A great challenge in cancer diagnosis is to locally recognize the cancer cells at the molecular level with highly specific biomarkers for maximum therapeutic benefit(1).Current cancer research has focused on identifying biomarkers that are highly specific to a particular phenotype(2).One of the key applications includes detection of the circulating tumor cells(CTC)from whole blood.The current CTC characterization based on molecular biomarkers has been hampered by limitations in specificity and their low concentration in blood.A major hurdle of using the molecular biomarkers originates from the similarities in genetic expressions between the cancer and normal cells.Therefore,new targeting strategies are critically needed to address this issue through characterization of the bio-physical properties of cancer cells.