Aims: To explore the transcription factors and related signal transduction pathways activated in the alkylating agents N......

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This work aims to investigate the role of the loopβ3αC amino acids in the structure and function of isocitrate dehydro......

TAK1 plays an easential role in proinflammatory cytokine TNFα and IL-1β-induced IKK/NF-κB and JNK/AP-1 activation.Her......

Isocitrate dehydrogenase kinase/phosphatase(AceK)is a bifunctional enzyme with both kinase and phosphatase activities th......

Protein phosphorylation is one of the most important and essential post-translational modifications (PTMs).It plays a cr......

Kinases and GTPases,the major players in cell signaling pathways,control diverse biological processes in a precisely con......

Protein kinases and their substrates represent the largest signaling network that regulates protein-protein interactions......

背景:50%以上胶质母细胞瘤(Glioblastoma,GBM)中存在表皮生长因子受体(Epidermal growth factor receptor,EGFR)过表达或突变,但EG......

Auxin acts as a key hormone in plant that determines many developmental processes by the typical concentration dependent......

OBJECTIVE Aryl hydrocarbon receptor(Ahr)is thought to be a crucial factor that regulates immune responses,which may be i......

OBJECTIVE N2L is a novel lipoic acid-niacin dimer regulating lipid metabolism with multifunction,including antioxidant e......

Metabolic syndrome is a pre-diabetic state characterized by several biochemical and physiological alterations,including ......

Chronic myeloid leukemia (CML) associated with pregnancy is a very rare situation (less than one case per 100</span></sp......

BACKGROUND The understanding regarding genetic variation,pathophysiology,and complications associated with pyruvate kina......

BACKGROUND Gastric cancer is the fifth most diagnosed cancer worldwide and the third most common cause of cancer-related......

BACKGROUND Rearrangements of the anaplastic lymphoma kinase(ALK)gene(ALK-positive)represent an oncogenic driver in appro......

BACKGROUND Histological transformation is one of the numerous mechanisms of acquired resistance to epidermal growth fact......

BACKGROUND Primary anaplastic large cell lymphoma of the lung represents a diagnostic challenge due to diverse manifesta......

BACKGROUND Osimertinib is the recommended first-line treatment for adult patients with epidermal growth factor receptor(......

Background: Preeclampsia (PE) is still one of the leading causes of maternal/perinatal morbidity/mortality in Nigeria. I......

India is no exception to the economic setback due to coronavirus disease 2019 (COVID-19). Loss of jobs and income dramat......

Beige adipocytes have been considered as a potential strategy in anti-obesity therapy because of its thermogenic capacit......

　　Protein kinases and their substrates comprise extensive signaling networks that regulate many diverse cellular funct......

Activity-based chemical probes (ABPs) have gained significant interests in both chemical biology and drug discovery rese......

　　Protein function originates from a cooperation of structural rigidity,dynamics at different timescales and allostery......

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　　The great abundance of cellulose places it at the forefront as a primary source of biomass for a renewable energy so......

Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tu......

Objective:To assess the therapeutic potential of ethanolic extract of Azadirachta(A.)indica in rats with polycystic ovar......

Many of the effects of Ca2+ signaling are mediated through the Ca2+/calmodulin complex and its acceptors, the Ca2+/calmo......

A novel full-length cDNA encoding a putative serine/threonine kinase has been isolated from a human testis cDNA library.......

Protein kinase B (PKB) is a member of the second messenger-regulated subfamily of protein kinases, and plays a key role ......

To explore correlation between the tk gene structure of pseudorabies virus (PRV) and its virulence, to study the effect ......

Fibronectin, a major extracellular matrix, plays an important role in embryo implantation by mediating embryo adhesion a......

The kinetic theory of the substrate reaction during the modification of enzyme activity previously described by Tsou has......

The cyanolysis of DTNB-modified creatine kinase(S,S’-di-TNB-CK)has been studied.Itwas found that there exist both cyano......

Six hybridoma cell lines that can continuously secrete monoclonal antibodies against adenylate kinase (AK) have been pro......

Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects,including cell growth,differentiat......

Objective To explore the molecular mechanism of insulin resistance in the patients with polycystic ovarian syndrome (PC......

[Objective] To observe the effects of total flavonoids in Drynaria fortunei (Kunze) J. Sm. (TFDF) on osteoblasts (OB) di......

The purpose of this study was to investigate the changes of protein kinase Cα(PKCα) and cyclin D1 expressions in pulmo......

研究铅及蛋白激酶C的激活剂在收缩过程中对钙信号系统的影响。制各家兔肠系膜动脉血管条，悬吊于浴槽中．其张力变化经换能并放大后描......

Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of can......

越来越多的研究结果表明2型糖尿病(Type 2 Diabetes Mellitus,T2DM)的发生与自身免疫机制有关,糖尿病肾病(Diabetic Nephropathy,D......

Objective To document the possible effect of tyrosine kinase autophosphorylation on erythrocyte insulin-receptor after 1......

Objective: It is well known that systemic insulin resistance (IR) is closely associated with the metabolic syndrome incl......

ROCK也称Rho相关激酶(Rho-Associated Kinase),简称Rho激酶(Rho Kinase),作为一种丝氨酸/苏氨酸蛋白激酶,是小G蛋白(Small G Prote......

动脉粥样硬化(Atherosclerosis,AS)是心脑血管疾病的重要病理生理基础,近年来,大量人体和动物实验研究表明,5-脂氧合酶(5-Lipoxyge......

AIM To study the relationship of jailed polymer jacketed guide wires(PGW) with procedural myocardial infarction(PMI) aft......