thalidomide相关论文
目的 观察沙利度胺(THD)对人宫颈癌Hela细胞周期形成的影响?方法 利用不同浓度的THD(50μg/mL?100μg/mL与200μg/mL)处理人宫颈癌......
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Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma: A
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A rapid, sensitive, and specific analytical method based on high-performance liquid chromatography-tandem mass spectrome......
Primitive neuroectodermal tumors(PNETs)are small round cell tumors,which originates from primitive neuroectodermal and b......
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Thalidomide Effects in Patients with Hereditary Hemorrhagic Telangiectasia During Therapeutic Treatm
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Celgene公司1月9日宣布,药物沙利度胺(thalidomide, Thalomid)的关键期研究提前终止,因为实验显示该药可显著抑制多发性骨髓瘤的进......
Weber-Christian disease(WCD) is an inflammatory disease whose main histological feature is lobular panniculitis of adipo......
目的观察沙利度胺联合TP方案对比单纯TP方案治疗晚期非小细胞肺癌的疗效和安全性。方法将70例晚期非小细胞肺癌患者随机分为对照组......
五十年代有人报道服用安眠药 Thalidomide 后有致畸胎副作用事例,以后人们更重视药物的致畸胎副作用。迄今,已知有致畸胎副作用的......
在60年代,当反应停(酞咪哌啶酮thalidomide)的危害明显时,大家注意到孕妇服药可能造成胎儿畸形。表1所示为已确定能引起胚胎及胎......
出生缺陷(birth defects)系指先天的躯体畸形和功能缺陷,包括遗传性疾病和胚胎在发育过程中受致畸突变因子作用而致的发育异常,以......
反应停(Thalidomide)是我国开始自产并试用于治疗麻风病反应的新药。其副作用有口干、头昏、倦怠、恶心、腹痛、局部浮肿、肠鸣、......
反应停(Thalidomide)的致畸胎作用曾在许多国家酿成灾难,但在我国尚未见反应停致畸胎的报告。现将我院一例报告如下。病人袁某某,......
反应停(Thalidomide)能有效地治疗瘤型麻风的结节性红斑(ENL)反应,但ENL的发病机理尚不明,曾推测它由于或至少是伴有T细胞亚群急......
The teratogenicity of 5-fluoro-2’-deoxyuridine (FdU) is well established. Previously, we have demonstrated that teratog......
自从以色列的Sheskin首次报告反应停(Thalidomide)治疗麻风性结节性红斑(ENL)反应效果良好以来,全世界都证实了这一发现。此外反......
自发性溃疡是HIV感染的常见表现，溃疡多见于口咽和食管，也可见于直肠和外阴。6O％的病例找不到发生生殖器溃疡的原因。皮质激素对口咽......
AIM: To assess the efficacy and tolerability of thalidomide in pediatric Crohn’s disease (CD). METHODS: Six patients wi......
Vascular injury or interruption may play a role in vertebrate limb teratogenesis. Since 5fluoro- 2’- deoxyuridine (FdU)......
已证明酞胺哌啶酮(thaljdomjde)治疗慢性盘状红斑狼疮(CDLE)、抗疟药耐药性 CDLE、亚急性皮肤红斑狼疮和深部红斑狼疮有效,而治疗......
反应停(Thalidomide)是一种低毒无成瘾性的中枢神经镇静剂,在50、60年代风靡一时,后因其致畸胎作用消声匿迹了一段时间。60年代初......
Thalidomide treats multiple myeloma and protracts life-span of patient, but its bioavailability is limited as it is poor......
In search of novel anticancer agents,a series of thalidomide analogs(6a-j)were designed and synthesized.Cytotoxicity of ......
Novel phthalimide derivatives(4a,4b and 6a-6e)were designed as hybrids of thalidomide and NO-ASA,and their chemical synt......
AIM:To review pediatric cases of orofacial granulomatosis(OFG),report disease characteristics,and explore the associatio......
目的观察沙利度胺(Thalidomide反应停)用于缓解化疗病人恶心、呕吐的临床疗效。方法将53例恶性肿瘤患者(包括乳腺癌、肺癌、大肠癌......
AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn’s disease(CD) with tuberc......
Adamantiades-Behcet’s disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent......
Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma (MM), it is very rarely detec......
Multiple myeloma remains incurable with conventional treatments.However,new active drugs,including the immunomodulatory ......
The frequency of diagnosis of inflammatory bowel disease(IBD) has increased in younger populations.For this reason,pregn......
临床试验表明,反应停(thalidomide)用于治疗多发性骨髓瘤(MM),特别是难治性和复发性MM取得了良好的效果。反应停治疗MM的机制尚不......
血液系统恶性疾病的发生、发展和预后与血管新生密切相关,抗血管生成治疗已成为肿瘤治疗的热点之一。研究发现,曾因致畸作用而被禁......
195 3年 ,瑞士的Ciba药厂合成了反应停(thalidomide) ,并于 195 7年作为镇静催眠和治疗妊娠早期呕吐药而被推向市场。但 196 1年澳......
AIM:To evaluate the clinical benefit of thalidomide in patientswith advanced hepatocellular carcinoma (hepatoma).METHOD......
目的 报告1例IgE骨髓瘤病例并将其临床特征与文献进行比较。方法 对1例骨髓瘤患者的血清尿液采用醋酸纤维膜电泳、免疫固定电泳和......
目的探讨沙利度胺联合VAD方案治疗老年多发性骨髓瘤（mulitiplemyeloma，MM）的临床疗效及用药安全性。方法将76例老年MM患者采用数字表......
目的 观察沙立度胺对人乳腺癌细胞系MCF-7、MDA-MB-231细胞血管内皮生长因子(VEGF)表达的抑制作用.方法 应用半定量逆转录-聚合酶......
目的观察应用小剂量沙利度胺联合含小剂量地塞米松的VAD方案治疗老年人多发性骨髓瘤(MM)的疗效。方法将58例纳入研究的病例进行随......
目的：观察亚砷酸(ATO)联合反应停、维生素C (VitC)治疗难治性复发性多发性骨髓瘤(MM)的疗效及安全性。方法：19例难治复发MM患者，应用......
多发性骨髓瘤（ MM）伴发周围神经病变主要表现为进行性、对称性的四肢远端感觉及运动障碍。目前对于周围神经病变发生的机制尚不清楚，......
目的探讨沙利度胺联合mFOLFOX方案治疗晚期结肠癌的疗效、安全性及其对血清血管内皮生长因子（VEGF)的影响。方法100例晚期结肠癌患......
原发性肝癌是一种恶性程度较高的肿瘤,约70%患者发现时已属中晚期,病变广泛或已有转移,并多伴有肝硬化,不能手术切除[1] .随着肿瘤......
目的探讨沙利度胺对百草枯（PQ）中毒急性肺损伤（ALI）大鼠的保护作用及其可能机制。方法将60只SPF级Wistar大鼠按随机数字表法分为6组，每......
