RETINOID相关论文
Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell prolifera......
Since disability in multiple sclerosis(MS) is a product of neurodegeneration and deficient remyelination, the ability to......
目的 :观察不同保存条件下血清中TPS活性变化 ,为血清库建立提供依据。方法 :取肝癌、肺癌患者血清 5例 ,分别于 2 5℃、4℃、- 2 ......
目的:探讨维甲酸(RA)诱导鼻咽癌端粒酶及hTR表达下降和凋亡改变。方法:10-5mol/L维甲酸处理HNE1细胞后,采用TRAP PCR ELISA、逆转......
AIM:To investigate and determine the mechanism and signalpathway of tetradecanoylphorbol-1,3-acetate(TPA)indegradation ......
一、类视黄醇化合物及其生理活性天然类视黄醇 (retinoid)的末端功能基有 3型 :醇型、醛型和碳酸型 ,分别称做视黄醇(retinol)、视......
The effect pathway of retinoic acid through regulation of retinoic acid receptor α in gastric cancer
AIM To evaluate the role of RARα gone in mediating thegrowth inhibitory effect of all-trans retinoic acid(ATRA)on gast......
In order to identify the genes associated with glioblastoma differentiation, some ESTs, expressed differentially in the......
Effects of retinoic acid on proliferation,phenotype and expression of cyclin-dependent kinase inhibi
AIM To study the molecular mechanisms ofretinoic acid(RA)on proliferation andexpression of cyclin-dependent kinase inhi......
Objective The present study was designed to examine whether the renin-angiotensin system would be implicated in the deve......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
近年来,视黄素(retinoid)对癌细胞生长的抑制作用,以及临床上治疗癌症的效果引起人们的极大关注。视黄素的作用主要由其受体:视黄......
干扰素/维甲酸联合应用诱导细胞凋亡相关的基因19(gene associated with retinoid-interferon-induced mortality-19,GRIM-19)是一......
目的:探讨全反式维甲酸(all-tran retinoid acid,ATRA)对人食管鳞癌EC1细胞增殖、细胞周期和细胞凋亡的影响,并初步探讨其可能的机......
2008358 The effect of activating retinoid X receptor inhibiting hydrogen peroxide-induced apoptosis in cultured rat neo......
引言维生素 A 类化合物(以下简称 VA 类化合物)的化学和生物学研究还刚刚开始。近十年是 VA 类化合物化学和生物学研究的复兴时期......
Hormones and their receptors regulate cell growth,differentiation and apoptosis and also play important rolesin immune ......
利甘地制药公司向ＦＤＡ提出ｒｅｔｉｎｏｉｄ的新药审查申请利甘地（Ｌｉｇａｎｄ）制药公司已就其产品ｒｅｔｉｎｏｉｄ（ＬＧＤ－１０６９）向美国ＦＤＡ提出ＩＮＤ申请，拟将其用于皮肤癌及其它皮肤病的治疗。计划先试用于......
Effects of transforming growth interacting factor on biological behaviors of gastric carcinoma cells
AIM: Transforming growth interacting factor (TGIF) is an inhibitor of both transforming growth factor β(TGF-β) and ret......
Mechanism of retinoid receptors in inhibiting proliferation and inducing apoptosis of human melanoma
Malignant melanoma is a common cancer of skin. Its incidence is growing rapidly in recent years,~1 however, there is no ......
我们用离子交换层析和亲和层析的方法提纯了视网膜S抗原和光感受器间维生素A类结合蛋白(interphotoreceptor retinoid—bindingpro......
Optimal expression of Hh_1-like response requires IL-4 at early stage of experimental autoimmune uve
IL-4 is a Th_2-type cytokine which plays a major role in determining the Th_o-type cell differentiation towards Th_2-ty......
Objective:To investigate the effects of synthetic retinoid CD437 and acitretin on cell proliferation,apoptosis,cycle arr......
All-trans retinoid acid (ATRA) is one of the most potent and most thoroughly studied differentiation inducers that induc......
Supportive therapies for prevention of hepatocellular carcinoma recurrence and preservation of liver
Hepatocellular carcinoma(HCC) is one of the deadliest cancers in the world and is associated with a high risk of recurre......
Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical ag
Obesity and its related metabolic disorders are serious health problems worldwide,and lead to various healthrelated comp......
Objective: To investigate the effects of Ro13-7410on telomerase activity and cell cycle distribution.Methods: Telomerase......
Background The potential application of retinoic acid receptor activators,such as all trans-retinoic acid (ATRA),for tre......
Background The potential application of retinoic acid receptor activators,such as all trans-retinoic acid (ATRA),for tre......
在考察了不同的反应条件后,建立了以二环己基碳酰亚胺(DCC)为脱水剂、合成具有药物活性的异维A酸酯和异维A酰胺的合成方法.在温和......
目的探讨依曲替酸治疗寻常型银屑病（psoriatic vulgaris,PV）的作用机制。方法观察依曲替酸对30例PV患者的临床疗效,并用原位杂交技术......
目的对法洛四联症（TOF）患儿类视黄酸受体d（RXRA）基因启动子区序列进行分析，探讨RXRA基因变异与TOF的关联性。方法采取病例对照研究方法，......
用体内外实验模型，研究了新维Ａ类化合物４乙酰胺苯基维Ａ酸酯（４ＡＰＲ）对肿瘤侵袭、转移的抑制作用。４ＡＰＲ４３．３ｍｇ·ｋｇ－１ｐｏ即能减少小鼠Ｌｅｗｉｓ肺癌的自发性肺转移......
目的探讨复方倍他米松穴位注射联合口服阿维A及抗结核药物治疗皮肤结核的疗效。方法运用复方倍他米松穴位注射联合口服阿维A及抗结......
目的研究正常人角质形成细胞维甲酸受体（RAR）γmRNA在依曲替酸处理前后的改变。方法用0.1μmol/L和1.0μmol/L依曲替酸处理正常人角......
报道表皮松解性角化过度鱼鳞病一家系。家系中无近亲结婚史，2代8人中有5人患病。先证者男，18岁，其母亲46岁，均是出生时即患病，先证者母......
为深入探讨第三代维甲类化合物Ｒｏ１３－７４１０诱导白血病细胞凋亡和分化的机制。本文采用ＰＣＲ－ＥＬＩＳＡ和ＰＣＲ－ＰＡＧＥ两种方法观察了ｏ１３－７４１０对ＨＬ－６０细胞端粒酶活性的影响。实验结果显示......
维甲酸类药物目前在银屑病治疗中广泛应用，疗效较为满意但机制未明。本文综述了维甲酸类化合物及其受体在正常表皮分化中的作用，阐述......
目的：大鼠自身免疫性葡萄膜视网膜炎（experimental autoimmune uveoretinitis，EAU）大鼠模型眼部研究细胞因子信号抑制因子（suppressor o......
目的合成两种杂环类维A酸以用于新药筛选。方法分别以2，5-二甲基-2，5-己二醇为原料通过五步反应进行合成。结果得到了两种杂环类维A......
目的:筛选维甲酸自乳化制剂最佳处方条件。方法:以维甲酸在不同种类及比例的油相、表面活性剂中的溶解度为指标,通过溶解度试验及......
生理条件下盐皮质激素（醛固酮）主要通过盐皮质激素受体（mineralocortieoid receptor,MR）发挥作用。MR属于类固醇，甲状腺，维生素A配体依赖......
采用两种方法合成了2类新的异维A酸糖基衍生物（5a～5d,6a,10a～10c,11a）,并进行了结构表征与确认.采用MTT法测试了它们对肺癌细胞（A549）等......
The constitutive androstane receptor (CAR) is a transcription factor that belongs to the nuclear receptor superfamily. C......
Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retino
All-trans retinoic acid (ATRA) triggers a wide range of effects on vertebrate development by regulating cell proliferati......
Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer chemotherapeutic agents. With......
Ligand制药公司的选择性retinoid X受体调节剂Targretin(bexarotene)(Ⅰ)，在治疗晚期非小细胞肺癌的两项关键性一线研究中未达到主......
