【摘 要】
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The tumor suppressor p53 plays an important role in the inhibition of cancer progression,particularly in response to chemotherapy or target-specific therapy.Inactivation or mutation of p53 often becomes a cancer\'s tactic for drug resis-tance.One of the
【机 构】
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Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences,Fudan University,Shang
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The tumor suppressor p53 plays an important role in the inhibition of cancer progression,particularly in response to chemotherapy or target-specific therapy.Inactivation or mutation of p53 often becomes a cancer\'s tactic for drug resis-tance.One of the clinically applied ther-apeutic strategies is to inhibit poly(ADP-ribose) polymerase (PARP) activity,as PARP inhibitors are widely used for sub-sets of tumors with homologous recom-bination deficiency due to mutation of BRCA1/2 or other DNA repair-associated genes.It has been shown that p53 defi-ciency or mutation enhances the cytotox-icity of PARP inhibition in various tumors(Williamson et al.,2012).A possible mechanism underlying this is that loss of p53 impairs DNA repair path-ways,creating additional tumor vulnera-bility to PARP inhibition,as wild-type(wt) p53 transcriptionally induces the expression of genes involved in DNA repair (Vousden and Prives,2009).
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