TAXOL相关论文
乳腺癌是全球女性最高发的癌症,也是全球癌症相关死亡的主要原因之一。临床治疗乳腺癌的主要策略包括手术联合放化疗,多数患者在治......
在可回收和重复使用的手性催化剂(QN)2 PHAL-PEG-OMe-OOsO3K存在下,以肉桂酸甲酯为原料通过Sharpless不对称双羟化反应的关键步骤......
Capilliposide from Lysimachia capillipes restores taxol sensitivity in human ovarian cancer cells wi
目的 In this study we aimed to investigate whether LC capilliposide could overcome theresistance of multidrug resistant ......
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Increase of reactive oxygen species-mediated apoptosis by celastrol in taxol-sensitive and-resistant
Objective: Taxol resistance is a major challenge in non-small cell lung cancer(NSCLC)treatment.In this study,the anti-ca......
目的：研究紫杉醇(Taxol)对内毒素脂多糖(LPS)诱导的脓毒血症小鼠肾保护作用的影响。方法：40只小鼠随机分为4组：假手术(Sham)组、Tax01......
Taxol, an important and expensive anticancer drug, was found in extremely low amount in Taxus brevifolia bark.Recently, ......
Recently, we found that high concentration of taxol (70 μM) induced cell death with cytoplasm vacuolization, the typica......
蝉翼藤的化学成分和药理活性的研究多有报道,已从中分离得到30几种(?)酮类化合物,活性研究表明该类化合物具有抗炎镇痛、抗肿瘤等......
泰素(Taxol)已成为治疗卵巢癌最有效的化疗药物之一,其过敏反应率高达16%。关于过敏反应的病人应用泰素再次化疗虽已有报道,但所......
Objective: To evaluate the safety and pharmacokinetics of the intropritoneal(IP) drinistra tion of the antineoplastic ag......
Short Hairpin RNA-mediated MDR1 Gene Silencing Increases Apoptosis of Human Ovarian Cancer Cell Line
Objective: Recurrent ovarian cancer is often resistant to drugs such as paclitaxel. Short hairpin RNA (shRNA) targeting ......
Studies on Tripolycyanamide Formaldehyde Resin-Pd Complex and Its Use in the Synthesis of the Branch
A novel method was developed to prepare the branch of paclitaxel using 2,4-dichlorophenylaldehyde as the starting materi......
Taxol inhibits stretch-induced electrophysiological alterations in isolated rat hearts with acute my
Mechanosensitive channels have been determined to work as transducers of mechanoelectric feedback in the heart, which is......
In vitro study of the influence of GST-π gene transfer on drug-resistance of human cord blood CD34~+
Objective:To investigate the influence of GST-π gene transfer on drug-resistance of human cord blood CD34 + cells.Meth......
最近我们对美国、加拿大和印度的天然药物研究与开发进行了考察,有以下建议: 1 紫杉醇(Taxol):美国农业部1961年对太平洋紫杉进行......
[Object] To transform endophytic fungus XT5 of T.brevifolia by taxadiene synthase gene.[Method] The taxadiene synthase g......
AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was a......
为进一步研究紫杉二烯合成酶的作用机理和紫杉醇生物合成代谢调控机制,采用RT-PCR技术从东北红豆杉(Taxus cuspidata)树叶中获得了......
MULTICELLULAR-MEDIATED RESISTANCE TO CISPLATIN AND TAXOL IN HUMAN OVARIAN CANCER SK-OV-3IP1 MULTICEL
Objective: To investigate the chemosensitivity ofovarian cancer SK-OV-3ip1 multicellular aggregates (MCA) to cisplatin a......
Compound 1 as a key intermediate of 1, 7, 9-trideoxytaxol was synthesized in ten steps from a biosynthetically available......
在丽江地区,以同基质露地栽培的方式对一批同源、同龄的须弥红豆杉幼苗开展试验,通过对其生长特征及紫杉醇含量的年变化进行研究分......
用浊度法和差示扫描量热法研究了四种小分子抗癌物质犤紫杉醇、卡铂、猪芽藻提取物(ZYZ)和番荔枝素提取物(F43)犦对微管蛋白体外聚......
目的 :评价新辅助化疗对喉癌、喉咽癌的近期疗效及毒副反应 ,并探索其在喉癌、喉咽癌综合治疗中的作用。方法 :采用DFB(DDP +5 -FU......
过表达紫杉醇合成关键酶基因是提高红豆杉细胞紫杉醇产量的有效方法.本文通过构建C-l3苯丙素侧链CoA-乙酰转移酶(C-13 phenylpropa......
Comparative Study on Three Chemotherapeutic Regimens for the Treatment of Advanced Epithelial Ovaria
To investigate the best first-line chemotherapy regimen for the treatment of advanced epithelial ovarian cancer (AEOC), ......
目的：观察周低剂量紫杉醇联合钴60放疗治疗中晚期食管癌患者的疗效及毒副反应。方法：将60例中晚期食管癌患者随机分为两组，放化组（钴60......
来自第八届欧洲癌症大会临床肿瘤学的消息，两个欧洲试验的初步结果表明泰素（Taxol，紫杉醇）作为一线药物治疗转移性乳腺癌有效，且患者有......
头颈部癌(包括鼻咽癌) PF方案 DDP 40mg/d vd.d1～d3 或DDP 80～100mg/m~2 vd.d1 5-FU 500～600mg/m~2 vd.d1～d5 每3～4周重复 BPF方案......
Aim:To study the role of microtubule dynamics and microtubule associated pro-tein 1B(MAP1B)in regulation of the neurite......
To investigate the relationship between p38 mitogen-activated protein kinase (p38MAPK) and cell apoptosis during the pac......
用正常人外周血淋巴细胞为实验材料，探讨１０ｕＭｔａｘｏｌ对淋巴细胞微核化、动粒蛋白含量及核仁结构的影响。结果表明，ｔａｘｏｌ可诱导淋巴细胞微核化，ｔａｘｏｌ诱导１８ｈ，微核......
本文报道应用反相高效液相色谱法测定红豆杉提取物中紫杉醇的含量,以倍他米松作内标,在填充以10μm LiChrosorb RP-18固定相的250......
生长在美国西北部和加拿大西南部的短叶红豆杉(Taxus brevifolia),是一种矮小且生长缓慢的植物。从它的树皮中提取分离出来的一种......
紫杉醇（taxol）是从红豆杉科植物中分离出的一种二萜类化合物，是近年来发现的最有效的抗癌药物之一。为了充分利用植物资源，云南大理医......
紫杉醇(Taxol)是从红豆杉科植物中分离出的一种抗癌新药.其提取分离工艺,国内外报道甚多,但大多都比较繁杂,不利于大规模工业化生......
目的 为了进一步研究红豆杉中的紫杉烷二萜类化合物 ,对生长在我国的云南红豆杉 Taxus yunnanensis进行深入的化学研究。方法 云......
目的:探讨人肺腺癌细胞株A549及其紫杉醇耐药细胞株A549/taxol之间葡萄糖代谢的差异,以及二氯乙酸盐(dichloroacetate,DCA)对这2种......
Biological Fingerprinting Analysis of Interaction Between Taxoids in Taxus and Microtubule Protein b
Some natural products,such as traditional Chinese medicines(TCMs),contain compounds with anticancer activity and have at......
紫杉醇(Paclitaxel,Taxol;布迈·施贵宝)已被食品和药品管理局批准用于治疗那些对其他化学疗法已失去反应或仍在继续发展的卵巢癌......
美国FDA肿瘤药物咨询委员会同意紫杉醇(paclitaxel,Taxol)作为晚期卵巢癌的新二线治疗药。紫杉醇是BMS公司推荐待批的抗癌药。美......
在美国,关于从太平洋沿岸的浆果紫杉提取抗癌药紫杉醇(taxol)的问题已引起争论,对话者反对大规模破坏紫杉树。紫杉醇正处于由国立......
美国食品和药品署(FDA)已批准将紫杉醇(taxol)作为治疗卵巢癌患者的抗癌药。这种药品对于用标准的化疗法或服用以铂为基础的抗癌......
