TELOMERE相关论文
Meiosis is the key process for producing mature gametes.A natural fertile triploid Carassius auratus population (3nDTCC)......
Aim: To simultaneously determine the localization of histones and protamines within human sperm nuclei. Methods: Immunof......
Retrospective descriptive analysis of the physiological kinetics of prostate-specific antigen in men
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Sperm are a highly specialized cell type derived to deliver the paternal haploid genome to the oocyte. The epigenetic,or......
Influencing factors of relative telomere length in workers occupationally exposed to organophosphate
Objective: The study was designed to assess the change of relative telomere length(RTL) in workers occupationally expose......
Suppression of Telomere-Binding Protein TPPI Resulted in Telomere Dysfunction and Enhanced Radiation
Mammalian telomeres are protected by the shelterin complex that contains the six core proteins POT 1, TPP1, TIN2, TRF1, ......
A comparative study on human telomeric DNA G-quadruplex binding of meso-5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin......
Trigeminal star-like platinum complexes selectively induce G-quadruplex-mediated telomeric DNA damag
Two trigeminal star-like platinum complexes were designed and synthesized as excellent hTel G4 stabilizers with high aff......
Design, Synthesis of Novel oxo-heterocylic naphtalimides and Their Interaction with guanine-rich tel
Telomeres are significant structures at the end of chromosomes,which play an essential role in various biological events......
Single-molecule study reveals the folding mechanisms of DNA G-quadruplexes,and how they are regulate
G-quadruplexes(G4s)are noncanonical four-stranded DNA structures formed by Hoogsteen base paring between stacked sets of......
Association of leukocyte telomere length with non-alcoholic fatty liver disease in patients with typ
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The use of tree shrews as experimental animals for biomedical research is a new practice.Several recent studies suggest ......
Recent studies have demonstrated that many biological important processes are related to the conformation and assemb......
Specifically targeting human telomeric dimeric G-quadruplexes by polyehter-tethered di-berberine der
The design and synthesis of binders specifically multiple G-quadruplex units in the 3-terminal overhang of human tel......
Mammalian shelterin proteins POT1 and TPP1 form a stable heterodimer that protects chromosome ends and regulates tel......
目的研究自身免疫性甲状腺疾病(ATD)患者外周血淋巴细胞端粒长度的变化. 方法用流式原位杂交法检测38例ATD患者和48例健康对照者外......
The changes in telomerase activity and telomere length in HeLa cells undergoing apop-tosis induced b
The changes in telomerase activity and telomere length during apoptosis in HeLa cells as induced by sodium butyrate (SB)......
Using Electron Spectroscopic Imaging (ESI), we visualized the in situ binding of nucleic acids to nuclear matrix and 3H-......
A consistent association has been observed between leukocyte telomere length(LTL)and atherosclerosis,but the mechanisms ......
G-quadruplexes(G4s) play important roles in biological systems, such as telomere maintenance,replication, and transcript......
Electrochemical analysis of single molecules is a method with the strong ability of the enhanced efficiency and ultra-se......
Objective To summarize clinical and genetic features of childhood dyskeratosis congenital(DC)patients with bone marrow f......
MNS16A,a variable number of tandem repeats polymorphism in the TERT gene,has been suggested to regulate telomerase activ......
Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to in
Telomere shortening and mitochondrial dysfunction are closely linked with the degenerative pathogenesis in humans.Revers......
Total genomic DNA was extracted from leaves of Ginkgo biloba L. by the method of hot CTAB. After determining quantifica......
白细胞端粒长度(leucocyte telomere length,LTL)是衰老的生物标志物,较短的LTL与不良的心血管预后相关。端粒再生能力降低可能是......
AIM:To study the inhibitory effect of all-trans retinoic acidon human hepatocellular carcinoma cell line SMMC-7721and t......
According to the telomere repeated sequences of rice, two primers: (TTTAGGG) 3 and (CCCTAAA) 3CCC were used to amplif......
期刊
Telomerase is a ribonucleoprotein that directs the synthesis of telomeric sequence.It is detected in majority of malign......
端粒酶催化端粒延长能维持染色体组的完整性,是肿瘤发生的重要生物学标志.端粒酶反转录酶(TERT)是端粒酶中的催化亚单位,其活性在......
Clinical significance of telomerase and its associate genes expression in the maintenance of telomer
AIM: To observe the interaction between the expression of telomerase activity (TA) and its associate genes in regulation......
1 IntroductionTelomeresarespecializedstrucuresattheendsofchromosomesandareimportantinprotectingandstabilizingthechromos......
与传统的解剖学、细胞学方法不同,分子生物学早期诊治肿瘤的关键在于找到一种肿瘤细胞生长所必须的、而正常细胞内又不存在的特殊......
自从1994年Counter等在卵巢痼的转移腹水中检测到了端粒酶(telomerase)的活性表达,并同时证实这种活性并不存在于正常卵巢上皮组......
Objective: To express human telomeric repeat binding factor (TRF1) at high level in E. coli. Method: Two primers were d......
Many anti cancer drugs have been found to trigger apoptosis in tumor cells through the production of reactive oxygen ......
AIM:To study the effects of doxorubicin on telomeraseactivity and telomere length in hepatocellular carcinoma.METHODS:T......
Ataxia telangiectasia (AT) is a rare human disease characterized by extreme cellular sensitivity to radiation and a pre......
AIN:To search for the biomarker of cellular immortalization,the telomere length,telomerase activity and its subunits in......
Chromosome behavior in meiosis was studied by ail-drying, C-banding and surface-spreading methods in female intersexes o......
Human chromosomes terminate with severalkilobases of the simple telomere repeat (TTAGGG) n.Telomeres protect the chromo......
多细胞生物个体的衰老是由于体细胞的有限分裂次数所造成。是什么原因导致体细胞在分裂一定次数后停止分裂?最近关于这方面的研究......
端粒和端粒酶对于细胞生存和肿瘤发生具有非常重要的意义 ,端粒酶各个组分的结构、功能及其调控已成为肿瘤学的研究热点。端粒酶的......
We’ve been taught that exercise at any age is beneficial to good health and longevity,but recent research has zoomed in......
Clinical significance of telomerase and its associate genes expression in the maintenance of telomer
AIM: To observe the interaction between the expression of telomerase activity (TA) and its associate genes in regulation......
Objective: To investigate the relationship between telomere length and radiosensitivity in various human cancer cell lin......
