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39. Ultrastructural Changes of Neurons Located at Anterior Horn of Lumbar Spinal cord in Ethylene Ox
Mice inhaled ethylene oxide at concentration of 360 mg/m3 for two hours a day, six days a week for 14 weeks. At the end ......
A New Curcumin Analogue Exhibit Enhanced Anti-Tumor Activity in Nasopharyngeal Carcinoma via Activat
[Purpose] Nasopharyngeal carcinoma (NPC) is the most common malignant tumor in Southeast Asia and radio-resistance remai......
Trapping endoplasmic reticulum with amphiphilic AIE-active sensor via specific interaction of ATP-se
The current aggregation-induced emission luminogens(AIEgens) sometimes suffer from poor targeting selectivity due to und......
Neointimal hyperplasia after vascular injury is a representative complication of restenosis.Endoplasmic reticulum(ER)str......
Structural changes of oviduct of freshwater shrimp, Macrobrachium nipponense (Decapoda,Palaemonidae)
The structural change of the oviduct of freshwater shrimp (Macrobrachium nipponense) during spawning was ex- amined by e......
Nonalcoholic fatty liver disease(NAFLD)has emerged as a common public health problem in recent decades.However,the under......
A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesio......
Viral hepatitis remains a worldwide public health problem.The hepatitis D virus(HDV)must either coinfect or superinfect ......
Serum palmitic acid(PA), a type of saturated fatty acid, causes lipid accumulation and induces toxicity in hepatocytes.E......
Pancreatitis is an increasingly common and sometimes severe disease that lacks a specific therapy.The pathogenesis of pa......
Celastrol is a pentacyclic triterpenoid isolated from Tripterygium wilfordii that has long been used in traditional Chin......
FKBP23 was found in mouse endoplasmic reticulum (ER) in 1998. It consists of an N-terminal peptidyl-prolyl cis-trans iso......
The sarcoplasmic reticulum (SR) Ca2+-ATPase was purified and reconstituted into the sealed phospholipids vesicles with o......
Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the most abundant sterol in mammals......
Layer by layer surface engineering of poly (lactide-co-glycolide) nanoparticles:A versatile tool for
Recent work regarding the Layer by Layer (LbL) engineering of poly(lactide-co-glycolide) nanoparticles (PLGA NPs) is rev......
Rotaviruses are the single leading cause of life-threatening diarrhea affecting children under 5 years of age. Rotavirus......
The molecular mechanism of how hepatocytes maintaincholesterol homeostasis has become much more transparentwith the dis......
Ca~(2+)sparks are the elementary units of intracellular Ca~(2+)signaling in striated musclecells revealed as localized ......
Angiotensin Ⅱ receptor blocker provides pancreatic β-cell protection independent of blood pressure l
Aim:Several epidemiological studies have suggested that treatment with angio-tensin Ⅱ type 1 receptor blocker provided......
Dear Editor:Geldanamycin is a benzoquinone ansamycin,which wasoriginally described as a tyrosine kinase inhibitor.How-e......
Proliferation and C-myc Gene Expression of Smooth Muscle Cells in Rabbit Carotid Artery after Stenti
Objectives To investigate theproliferation of smooth muscle cells (VSMCs) and theexpression of c-myc gene in rabbit car......
The Effect of Extrogenous Phosphocreatine on L-type Calcium Current in Ischemic Guinea Pig Ventricul
Objectives Heart failure (HF)is one of the most common outcome for all kinds of heartdiseases, the effects of energetic ......
Both environmental and genetic factors contribute to the development of diabetes mellitus and although monogenic disorde......
Transforming Growth Factor-β1 Induces Transdifferentiation of Fibroblasts into Myofibroblasts in Hyp
The muscularization of non-muscular pulmonary arterioles is an important pathological featureof hypoxic pulmonary vascu......
Objective To investigate the effects of losartan on mRNA expression of myocardial sarcoplasmic reticulum calcium handlin......
G6PT-H6PDH-11βHSD1 triad in the liver and its implication in the pathomechanism of the metabolic syn
The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiome......
Increased cardiac release of norepinephrine (NE) and depleted cardiac stores ofNE are two salient features of the human......
Reversal of isoproterenol-induced downregulation of phospholamban and FKBP12.6 by CPU0213-mediated a
Aim:The downregutation of phospholamban (PLB) and FKBP12.6 as a result of β-receptor activation is involved in the pat......
Phospholamban Antisense RNA Improves SR Ca~(2+)-ATPase Activity and Left Ventricular Function in STZ
Objective To study the effect of phospholamban antisense RNA (asPLB) on sarcoplasmic reticulum Ca2+-ATPase activity and ......
There is a growing body of evidence that Diabetes Mellitus leads to a specific cardiomyopathy apart from vascular diseas......
Neuroglial cells are homeostatic neural cells. Generally, they are electrically non-excitable and their activation is as......
Inositol requiring enzyme-1(IRE1)is highly conserved from yeasts to humans.Upon endoplasmic reticulum(ER)stress,IRE1 act......
Expression of human hepatic lipase negatively impacts apolipoprotein A-Ⅰ production in primary hepat
This study aimed to examine whether expression of human hepatic lipase(hHL) exerted an intracellular effect on hepatic p......
Objective To demonstrate the myocardial lesion associated with long-term administration of methamphetamine in rats. Meth......
Cardiac dysfunction is a well-known consequence of diabetes,with sustained hyperglycaemia leading to the development of ......
Diabetes mellitus(DM) is characterised by hyperglycemia, insulin resistance and metabolic dysregulation leading to diast......
AIM: To investigate the gastric muscle injury caused by endoplasmic reticulum(ER) stress in rats with diabetic gastropar......
Calcium release from sarcoplasmic reticulum (SR) though Ryanodine receptors plays an important role in excitation contra......
Objective To investigate the protective effect of zinc in CCl4-induced hepatotoxicity. Methods Rats were treated with ......
Currently,60 million women of reproductive age(18-44 years old) worldwide,and approximately 3 million American women hav......
目的:研究SERCA2a mRNA在左心室机械辅助减负荷模型中的表达及其意义,探讨左心室减负荷后心肌分子水平的变化。方法:选用Lewis大鼠......
Myocardium injury after burn with complicating sepsis about the IL-6 deficiency mice at different ag
Concerning SIRS injury carries a disproportionately high morbidity and mortality in the elderly to re-search whether Int......
Adiponectin Attenuates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury Through Inhibition of Endo
Background and Aim Adiponectin(APN) is a potent cardioprotective molecule.The present study aims to investigate the unde......
The incidence of obesity has dramatically increased in recent years.Consequently,obesity and associated disorders such a......
The past five years have witnessed the discovery of the endoplasmic reticulum calcium(Ca2+) sensor STIM1 and the plasma ......
胰岛β细胞具有高度发达的内质网，对内质网应激（endoplasmic reticulum stress，ERS）非常敏感。多种因素可以打破内质网稳态，引起蛋白质......
Effects of endoplasmic reticulum stressmediated apoptosis in intimal calcification of diabetic apoE~
Objective To investigate the role of endoplasmic reticulum stress(ERS)-mediated apoptosis in athero-scle-rotic calcifica......
