tubulin相关论文
一、背景:抑郁症是一种高复发风险的神经精神疾病。新近大量研究发现,虽给予长期持续抗抑郁药物治疗但仍有大量抑郁症患者愈后复发......
Mechanism of Action of the Benzimidazole Fungicide on Fusarium graminearum: Interfering with Polymer
Tubulins are the proposed target of clinically relevant anticancer drug,anthelmintic,and fungicide....
The combretastain A4,isolated from the bark of the South African tree Combretum Caffrum,is a potent cytotoxic agent that......
Tubulin regulates mitochondrial shape and function in rat skeletal muscle induced by the eccentric e
Objective:Microtubules are essential cytoskeletal components that play a crucial role in events such diverse as cell mot......
Background: The high-load exercises should induce the ultrastructural changes in skeletal muscle,by the ways of the depo......
目的：探讨Pax8和Tubulin在卵巢浆液性肿瘤中的表达情况及临床意义.方法：采用免疫组化SP法检测28例正常卵巢组织、38例卵巢良性浆液性......
The basic contractile unit of the mature skeletal muscle fiber, the sarcomere, represents a highly organized and elabora......
Design,Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified CA-4Analogues as Po
Tubulin,the major structural component of microtubules,has become a target for the development of anticancer agents.A se......
Synthesis,biological evaluation and molecular docking studies of novel l-(4,5-dihydro-lH-pyrazol-1-y
A series of novel compounds(6a-6v)containing l-methylindol and 31-(4,5-dihydro-lH-pyraxol-1-yl)ethanone skeleton were de......
Background:Cott on fibers are single-celled exte nsions of the seed epidermis,a model tissue for studying cytoskeleton.T......
Background:Cotton fibers are single-celled extensions of the seed epidermis, a model tissue for studying cytoskeleton. T......
Synthesis, biological evaluation and molecular docking studies of novel 1-(4,5-dihydro-1H-pyrazol-1-
A series of novel compounds(6a-6v)containing 1-methylindol and 31-(4,5-dihydro-1H-pyrazol-1-yl)ethanone skeleton wer......
Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Po
A series of 1-methyl-1H-indole–pyrazoline hybrids were designed,synthesized,and biologically evaluated as potential tub......
Synthesis and biological evaluation of novel indole derivatives containing sulfonamide scaffold as p
Microtubule-targeted drugs play a critical role in various types of cancer therapy worldwide.In our study,a series o......
目的对比人乳头瘤病毒(human papillomavirus,HPV)16E6E7基因阳性的人宫颈癌细胞(CasKi细胞株)和人宫颈鳞状上皮永生化细胞(H8细胞......
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采用丙酮粉抽提，ＤＥＡＥ－Ｓｅｐｈａｄｅｘ Ａ－５０、Ｓｅｐｈａｃｒｙｌ Ｓ－３００、ＭｏｎｏＱ柱层析，从银杏花粉中分离纯化出微管蛋白，其两个亚基的分子量分别为５４ｋＤ和５２ｋＤ纯化的微管蛋白可与鸡脑微管蛋白抗体发......
硫的衍生物潜在的威胁着胚胎的发育过程.斑马鱼被用于研究不同浓度（1×10-6～1mol/L）的硫代硫酸钠（sodiumthiosulfate,STS）对胚胎发......
目的探讨BMP和Notch信号通路介导红景天苷诱导骨髓间充质干细胞(MSCs)向神经细胞定向分化的分子机制。方法实验分为对照组、红景天......
目的 检测糖尿病小鼠脑内Tau蛋白不同位点的磷酸化状态及 β淀粉样肽表达的改变 ,进一步探讨糖尿病脑病的机理并观察APP17肽的作......
目的本研究通过回顾性分析,从针对非小细胞肺癌(NSCLC)一线化疗的铂类、吉西他滨、微管类药物中,选择各自具有代表性的耐药基因ERC......
Synergistic Effects of Activin A and Fibroblast Growth Factor 2 in the Modulation of Insulin Express
Diabetes is the most prevalent and serious metabolic disease, and the number of diabetic patients worldwide is increasin......
Synthesis and biological evaluation of 5,6,7-trimethoxy-1-benzylidene-3,4-dihydro-naphthalen-2-one a
A series of new combretastatin-A4 analogs were synthesized,in which a six-membered ring connects the linking bridge and ......
合适的内参基因是利用qRT-PCR准确分析基因相对表达量的先决条件。为了对鹿茸生长中心细胞和鹿茸干细胞间的差异表达基因进行准确......
To date,it remains poorly understood whether astrocytes can be easily reprogrammed into neurons.Mash1 and Brn2 have been......
一些曲霉是主要的食物腐败菌及人的病原体,特别是免疫系统受损的病人可能导致严重的感染。本研究评价了利用基质辅助激光解吸电离......
据在近期出版的《国际癌症杂志》(IJC)上刊登的一篇报道称,Combretastatin A-4药物前体(CA-4PD)通过直接杀伤细胞和诱导肿瘤内血......
The thermal property of the polymerization of brain tubulin was studied by a highsensitivity differential scanning calo......
A highly sensitive linear sweep voltammetric method was developed for the determination of paclitaxel and the mechanism ......
The fungicide resistance of anthracnose in Camellia oleifera nurseries was investigated in Liuyang,Changning,and other r......
目的探讨音乐治疗对慢性轻度不可预测性应激(CUMS)大鼠脑内前额叶、海马、下丘脑等脑区5-羟色胺及微管蛋白的水平及可能作用机制。......
目的探讨Cep70通过调控乙酰化α微管蛋白的稳定性，参与乳腺癌紫杉醇耐药的机制。方法⑴采用紫杉醇大剂量冲击方法处理MCF-7，历时6个......
目的 探讨β-微管蛋白Ⅲ在局部晚期宫颈癌(LACC)组织中的表达及其意义.方法 应用免疫组织化学SP法检测47例LACC组织中β-微管蛋白......
目的 研究鼻咽癌中CK、Tubulin-β及PCNA的表达,探讨其与鼻咽癌放疗后复发和转移的可能机制.方法裸鼠体内移植瘤实验观察鼻咽癌细......
微管是细胞骨架的主要成分,其结构及动力学机制对提高生物体耐受性具有重要作用。微管网络如何通过结构的动态变化调控适应环境变......
Polyglutamylase activity of tubulin tyrosine ligase-like 4 is negatively regulated by the never in m
BACKGROUND Tubulins,building blocks of microtubules,are modified substrates of diverse post-translational modifications ......
Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma
Development of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment......
Taxotere resistance in SUIT Taxotere resistance in pancreatic carcinoma cell line SUIT 2 and its sub
AIM:To Investigate the specific mechanisms of intrinsic andacquired resistance to taxotere(TXT)in pancreaticadenocarcin......
Aim:To study the role of microtubule dynamics and microtubule associated pro-tein 1B(MAP1B)in regulation of the neurite......
This paper proposes a 3-dimensional coarse grain model of microtubules and treats the tubulin monomer as a sphere of mul......
AIM To investigate the interaction of Zot withmicrotubule.METHODS Zot affinity column was applied topurify Zot-binding ......
Brain-derived neurotrophic factors increase the proliferation and differentiation of endogenous neur
BACKGROUND: It has been confirmed that brain-derived neurotrophic factor (BDNF) can promote the proliferation of neural ......
BACKGROUND:Midbrain-derived neural stem cells (mNSCs) can differentiate into functional mature dopaminergic neurons. The......
少突胶质细胞作为中枢神经系统的髓鞘形成细胞,在体外培养时形成一个精细的突起网络,细胞生长并中止于富含髓鞘相关蛋白和脂质的膜......
Two potentially specific but relevant patterns of proteomic change Response of SH-SY5Y cells to diff
Dopamine (DA) exposure at a dose of 100 μmol/L for 24 hours causes oxidative stress in SH-SY5Y cells with induction of ......
Parkinson’s disease(PD)is the second most common neurodegenerative disorder and is characterized by its progressive cou......
Glucagon-like peptide-1 (GLP-1) and its long-acting analogues have neuroprotective and neurotrophic properties and are e......
Cytoskeletal changes in transformed cells (LM-51) exhibiting obviously metastatic capabilities were investigated by util......
