PARP相关论文
恶性肿瘤是一种涉及多个基因,发病机理高度复杂的疾病,目前临床使用的单靶点药物不能完全杀灭肿瘤细胞而且容易产生耐药性。组蛋白......
甲基汞环境污染已成为全球性问题,日益引起人们的密切关注。长期接触低剂量甲基汞所致脑发育损伤机制一直是各国学者研究的热点。......
The tumor suppressor p53 plays an important role in the inhibition of cancer progression,particularly in response to che......
核蛋白聚（ADP-核糖）聚合酶1（PARP1）抑制剂已被证明可有效地增强化学治疗和放疗效果。然而,目前大多数PARP1抑制剂的主要问题是它们缺乏......
目的 总结PARP 抑制剂治疗乳腺癌的作用机制以及目前的临床应用及试验。方法 通过数据库查找相关文献进行分析总结。结果 PARP 抑......
Besides the KU-dependent classical non-homologous end-joining (C-NHEJ) pathway,an alternative NHEJ pathway first identif......
Effect of S003 on sulfur mustard-induced cutaneous Injuries in the mouse ear vesicant model and huma
Aim: Sulfur mustard (SM) can cause DNA damage and the activation of poly(ADPribose)polymerase (PARP).PARP inhibitor has ......
Poly(ADP-ribose)polymerase (PARP), calpain and nuclear factor-κB (NF-κB) are reported to participate in inflammatory r......
Development of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer
PARP-1 is closely related to the repair of DNA damages caused by Topo inhibitors.The combinations of PARP-1 inhibitor an......
Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decais
AIM:To investigate the anti-tumor activity of ursolic acid(UA)and its derivatives isolated from Aralia decaisneanaon he......
研究L-茶氨酸对肝细胞损伤的保护作用及其机制。利用H2O2诱导的L02肝细胞损伤模型,分别用MTT法检测细胞存活率、测定LDH、流式细胞......
目的 探讨NDGA诱导胃癌细胞凋亡的分子机制。方法 分光光度法检测caspase 3的细胞活性 ,同时用Westernblot分析caspase 3及其底......
研究黄连素对恶性胶质瘤C6细胞增殖、凋亡的影响.用MTT法分别检测不同浓度的黄连素对恶性胶质瘤C6细胞体外抑制率.通过不同时间、......
各型糖尿病均以慢性高血糖、进展性血管病变为特征。糖尿病微血管病变是糖尿病视网膜病变、肾病及各种周围神经病变的主要原因。与......
Effects of poly (ADP-ribose) polymerase inhibitor on early peripheral neuropathy in streptozotocin-d
Objective: To explore the effects and mechanisms of poly(ADP-ribose) polymerase(PARP) inhibitor 3-aminobenzamide on nerv......
目的研究天然产物白杨素(chrysin)对损伤DNA的抗肿瘤药物顺铂和喜树碱诱导肝肿瘤细胞(Hep G2)死亡的作用及机制。方法白杨素以不同......
Role of poly(ADP-ribose) polymerase 1 in DNA methylation changes induced by hydroquinone in human br
Objective To investigate the DNA methylation changes induced by hydroquinone(HQ)in human bronchial epithelial cells and ......
Mitochondrial physiology and biogenesis play a crucial role in the initiation and progression of cardiovascular disease ......
目的探讨多聚ADP核糖聚合酶(PARP)抑制剂3-氨基苯甲酰(3-AB)对实验性糖尿病(DM)大鼠血脑屏障(BBB)的影响。方法实验动物分为正常对......
目的探讨多ADP-核糖聚合酶[poly(ADP-ribose)polymerase,PARP]单核苷酸多态性位点Val762Ala基因多态性与急性冠状动脉综合征(acute......
Design, synthesis and biological evaluation of novel phthalazinone acridine derivatives as dual PARP
In this study, we designed and synthesized a series of phthalazinone acridine derivatives as dual PARP and Topo inhibito......
PARP(多聚腺苷二磷酸聚合酶)是存在于多数真核细胞中的一个多功能蛋白质翻译后修饰酶.PARP参与DNA 修复和转录调控，是肿瘤发展......
Immune-mediated activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP) is a con-sistent ifnding in a......
目的研究二甲双胍联合胰岛素对妊娠期糖尿病患者丝氨酸蛋白酶抑制剂、多聚腺苷二磷酸核糖聚合酶(PARP)水平的影响。方法选取该院20......
目的 研究二甲双胍联合胰岛素对妊娠期糖尿病(GDM)患者血清脂蛋白相关磷脂酶A2 (LpLA2)、多聚ADP核糖聚合酶(PARP)水平的影响,有效......
Objective: To investigate the relationship of poly(ADP-ribose)glycohydrolase(PARG) with poly (ADP-ribose) polymerase(PAR......
[背景]现代医学研究证明,细胞凋亡积极参与了烟雾吸入引起的急性肺损伤(ALI)过程,而不是细胞坏死。凋亡的肺细胞主要包括血管内皮......
目的:子宫内膜癌是目前女性生殖系统中常见的恶性肿瘤之一,严重危及着女性的生命安全。PI3K信号通路在80%的子宫内膜癌中处于高度......
[目的]观察Calpastatin Peptide、Calpain Inhibitor IV和Calpeptin三种钙蛋白酶抑制剂对肿瘤微环境下C2C12小鼠成肌细胞内AP-1、P......
选取过表达利钠肽受体A的细胞系HEK293 GCAC3、人肾癌细胞系ACHN、非小细胞肺癌细胞系Calu-1、A549、H1792、H1299、H157以及H460......
Ithasbeenwellknownthatarsenicisapoisonandcarcinogenformanycenturies,earlyintheQinandHanDynasties(B.C.221A.D.220),amedica......
目的:阐明病理性周期性张应力诱导人牙周膜细胞凋亡的分子机制。方法:人牙周膜细胞取自健康前磨牙,经过3?5代传代,细胞受到20%牵张......
目的观察大鼠创伤性脑损伤后损伤区周围皮质不同时点聚二磷酸腺苷核糖多聚酶(PARP)阳性细胞的表达变化。方法采用大鼠自由落体脑损......
PARP的分子生物学特征,PARP的活性调节,以及PARP与缺血性神经元损伤后DNA的修复及细胞凋亡有关,探讨了PARP抑制剂,如:尼克酰胺,对......
目的 探讨半胱氨酸蛋白酶-3(caspase-3)抑制剂z-DEVD-fmk对大脑皮层缺血再灌流区神经元凋亡的影响.方法制备大脑中动脉栓塞-再灌流......
目的:研究炎性肠病大鼠模型的迷走神经背侧运动核(DMNV)蛋白酶激活受体(PAR-1,PAR-2)存在的情况,并阐明该受体激活的机制。方法:制......
Poly(ADP-ribose)polymerase 1(PARP-1)是Poly(ADP-ribose)聚合物(PAR)合成的催化酶,在脑缺血损伤早期即出现过表达,通过加剧细胞......
目的探讨地塞米松诱导的危重病性肌病的细胞死亡方式。方法将SD大鼠分为健康对照组和实验组;实验组又分为7、9、11 d 3个时相点(n=......
目的探讨脂肪源性干细胞(ADSC)移植对大鼠脑缺血再灌注损伤区炎症递质多聚腺苷酸二磷酸核糖聚合酶(PARP)和核因子-κB(NF-κB)表达......
Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotect......
目的:探讨MAPK/ERK信号转导途径对鹦鹉热衣原体(Chlamydophila psittaci,Cps)感染细胞活性的影响。方法:利用化学抑制剂U0126阻断M......
目的:研究咖啡因对肝星形细胞活化状态和分泌功能的影响及其潜在机制。方法:选取人肝星形细胞LX-2进行体外实验。经浓度为0、5、10......
P53-mediated cell cycle arrest and apoptosis through a caspase-3-independent,but caspase-9-dependent
Aim:To study the caspase-3-independent mechanisms in oridonin-induced MCF-7human breast cancer cell apoptosis in vitro.......
Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmaco
AIM:TO investigate in vitro and in vivo therapeutic effects of histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 ......
