targeting相关论文
＜正＞纤维素作为一种生物可再生和生物相容性的绿色材料,近年来受到越来越多的关注,目前有大量工作对其进行物理和化学改性,以期得到......
Ischemic stroke is a common and often devastating disease that primarily affects the elderly. Treatment currently consis......
Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA seque......
Evaluation of RGDS-lipid nanoparticles carrying subtilisin FS33 on thrombolytic and targeting in viv
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As drug carriers,polymersomes (Ps) have many advantages over the classical liposomes,including adequate stability,long c......
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biom......
Application of nanobiotechnology to deliver therapeutic drugs selectively to diseased sites with imp
A number of drugs only give rise to limited clinical response when causing remarkable toxicities due to wide distributio......
Galactosylated Poly(ethylene glycol) Methacrylate-s-N-3-Guanidinopropyl Methacrylamide as siRNA Carr
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The expression level of specific enzymes like matrix metalloproteases (MMPs) is often higher in tumor than in normal tis......
Most photothermal converting systems are not biodegradable,which can bring the uneasiness when they are administrated in......
Biomarkerless targeting and binding of nanoprobes on cancer cells via lactate secretion-generated ne
A great challenge in cancer diagnosis is to locally recognize the cancer cells at the molecular level with highly specif......
RUTHENIUM COMPLEXES AS POTENTIAL INHIBITOR AGAINST THE INVASION OF TUMOR CELLS TARGETING TO THE FORM
A series of ruthenium(Ⅱ)have been designed and investigated as potential inhibitor against metastasis of tumor....
Gold nanostars(AuNSs)have been extensively studied as photothermal conversion agents for cancer therapy due to their hig......
Infectious caused by intracellular pathogens,such as viral,bacterial and parasites have been a serious worldwide public ......
Stimuli-responsive nanocarriers based on mesoporous silica nanoparticles and magnetic iron nanoparti
Construction of stimuli-responsive controlled release system for targeted drug delivery to specific cells is essentially......
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Π-Π stacking stabilized polymeric micelles loaded with hydrophobic photosensitizer or chemotherapeut
Polymeric micelles (PM) have been extensively investigated for tumor-targeted delivery of hydrophobic therapeutic agents......
MRI imaging of brain glioma using dual-targeting SPIONs with three different molecular weight of Pol
Purpose:Brain glioma is the most common primary intracranial tumor with high recurrence rate and high death rate.MRI is ......
Objective Malignant tumors are diseases with extremely high mortality,which seriously endanger human health....
Targeting interleukin 21 to tumor-reactive PD-1+T cells enhances memory T cell responses and anti-PD
Objective PD-1 expression on CD8+T cells is induced by T cell activation to control immune responses.This system is hija......
N-Trimethyl Chitosan Nanoparticle–encapsulated Lactosyl-Norcantharidin for Liver Cancer Therapy with
Purpose: To develop a new liver-targeting drug delivery system (Lactosyl-norcantharidin Ntrimethylchitosan nanoparticles......
Environmentally sensitive micelles co-delivering drug and siRNA for targeting therapy of proliferati
Previous studies have shown that orthotopic non-small cell lung cancer (NSCLC) showed strong ability of invasion and met......
A class of near-infrared fluorescence (NIRF) heptamethine cyanine dyes that are taken up and accumulated specifically in......
Background Gene therapy, especially nucleic acids mediated RNA interference (RNAi), has been use in both basic research ......
A new type of cyclodextrin based,specifically modified fluorescence gold nanoclusters as carrierrs f
Multifunction drug delivery and combined multimodal therapy strategies are very promising in tumor diagnostic and theran......
Orientation of Training Scheme and Explorations on Realization Methods for Law Major Talents in Char
Under the background of emerging market-oriented operation of college education, the law education on Academic School le......
Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expres
Pygopus-2 over-expression has been reported in several malignancies,such as ovarian,breast,lung and liver cancers.Here w......
Polymer-Assisted Synthesis and Functionalization of Fe_3O_4/Au Composite Nanoparticles for Precision
Development of functionalized Fe3O4/Au composite nanoparticles(NPs)having a controllable size,narrow size distribution,a......
MRI detection of endolymphatic hydrops in Meniere’s disease in 8 minutes using MIIRMR and a 20-chann
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目的探讨放射性同位素示踪技术在生物药临床研究中的应用价值。方法对3名健康志愿者静脉滴注131I标记的国际一类新药美珀珠单抗，通......
Misalignment is one of the most common faults for the diesel engine.In order to eliminate the misalignment fault of the ......
Nanotechnology has changed the entire paradigm of drug targeting and has shown tremendous potential in the area of cance......
Regulatory role of sorting nexin 5 in protein stability and vesicular targeting of vesicular acetylc
Accurate targeting of vesicular acetylcholine transporter(VAChT)to synaptic vesicles(SVs)is indispensable for efficient ......
Elite capture,the“follow-up checks”policy,and the targeted poverty alleviation program:Evidence from
Decentralized methods for targeting poverty are widely adopted in developing countries to improve the performance of var......
Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-se
The current aggregation-induced emission luminogens(AIEgens) sometimes suffer from poor targeting selectivity due to und......
Palladium nanoplates scotch breast cancer lung metastasis by constraining epithelial-mesenchymal tra
Metastasis accounts for the majority of cancer deaths in many tumor types including breast cancer.Epithelial-mesenchymal......
Hyaluronic acid modified prussian blue nanoparticles for effectively targeted photothermal and photo
Developing a nanoscaled theranostics with simple compositions to realize multiple diagnostic,therapy and targeting i......
Here,we report a strategy to deliver drug nanoparticles into cells with nucleus-targeting ability under a spatiotemporal......
Experimental study on siRNA expressing vector-based RNA interference targeting c-Myc in human hepato
Objective: To explore the inhibition of the expression of c-Myc in human hepatocellular carcinoma via vector-based RNA i......
Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hep
AIM: To reverse the multidrug resistance (MDR) by RNA interference (RNAi)-mediated MDR1 suppression in hep-atoma cells. ......
Background Bladder cancer is the most common type of urinary system tumours. It is frequently associated with genetic mu......
Objective:Cervical cancer has become a major public health problem.The development of effective,systemic therapies for c......
Molecular characterization of sandflies and Leishmania detection in main vector of zoonotic cutaneou
Ohjective:To assess molecular characterization,distribution,seasonal activities of sandfly species and Leishmania parasi......
In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(H......
Inflammatory bowel disease(IBD)is a group of chronic disorders of the gastrointestinal tract comprising Crohn’s disease......
Objective:To identify the Leishmania species in infected sand flies by Real-time PCR coupled with HRM analysis.Methods:R......
Hepatitis C virus(HCV)infection is a global health problem,with an estimated 170 million people being chronically infect......
The current therapeutic regimen to combat chronic hepatitis C is not optimal due to substantial side effects and the fai......
The intestinal microbiome is emerging as a crucial mediator between external insults and systemic infections. New resear......
