calpain相关论文
目的:针对心肌缺血再灌注损伤（I/R）的机制研究和治疗探索一直是热点,近年来越来越多研究发现自噬在I/R机制中发挥重要作用。Calpain......
山西黑猪作为一种地方性杂种猪,因其具有适应性强、遗传性能稳定、产仔能力强、肉质鲜美等特点已得到业内人士的广泛认可,具有广阔......
世界卫生组织2016年的报告指出全世界有4.22亿人患有糖尿病,且主要分布于发展中国家。近三十年,中国的糖尿病患病率增加了17%。如......
Calpain inhibition improves erectile function in diabetic mice via upregulating endothelial nitric o
Calpain activation contributes to hyperglycemia-induced endothelial dysfunction and apoptosis.This study was designed to......
Therapeutic efficacy of E-64-d, a selective calpain inhibitor, in experimental acute spinal cord inj
This study aims to investigate the therapeutic e ect of calpain inhibitor E-64-d on SCI and to nd a new approach to trea......
Therapeutic efficacy of E-64-d,a selective calpain inhibitor,in experimental acute spinal cord injur
This study aims to investigate the therapeutic effect of calpain inhibitor E-64-d on SCI,and to find a new approach to t......
Objective Doxorubicin(DOX)is a chemotherapy medication used to treat various cancers.However,cardiotoxic side effects li......
The efficiency of neurotransmission is determined by the level of neurotransmitter receptors at the postsynaptic densiti......
Objective: Diabetic erectile dysfunction is an intractable disease which results from both vascular and nervous dysfunct......
慢性粒细胞白血病(CML)是正常造血干细胞获得性形成BCR-ABL融合基因而诱发的克隆性血液肿瘤.抑制BCR-ABL酪氨酸激酶的小分子化合物......
目的：探讨Calpain抑制剂MDL28170对BALB/c小鼠创伤性脑损伤(TBI)后引起的神经血管单元损伤的保护作用。方法：将BALB/c雄性小鼠分为假......
Neurotoxins are harmful to brain functions,especially interrupting memory processing.Hippocampal synaptic plasticity is ......
Involvement of ERK2 and Calpain 1 signaling pathways and their cross-talk in pathophysiology of spin
Calpain (μ-and m-) and ERK1/2 activation are strongly implicated in the pathophysiology of traumatic spinal cord injury......
Activation of CDK5 by noncanonical Wnt/Ca2+ signaling during neurogenesis and neuronal differentiati
Objective Canonical Wnt/β-catenin signals play important roles during neuronal differentiation and neurogenesis, but le......
目的：观察一次低氧运动对骨骼肌Titin和Nebulin蛋白的影响及其影响机理,并观察运动后不同恢复环境下骨骼肌Titin和Nebulin蛋白恢复......
目的：探讨多溴联苯醚-153(BDE-153)神经毒性与calpain/p35-p25/Cdk5信号通路的关系,为多溴联苯醚神经毒性机制的研究提供科学依据.......
目的 Neuregulin-1β/ErbB4 信号通路在脑缺血过程中发挥重要作用,但其具体机制尚不明确,本研究详细探讨Neuregulin-1β/ErbB4 信......
DP2 Deficiency Improves Cardiac Function after Acute MI by Suppressing Cardiomyocytes Apoptosis in M
Rationale:Cardiomyocytes apoptosis contributes significantly to cardiac remolding after acute myocardial infarction (MI)......
目的：肥胖与心血管疾病的发生有密切联系,本文探讨游泳运动对高脂饮食诱导的心脏功能的影响,并且研究calpain参与的机制。方法： 6周......
目的：通过观察补充海洋胶原肽对股中肌Calpain-1、Calpain-2基因表达的影响来探讨活性肽在预防骨骼肌蛋白降解中所发挥的作用,为开......
Poly(ADP-ribose)polymerase (PARP), calpain and nuclear factor-κB (NF-κB) are reported to participate in inflammatory r......
BACKGROUND: Arsenic is a well-known environmental contaminant [1].Chronic exposure to arsenic is known to increase the r......
Calpain Inhibitor Reduces Cancer-induced Bone Pain Possibly Through Inhibition of Osteoclastogenesis
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Protective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear
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Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury
The protein levels and activities of calpain-1 and calpain-2 are increased in cardiac mitochondria under pathological co......
研究目的：运动员大负荷运动后会造成骨骼肌超微结构损伤,使得骨骼肌收缩能力下降,进而还可能导致运动疲劳,运动竞技能力下降,因......
目的:探讨钙中性蛋白酶2(calpain2)及其抑制剂calpastatin在肝纤维化过程中的表达变化及他们在肝细胞凋亡中的作用。方法:雄性Wist......
目的观察20(R)-人参皂苷Rg_3对大鼠缺血再灌注后迟发性神经元损伤的保护作用并探讨其作用机制。方法将健康雄性SD大鼠随机分为:假......
目的 通过比较钙蛋白酶 (calpain)和钙蛋白酶抑制蛋白 (calpastatin)mRNA在类风湿关节炎 (RA)和骨关节炎 (OA)滑膜上的表达以及人......
目的:通过观察心脏骤停家猪心肌氨基末端激酶(JNK)、caspase-12、钙蛋白酶(calpain)mRNA水平及蛋白表达,以及超微结构的变化,探讨......
多聚谷氨酰胺疾病是由CAG三核苷酸重复扩增并编码多聚谷氨酰胺链而致病的一类疾病,目前推测其发病与蛋白错误折叠、蛋白-蛋白相互......
目的探讨CalpainI蛋白和细胞调亡在心房结构重构中的关系和作用。方法选择行换瓣手术的风湿性心脏病患者,在外科手术中取其左心房......
目的:探讨钙蛋白酶10基因多态性与原发性高血压遗传易感性的关系。方法:采用病例对照研究设计,以聚合酶链式反应-等位基因特异性扩......
Variations in the calpain-10 gene are associated with the risk of type 2 diabetes and hypertension i
Background Calpain-10(CAPN10)has been identified as a susceptibility gene in type 2 diabetes mellitus(T2DM)andinsulin r......
目的模拟肺静脉自行发放高频脉冲建立心房颤动的动物模型,研究肺静脉及左心房的CalpainⅠ重构情况,以期阐明CalpainⅠ的变化在持续......
OBJECTIVE To explore the role of calpain in in pulmonary vascular remodeling in hypoxia induced pulmonary hypertension a......
缺血-再灌注(I-R)可引起肌膜损伤、Na+/Ca2+交换逆转以及肌(内)质网钙泵(SERCA)含量或活性下降从而导致心肌钙超载。钙超载诱导心......
目的:探讨1次离心运动后大鼠骨骼肌超微结构、Calpains和Ubiquitin的动态变化.方法:30只雄性SD大鼠随机分为对照组和1次离心运动后......
Calpains are a group of calcium-dependent proteases that are over activated by increased intracellular calcium levels un......
目的研究苦参素对实验性自身免疫性脑脊髓炎(EAE)大鼠钙蛋白酶(Calpain)和微管相关蛋白2(MAP-2)表达的影响。方法采用随机数字表法......
目的 探讨钙蛋白酶抑制剂calpeptin在机械通气所致膈肌损伤和膈肌萎缩中的作用.方法 将24只SPF级雄性SD大鼠按随机数字表法分为麻......
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目的:本项目分别使用不同的钙离子通道抑制剂工具药和构建CAPNS1基因敲除SK-N-SH细胞模型(CAPNS1-/-)来研究calpain在三邻甲苯基磷......
