calcineurin相关论文
研究一 4型心肾综合征中心肌miR-30的表达目的:确定4型心肾综合征中心肌组织miR-30表达是否出现改变方法:（1）7/8肾切除术构建大鼠4型......
Ⅰ型干扰素在抗病毒天然免疫反应中发挥着重要作用。当病毒侵染机体时,首先会被宿主的模式识别受体（Pattern recognition receptors......
目的 以钙调蛋白磷酸酶(CN)为靶酶,从中草药中寻找高效、低毒的免疫抑制剂.方法 以CN为靶点,筛选并分离能够抑制其活性的天然化合......
Cloning and Functional Analysis of Calcineurin Subunits A and B in Development and Fecundity of Nila
Serine/threonine phosphatase calcineurin (CN) is a unique but confounding calcium/calmodulin-mediated enzyme,which is co......
心脏2型兰尼碱受体（ryanodine receptor type 2,RyR2）分布于心肌肌浆网,在兴奋收缩耦联水平调控Ca2+的释放。RyR抑制剂dantrolene最......
足细胞损伤是肾脏疾病发生发展的中心环节,足细胞是肾小球脏层上皮细胞,附于肾小球基底膜表面,是肾小球滤过屏障的重要组成,它功能......
Objective: To investigate the effects of evodiamine (Evo), a component of Evodiaminedia rutaecarpa (Juss.) Benth, on car......
TRPV1 induced apoptosis of colorectal cancer cells by activating calcineurin-NFAT2-p53 signaling pat
Objective Colorectal cancer(CRC)is one of the common malignant tumors of digestive system and its incidence is increasin......
Protopanaxadiol ginsenoside-Rd protects against NMDA receptor-mediated neuronal injury by inhibiting
...
Bone marrow mesenchymal stem cells reversed potassium channels remodeling in post-infarcted myocardi
Aim: Bone marrow mesenchymal stem cells (BMSCs) emerge as a new promising approach for treating heart diseases.However, ......
The new immunosuppressant,quercitrin,inhibits calcineurin,and suppresses immunity through the CN-NFA
Quercitrin is a natural compound.It is extracted from the flowers of Albizzia julibrissin Durazz and is an inhibitor of ......
Aim: Cardiac hypertrophy is a primary predicator of progressive heart disease that often results in heart failure.This s......
活化T细胞核因子（NFAT）在许多免疫细胞中表达。在细胞因子基因和其它一些对免疫反应很重要的基因转录中起关键作用。NFAT蛋白活性受......
The role of calcineurin in the lung fibroblasts proliferation and collagen synthesis induced by basi
...
The signal transduction pathway in the proliferation of airway smooth muscle cells induced by uroten
...
Calcineurin is involved in cardioprotection induced by ischemic postconditioning through attenuating
...
The coronavirus disease 2019(COVID-19)caused by severe acute respiratory disease respiratory syndrome coronavirus-2 has ......
Calcineurin (CN), a unique protein phosphatase, plays an important role in immune regulation.In this study we used C......
Isogarcinol the bioactive polyisoprenylated benzophenone derivative was isolated from Garcinia mangostana L..In our ......
Buckwheat Rutin Exhibited inhibitory effect on Angiotensin Ⅱ-induced Proliferation of Fibroblasts by
Studies have found that buckwheat rutin could inhibit proliferation of cardiac fibroblasts induced by angiotensin II, bu......
结果证明 calcineurin 在马头鱼尾的怪兽在长期的 potentiatibn (LTP ) 起一个作用。45 ku 酶被管理，它从老鼠马头鱼尾的怪兽的没有......
本文报导了一种能同时纯化钙调神经磷酸酶和钙调素的有效方法。牛脑粗提液经DE-52纤维素层析分段洗脱:0.5mol/L NaCl缓冲液洗脱峰......
X-band electron spin resonance spectroscopy was used to investigate the binding of Mn<sup>2+</sup>tothe apo-forms of cal......
目的:研究CPU86017及其旋光异构体对L-甲状腺素致大鼠心肌病异常的calcineurin和NFκB基因改变,并比较CPU86017及其旋光异构体对它......
Transplantation in children is the best option to treat renal failure. Over the last 25 years the improvements in therap......
蛋白尿是儿童肾脏疾病最为常见的临床症状,在其发生和进展的分子机制中,足细胞起到非常重要的作用,越来越多的足细胞相关分子已经......
钙调神经磷酸酶(calcineurin,CaN)是Ca2+的下游因子,在细胞内钙升高引起的心肌肥大中有重要作用。现综述Ca2+CaN及其下游因子活化T......
钙调神经磷酸酶（calcineurin，CaN），是迄今所知的惟一一种受Ca^2＋／钙调蛋白（calmodulin，CaM）调节的丝氨酸／苏氨酸蛋白磷酸酶。CaN广泛分布于机......
Changes of Expression of Stretch-activated Potassium Channel TREK-1 mRNA and Protein in Hypertrophic
The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. U......
Effect of cyclosporine-A on electrophysiological properties of atria in tachycardia-induced atrial f
Objective To investigate the effects ofciyclosporine-A (CsA),a calcineurin (CAN) inhibitor,on electrophysiological prope......
Recent advances in the management of lupus nephritis,together with earlier renal biopsy and selective use of aggressive ......
The incidence of obesity has dramatically increased in recent years.Consequently,obesity and associated disorders such a......
Molecular mechanisms and therapeutic perspectives of left ventricular hypertrophy in systemic hypert
Background Left ventricular hypertrophy(LVH) induced by systemic hypertension represents a maladaptive response to the i......
Calcineurin (CN) is the only protein phosphatase known to be under the control of calcium (Ca2+) and calmodulin (CaM). ......
...
...
目的 观察在炎症因子γ-干扰素和CD40配体刺激下大鼠血管平滑肌细胞的凋亡及钙调神经磷酸酶活性和表达水平的变化,进一步探讨血管......
目的探讨氟对大鼠骨组织中破骨细胞的作用及其调节机制。方法将20只清洁雄性3周龄Wistar大鼠，按体重采用随机数字表法分为两组，每组1......
目的 探讨瓣膜病患者钙调神经磷酸酶-活化T细胞核因子通路(CaN-NFAT通路)与心房纤颤的关系.方法 选择因瓣膜病接受换瓣手术治疗患......
钙离子介导的信号通路(Ca2+signaling pathway)广泛地参与了真核生物中的各种生理活动过程,包括生长发育、细胞分裂、分化、程序性......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
WT5”BZ] To study the molecular mechanism of the stimulatory effect of low dose radiation(LDR) on T cell......
BACKGROUND: The high concentration of glutamate release is the main cause for neuronal cell death. The relationship betw......
Cytomegalovirus infection in severe ulcerative colitis patients undergoing continuous intravenous cy
AIM: To investigate active cytomegalovirus (CMV) infection following the cyclosporine A (CyA) treatment of steroid-refra......
Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in u
AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,......
Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adu
Inflammatory bowel diseases(IBDs) are a group of chronic inflammatory conditions mainly of the colon and small intestine......
