fulminant hepatitis E(F......
目的：研究乳浆大戟（Euphorbia esula）地上部分的化学成分。方法：利用反复硅胶和凝胶LH-20柱层析进行分离和纯化,通过理化性质和波谱数......
<正> A Chinese herb called Donglincao was identified as Rabdosia rubescens (Hemsl) Hara (Labiatae). It is widely distrib......
The Effect of Interleukin-6 on the Proliferation of Prostate Cancer Cells in Vitro and the Modulatio
The role of interleukin-6 (IL-6) in the growth of an androgen-independent prostate cancer cell line (PC-3m) was defined ......
Isolation,structural determination and cytotoxic activity of two new ceramides from the root of Isat
Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Thei......
A series of benzimidazole bearing 2-pyridones 5a-k were synthesized and assessed in vitro for their activity as antimicr......
Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivative
A series of novel 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytoto......
To search for more potent antitumor agent,a series of novel nitric oxide-donating colchicine(Col) derivatives(6a-f,8a an......
Synthesis of polyethylenimine grafted with copolymers of polyethylene glycol and polycaprolactone an
Copolymers mPEG-PCL were prepared and grafted onto polyethylenimine(PEI) to synthesize copolymers mPEG-PCL-g-PEI with lo......
A new diterpene and a new sesquiterpene were isolated from Pteris dispar and identified on the basis of spectral data in......
A series of furoxan-based novel nitric oxide-donating ursolic acid(UA) derivatives(7a-f) were synthesized,and their cyto......
A new lignan glycoside was isolated from the n-butanol extract of the roots and rhizomes of Sinopodophyllum emodi.On the......
应用新型单克隆抗体T_8/S_6F_1和流体细胞测定仪双色荧光程序检测了15例Graves病和8例Hashimoto甲状腺炎患者循环和甲状腺内的细胞......
Synthesis and cytotoxic activities of a series of novel N-methylbisindolylmaleimide amino acid ester
A series of novel N-methylbisindolylmaleimides and natural amino acid conjugates were synthesized and evaluated for thei......
Synthesis,spectroscopic characterization and in vitro antitumor activities of some novel mononuclear
The synthesis and spectroscopic characterization of ruthenium complexes(R-l to R-8) of the type[Ru(A)_2(B)],(where A = 1......
A series of 2,6-disubstituted-4-morpholinothieno[3,2-d]pyrimidine derivatives were synthesized and their cytotoxic activ......
The present review is aimed at providing a comprehensive summary on the botany,utility,phytochemistry,pharmacology,and c......
Synthesis and Antitumor Activity of 2-[1-(2-Formylamido-3-phenylpropionyloxy)alkyl]-1,4dihydroxy-9,1
A series of 2-[1-(2-formylamido-3-phenylpropionyloxy)alkyl]-1,4-dihydroxy-9,10-anthraquinone(2FPADHAQ) derivatives was d......
A new isocoumarin from metabolites of the endophytic fungus Alternaria tenuissima(Nees & T.Nees:Fr.)
A new isocoumarin,tenuissimasatin(1),was isolated from metabolites of the endophytic fungus Alternaria tenuissima(Nees &......
Design,synthesis,characterization,cytotoxic and structure activity relationships of novel Ru(Ⅱ) comp
Platinum containing compounds have shown antineoplastic potential, but their clinical applications have been limited by ......
Synthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as n
An efficient synthesis of novel 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine scaffold has been designed and deveopled. A......
To explore new platform for DNA intercalation and potent antitumor agent,a series of 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9......
In search of novel anticancer agents,a series of thalidomide analogs(6a-j)were designed and synthesized.Cytotoxicity of ......
Two new prenylated indole alkaloids,namely,dihydrocarneamide A(1) and iso-notoamide B(2),were isolated from the marine-d......
Synthesis and biological evaluation of nitric oxide-releasing sixalkoxyl biphenyl derivatives as ant
A series of novel nitric oxide-donating sixalkoxyl biphenyl derivatives (14a-l) were synthesized by coupling furoxan wit......
The recovery and protective effects of asiatic acid on differentiated human neuroblastoma SH-SY5Y ce
Objective:To investigate the effect of asiatic acid(AA) on the differentiated human neuroblastoma SH-SY5 Y cells cytotox......
Tagetones A(1) and B(2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Ta......
Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized.Their struct......
Mechanism for ginkgolic acid(15:1)-induced MDCK cell necrosis: Mitochondria and lysosomes damages an
Ginkgolic acids(GAs), primarily found in the leaves, nuts, and testa of ginkgo biloba, have been identified with suspect......
The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, st......
THE STUDIES OF SERUM CVB-SPECIFIC IgM ANTIBODY AND NITRIC OXIDE AMONG THE PATIENTS WITH LATENT AND C
Objective To investigate the serum coxsackie virus B(CVB) infection and nitric oxide (NO)level of the patients suffer fr......
Synthesis,Crystal Structure and Cytotoxic Activities of 1-(Prop-2-yn-1-yl)-7,8-dihydro-1H-benzo[d][1
The important synthetic precursor(Ⅲ), 1-(prop-2-yn-1-yl)-7,8-dihydro-1Hbenzo[d][1,3]thiazine-2,5(4H,6H)-dione(C_(11)H_(......
Three new pyrrolizidine alkaloids, nervosine VⅡ (1), nervosine VⅢ(2) and nervosine Ⅸ(3) were isolated from the whole......
A novel copper(Ⅱ) complex based on chiral amino-alcohol derived Schiff base ligand,[Cu_4(R-L)_4(H_2O)_2]·(CH_3COOH)_2......
