The mechanism behind the aberrant expression of S100A6 in osteosarcoma is seldom reported so far.This study sought to ex......

目的:探讨CT和磁共振成像(MRI)诊断成人骨肉瘤的临床价值。方法:回顾性纳入2015年1月至2019年12月郑州市骨科医院收治的临床确诊为......

The occurrence of osteosarcoma is related to a variety of oncogenes and tumor suppressor genes. DNA methylation is an im......

Osteosarcoma (OS),the most common malignant bone tumor with high metastatic potential,frequently affects children and ad......

Photodynamic therapy (PDT),which is a new method for treating tumors,has been used in the treatment of cancer.In-depth r......

Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine (CHM) on tumor volume an......

Osteosarcoma is a rare primary malignancy of bone that is prone to early metastasis.Resection surgery and chemotherapeut......

Multidrug resistance (MDR) is one of the major obstacles in cancer chemotherapy.Our previous study has shown that icarii......

Background: In the head and neck region, osteosarcoma is the most common primary malignant bone tumor.However, osteosarc......

Purpose:Osteosarcoma is the most common primary bone malignant tumor with an extraordinary poor prognosis.And early pulm......

Background:joint-salvage surgery for patients with juxta-articularosteosarcoma remains challenging,especially when tumor......

Recent advances highlighted profound roles of FOXO transcription factors especially FOXO1 in bone development and remode......

Recent studies have shown that WW domain containing E3ubiquitin protein ligase 1(WWP1)is frequently amplified in various......

Purpose:A nalyze protein and gene expression of mGluRs (mGluR1, mGluR5, mGluR4) in osteosarcoma tissues and discuss the ......

The role of autophagy in tumor seems to be complex, with reports indicating both pro-tumor and anti-tumour roles.Here th......

Osteosarcoma is the most common primary osseous malignancy.The p53 mutation is a common genetic alteration in osteosarco......

Osteosarcoma resection is challenging due to the variable location of tumors and their proximity with surrounding tissue......

Epidermal growth factor-like domain 7 gene(EGFL7)encodes an angiogenesis related factor and plays a crucial role in many......

OBJECTIVE: To explore the function of activating transcription factor 4(ATF4)and the factors that modulate ATF4 activity......

目的：筛选骨肉瘤化疗耐药患者中差异表达的miRNAs,重点确定调控TWIST表达和骨肉瘤化疗耐药的miRNA.方法：1.miRNA芯片筛选骨肉瘤化疗......

Osteosarcoma cells utilize their intrinsic migratory ability to invade adjacent tissues and the vasculature, and ultimat......

Background We tried to determine whether intra-epiphyseal resection for epiphysis preservation could lead to limb discre......

Osteosarcoma(OS) is the most common primary malignant bone tumor. The survival rate of OS patients remains at 55-75 % du......

Introduction To perform a metaanalysis for comparing the functional outcomes and quality of life(QOL)of osteosarcoma pat......

The aim of the present study was to evaluate the influence of polymorphisms in NER and HRR pathways on the response to c......

Osteosarcoma is the most common primary bone cancer affecting children and adolescents, notorious for its pulmonary meta......

Purpose: Immune escaping and chemoresistance of tumor cells constitute two major key barriers to the successful manageme......

Background:The cationic porphyrin TMPyP4, a widely used G-quadruplex ligand, was reported to inhibit the growth of osteo......

MicroRNAs(miRNAs)are classes of small noncoding RNA molecules that play important roles in regulating the expression of ......

Background: Osteosarcoma (OS) is the most commonly bone malignant tumor, which is considered a differentiation disease. ......

Background:Osteosarcomas are sarcomas of the bone with a high propensity to metastasize. Ezrin is a member of the ezrin-......

Limb shortening is a problem associated with surgery for osteosarcoma of the lower extremity in adolescents, as the tumo......

TheWntsignalingpathwayregulatessomeofthecrucialaspectsofcellularprocesses.Thebeta-catenindependentWntsignaling(Wnt/β-ca......

Objective.The aim of this study was to evaluate the relationship between glutathione Stransferase p1(GSTP1)polymorphisms......

目的 检测Bim蛋白在3种骨肉瘤细胞中和1种正常成骨细胞中的表达.方法 提取成骨肉瘤细胞Saos-2和成骨细胞hFOB 1.19中总RNA,通过全......

Objectives: Growing evidence shows that SLC3A2(Solute carrier family 3 member 2)is upregulated and involved in tumor gro......

Objectives: Increasing evidences demonstrates that XRCC6 was upregulated and involved in tumor growth in several tumor t......

Thereismountingevidencethatmetastasis-associatedincoloncancer-1(MACC1)playspivotalrolesin developmentandprogressionofman......

Embelin is an active compound identified as a novel XIAP inhibitor from the Embelia ribes that exhibits various medicina......

Growing evidence has suggested that inhibitor of growth 4(ING4),a novel member of ING family proteins,plays a critical r......

Osteosarcoma is the most common cancer in bone,mainly arising from the metaphysis of the long bones.MicroRNA(miR)-200b h......

Osteosarcoma(OS)is the most common cancers in bone.Chemotherapy is commonly used for the clinical treatment of OS....

Here,forthefirsttime,Ag2Snanoparticlesareinvestigatedasphotothermaltransducingagentsonosteosarcoma treatment.TheAg2Swate......

Objective Osteosarcoma is the most common primitive malignant tumor of the skeletal system and is characterized by an ag......

Background:LivinandPlGF(placentalgrowthfactor)arenotdetectableinmostnormaldifferentiated tissuesbutarepresentinseveralca......

Osteosarcoma(OS)is the most common primary malignancy of bone and is usually associated with poor prognosis due to its h......

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Objective:To study the impacts of tumor location, nature and extent of bone destruction on selection of operative protoc......

Objective To explore the expression of 14-3-3β in osteoscarcoma cells,and to investigate the effects of 14-3-3β on the......

Background:TheexpressionofSrcandphospho-Src(p-Src),iscloselyrelatedtotumorinvasionandmetastasis....