paclitaxel相关论文
＜正＞Tumor-oriented nanocarrier drug delivery approaches with pH-sensitivity have been drawing considerable attentions over......
细胞凋亡,又称程序性细胞死亡,在维持多细胞生物发育和自稳平衡中发挥着重要作用。细胞凋亡的过盛和缺失皆可导致大量疾病的发生。......
A significant proportion of non-small cell lung cancer(NSCLC)patients experience accumu-lating chemotherapy-related adve......
Codelivery of drugs by drug carriers is a promising strategy against several diseases such as infections and cancer.Howe......
Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the int
The mechanical force between cells and the extracellular microenvironment is crucial to many physiological processes suc......
Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve
Wallerian degeneration, the progressive disintegration of distal axons and myelin that occurs after peripheral nerve inj......
Lung cancer is one of the leading causes of cancer-related death worldwide.Various therapeutic failed in the effective t......
Pure redox-sensitive paclitaxel-maleimide prodrug nanoparticles:Endogenous albumin-induced size swit
A commercial albumin-bound paclitaxel nano-formulation has been considered a gold stan-dard against breast cancer.Howeve......
Preparation of Magnetic Fluorescent Dual-drug Nanocomposites for Codelivery of Kaempferol and Paclit
Magnetic fluorescent dual-drug nanocomposites (MFDDs) were developed with the aim of simultaneouly delivering two differ......
Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Spec
Voltage-gated sodium channels (Navs) play an important role in human pain sensation.However,the expression and role of N......
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A simple Paclitaxel (PTX) prodrug based on TPGS and disulfide bond (TPGS-S-S-PTX) was synthesized by a two step esterifi......
Gemcitabine (GEM) is the most potent anti-cancer drug for the treatment of pancreatic cancer.However,it undergoes rapid ......
In vitro and in vivo evaluation of novel folate-modified lipid-polymer hybrid nanoparticles for targ
Lipid-polymer hybrid nanoparticles (LPNPs) are polymeric nanoparticles enveloped by lipid layers that combine the highly......
Truncated bFGF Peptide-medicated Active Targeting System Simultaneously Loaded with PEDF and Paclita
The ligand-mediated active targeting system is one of ideal gene delivery systems.Fibroblast growth factor receptors(FGF......
Biological evaluation of redox-sensitive hyaluronic acid micelle as a new nano-carrier for intraveno
An amphiphilic hyaluronic acid derivate,redox-sensitive hyaluronic acid-deoxycholic acid(HA-ss-DOCA)conjugate,was succes......
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Preparation and Characterization of Paclitaxel Loaded PLLA-PEG-PLLA Nanoparticles for Controlled Rel
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Biodegradable nanoparticles based on poly(D,L-lactide-co-glycolide) (PLGA,a FDA-approved polymer) have attracted an enor......
Paclitaxel(PTX)is one of the most commonly used antineoplastic agents.However,its clinical application confronts with se......
Polymeric micelles are under investigation as delivery vehicles for various anticancer drugs [1,2].However,these systems......
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Preparation and Characterization of a Smart Binary-Drug Delivery System Based on Poly(ε-caprolactone
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Reduction-sensitive nanogels based on HA and iodixanol for both tumor-targeted CT imaging and therap
In recent years,nanosized CT contrast agents have attracted great interest as they have several advantages over small mo......
Paclitaxel-Loaded Nanoparticles Decorated with Anti-CD133 Antibody for Targeting Liver Cancer Stem C
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A comparison of paclitaxel and carboplatin with fluorouracil in concurrent chemoradiotherapy in adva
Objective Oesophageal cancer is highly malignant with a propensity for high rates of local recurrence and metastasis.Alt......
The MRVI1-AS1/ATF3 signaling loop sensitizes nasopharyngeal cancer cells to paclitaxel by regulating
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POF(Paclitaxel plus FOLFOX)Versus IP PAC(Intraperitoneal Paclitaxel plus FOLFOX)Versus FOLFOX as a F
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TACC3 mediate the cisplatin and paclitaxel resistance through RHOA-MDR1 axis in bladder cancer cells
Objective Platinum drugs and paclitaxel are widely used in the treatment of advanced bladder cancer.However,the efficacy......
Overcoming paclitaxel resistance via PI3K pathway mediated stathmin1 regulation in gastric cancer ce
Objective: Recent advances in understanding of cancer biology reveal that oncogenic signaling pathway endow chemoresista......
Targeting PI3K/Akt or MAPK pathways reverses paclitaxel resistance in gastric cancer in vitro and in
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A novel functional Sericin-bound paclitaxelnanomicelle for the targeted chemotherapy in gastric canc
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Mitogen-activated protein kinase kinase 6-fusion protein (MAP2K6-FP) potentiates the anti-tumor effe
Objective: To investigate the antitumor effects of a mitogen-activated protein kinase (MAPK) kinase fusion protein,TAT-O......
Objective :To study Carboxymethyl Chitosan-Rhein conjugate(CR conjugate)effects intestinal absorption of Paclitaxel(PTX)......
Clinical significance of neoadjuvant intraperitoneal and systemic chemotherapy for the gastric cance
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Paclitaxel plus S-1 in the first-line treatment of advanced metastatic gastric cancer-efficacy and t
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Gastric cancer(GC)is the second-leading cause of cancer-related deaths worldwide,with overall 5-year survival less than ......
Presently,the majority of effective chemotherapy agents are administrated by in jection,resulting in reduced patient com......
Purpose: To prepare and characterize the targeted paclitaxel nanoparticles with biodegradable materials of lactic acid-g......
A toxic organic solvent-free technology for the preparation of PEGylated paclitaxel nanosuspension b
Clinically, paclitaxel (PTX) is one of most commonly prescribed therapies against a wide range of solid neoplasms.Despit......
Redox-sensitive hyaluronic acid-paclitaxel conjugate micelles with high physical drug loading for ef
The design of targeted polymer-drug conjugate capable of controlled drug release remains a benchmark for drug delivery s......
Synthesis, in vitro and in vivo evaluation of dual-functional tLyP-1 conjugated hyaluronic acid-pacl
Paclitaxel (PTX) is an antitumor drug which has been widely adopted in clinical treatment of cancer for years.However, i......
Low-density lipoprotein-coupled N-succinyl chitosan lipoic acid micelles co-delivering siRNA and Pac
Objective: To increase targeting effect and reverse the multiple drug resistance(MDR) on cancer cells by building and in......
Paclitaxel and Cryptotanshinone Loaded Temporal-controlled Nanoparticles for Combinatorial Cancer Th
Combination therapy has emerged as a promising strategy for treating multidrug resistant (MDR) cancer.In the previous st......
Novel 4-Arm-PEG-TPGS Amphiphilic Copolymer Micelles Loading Paclitaxel: Preparation, Characterizatio
Over the past few decades, the exploitation of branched PEG modified biocompatible and biodegradable polymers has receiv......
Nanocarriers delivering prodrugs are important strategies to improve the in vivo effectiveness and efficiency.For therap......
The pH-responsive micelles for the delivery anticancer agents have been found great potential in the past decade.Usually......
A novel lanreotide-modified micelle system targets paclitaxel to the tumors with overexpression of s
Many tumor cells specifically overexpress somatostatin receptors, in particular, subtype 2 (SSTR2). Lanreotide, a somato......
Neuroprotection of paclitaxel against cerebral ischemia/reperfusion induced brain injury through JNK
In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and the possible......
