RGD相关论文
目的:目前治疗牙列缺损和缺失的首选方案是进行种植牙手术,对种植体表面进行改性能有效提高种植体与周围骨之间的骨结合。种植体表......
目的:评价去卵巢大鼠骨质丢失情况,建立理想的骨质疏松症动物模型。方法:取8-10周龄雌性Wistar大鼠56只,分为去卵巢组和对照组,其......
Schwann cells play a key role in peripheral nerve growth and regeneration. The aim of this study was to evaluate the eff......
Preparation and Characterization of an Intelligent Multi-target Tracking HA-RGD-CLB-QDs Drug Deliver
This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGD-chlorambucil-quantum dots (HA-RGD-CL......
Hyaluronic Acid-RGD Peptide Conjugated Mesoporous Silica-coated Gold Nanorods for Cancer Dual-target
A multifunctional drug delivery system (GNRs@mSiO2-HA-RGD) was developed by conjugating targeting ligand hyaluronic acid......
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RGD-Functionalized Ultrasmall Iron Oxide Nanoparticles for Targeted T1-Weighted MR Imaging of Glioma
Objective: Among various magnetic nanoparticles(NPs),Fe3O4 NPs have been extensively investigated due to their excellent......
Application of nanobiotechnology to deliver therapeutic drugs selectively to diseased sites with imp
A number of drugs only give rise to limited clinical response when causing remarkable toxicities due to wide distributio......
Osteosarcoma is the most common primary malignant bone tumor in the pediatric age group, and chemotherapy directed by ta......
Non-invasive in vivo diagnosis of brain glioma using RGD decorated fluorescent carbonaceous nanosphe
Carbon nanomaterials,including graphene,carbon nanotubes,fullerene and fluorescent carbonaceous nanospheres (CDs),have b......
A in To on firm thence hanism of AoGDW(ω-amincotanoicaid-gdyine-aspacticaid-tryptophan) inhibiting platelet aggregation......
Study on the construction and in-vitro anti-tumor efficiency of RGD and thiolytic cleavable PEG co-m
To enhance targeting ability and reduce non-specific uptake of drug delivery system for cancer therapy, a smart anti-tum......
RGD-mediated,chitosan modified single-walled carbon nanotubes for docetaxel targeting delivery to in
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Pharmacology,pharmacokinetics and toxicology of a novel antithrombotic peptidomimetic inhibitor ωRWR
ωRWR is a new patented antithrombotic small peptide which exhibits anti-coagulation effects by competitively inhibiting......
In recent years,the cancer is still one of the diseases that threaten humans lives.As an antitumor antibiotic,Doxorubici......
Low-molecular polyethyleneimine modified with pluronic 123 and RGD-or chimeric RGD-NLS peptide: char
To solve the problem of transfection efficiency versus cytotoxicity and tumor-targeting ability when polyethylenimine (P......
为了系统的研究野蚕丝素蛋白中含RGD多肽的基因序列与其生物功能的关系,为其应用于生物材料奠定理论基础,设计了编码来自柞蚕(天蚕......
正电子发射型计算机断层显像(Positron Emission Tomography,PET),是核医学领域比较先进的临床检查影像技术,具有灵敏度高,特异性......
Study of pertechnetate labeling cyclic RGD peptide and imaging its distribution in nude mice with xe
Objective: To label the Arg-Gly-Asp containing peptide RGD which specificly bind with αvβ3 receptor expressed in tumor......
99mTc-3PRGD2 imaging study in evaluating the effect of anti-angiogenesis therapy in nude mice bearin
Objective: For targeted therapy of tumor angiogenesis is a hot research at home and abroad and anti-tumor drugs is an im......
Objective: Studied Semi-automated synthesis methods to link radionuclide 18F to Cyclic arginine-glycine-aspartat (RGD) p......
在组织工程支架中预先构建微血管网络，是保证植入人体的人工组织发挥正常生理功能的关键问题，但过度血管化则有癌变风险。为了解决这......
在光动力治疗的过程中，提高光敏剂对肿瘤细胞的选择性是一个非常重要的课题.本文设计合成了RGD环肽(RGDyK)与锌酞菁(ZnPc)相连的新......
Anticoagulants and anti-platelet agents are simultaneously administrated in clinical practice(i.e.percutaneous coronary ......
Micro-positron emission tomography imaging of angiogenesis based on ^(18)F-RGD for assessing liver m
Background:Positron emission tomography (PET) imaging is a non-invasive method to visualize and quantify the tumor micro......
The RGD sequence generally exists in the extracellular matrix proteins and can be recognized by many integrin proteins. ......
用含RGD及K16肽改性仿生PLGA-（ASP-PEG）基质材料表面，骨髓基质干细胞（BMSCs）接种于改性材料表面，观察该表面对MsCs黏附及分化影响。分离......
Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of patho......
<正>将含有C16或C18脂肪酸链的两亲性多肽通过1或2个ADA与RGD交联,得到了4种新型RGD修饰的两亲性多肽(PAs)。4种PAs的临界胶束浓度......
人体中的诸多化学反应，对人体自身都会产生重要影响，研究水溶液中受体和配体之间的结合自由能具有重要意义。我们首先从PDB 数据......
通过高温热解法合成了蓝色的四方双锥型TiO2 纳米粒子。然后通过Click 反应，进行PEG 水溶性改性及后期的靶向功能化，得到了生物......
目的:探讨穴区细胞外基质在针刺信号转导中的作用机制.方法:SD大鼠40只,雌雄各半,随机分为4组,每组10只,以大鼠热辐射甩尾实验的温......
Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in v
AIM: To investigate the effect of arg-gly-asp-mannose-6phosphate (RGD-M6P) on the activation and proliferation of primar......
rLj-RGD3是来源于日本七鳃鳗口腔腺的基因重组RGD毒素蛋白,含有3个RGD序列,分子量为14.5 kDa。前期工作表明,rLj-RGD3具有强效抗肿......
与血管生成相关的疾病如实体肿瘤、眼部血管增生类疾病是研究工作中一类热点疾病,抑制新生血管的生成是治疗此类疾病的首要选择。......
本课题基于聚乙二醇1000维生素E琥珀酸酯(TPGS)和维生素E琥珀酸酯(VES)改性壳寡糖(CSO)的优良特性,以及RGD序列多肽可以特异性靶向......
对细胞粘附和迁移的远程、时空和可逆控制对于许多生物技术应用和细胞疗法是非常重要的实现手段。在本文中,我们展示了在修饰有插......
猪圆环病毒2型(Porcine Circovirus Type 2,PCV2)可引起猪圆环病毒相关疾病(Porcine Circovirus Associated Diseases,PCVAD),在世......
目的乳腺癌是严重威胁女性生命健康的恶性肿瘤之一,发病率呈逐年递增的趋势,已居女性癌症发病率的首位。三阴性乳腺癌(TNBC)是一种......
研究目的:利用抗癌肽D-K6L9修饰RGD和NGR,获得RKL和NKL。利用荧光染料sulfo-Cy5.5-NHS酯标记新型探针,通过细胞免疫荧光试验和荷瘤......
骨桥蛋白 (osteopontin,OPN)是一种磷酸化糖蛋白 ,在一些正常组织中少量表达 ,但在许多癌组织中表达量增加 ,它特别与肿瘤的浸润与......
在种植牙治疗中,种植体植入后需经过约3~6个月的骨整合期,才能开始上部修复体制作。同时,在完成种植牙治疗后可能因骨结合欠佳而发......
目的探讨精氨酸-甘氨酸-天冬氨酸(RGD)肽修饰纯钛表面对人牙龈成纤维细胞(human gingival fibroblasts,HGF)和上皮细胞(humangin g......
介绍了爆炸性减压的机理特性及其对阀门密封件损害的形态与过程。分析了爆炸性减压与阀门密封结构、材料特性、制造工艺及其操作条......
