PROTEASOME相关论文
Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile men.Spermat......
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Largemouth Bass Micropterus salmoides is an economically important freshwater fish cultured in China.The new emerging vi......
BDNF-TrkB signaling mediates ubiquitin-proteasome-dependent homeostatic regulation of synaptic prote
Homeostatic regulation of synaptic properties in response to chronic alteration of neuronal activity is essential for ne......
Despite the fundamental importance of proteasomal degradation in cells,little is known about whether and how the 26S pro......
The ubiquitin-proteasome degradation pathway plays an essential role in multiple cellular processes, including cell cycl......
Overexpression of Sphingosine Kinase 2 Antagonizes the Effect of All-Trans Retinoic Acid (ATRA) in a
All-trans retinoic acid (ATRA) is a promising therapeutic agent, but exhibits low efficacy against human cancers.Sphingo......
Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasom
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Pluripotent stem cells (PSCs) can be expanded in vitro in different culture conditions, resulting in a spectrum of cell ......
Efficacy of Qingre Huayu Fang (清热化瘀方) on atherosclerotic vulnerable plaque in apolipoprotein E knock
OBJECTIVE: To investigate the efficacy and mechanism of the Qingre Huayu Fang(清热化瘀方) on atherosclerotic vulnerable ......
Barley NLR Receptor Triggers Immunity by Derepressing Defense Transcriptions through Acetylation and
Plant employs NLR receptors to recognize isolate-specific effectors and induce massive transcriptional reprogramming......
Phosphorylation of Serine 158 in Proteasome 1 Subunit Regulates Its Conversion From Proteasomal Asse
p27kip1 is one of the key factors controlling cell cycle.The intracellular level of p27kip1 is mainly regulated by the u......
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Vitamin E protects PC12 cells against manganese-induced cytotoxicitythe role of oxidative stress and
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The proteasome inhibitor VELCADE induces protein markers of endoplasmic reticulum stress and hypoxic
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2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 s
AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was in......
Triphenyltin (TPT ) 广泛地向神经房间和相关机制遗体作为环境污染物质，而是它的毒性存在不清楚。在这研究， SHSY-5Y 房间暴露于 TP......
【目的】 研究分析编码蛋白酶体调控复合物亚基基因BmRpt4(Regulatory particle triple-A ATPase4,BGIBMGA010794)在家蚕翅膀发育......
In the MHC classⅠmolecule binding antigenic peptides processing and presentation pathway,the ubiquitin-proteasome syste......
Proteins that are modified by a small ubiquitin to form ubiquitin chains are dedicated to proteasomes for degradation.Mo......
当硼替佐米和卡非佐米被FDA批准用于治疗多发性骨髓瘤后,20S蛋白酶体已经作为靶点引起了关注,但这两种药物存在耐药性。作为第二代......
目的探讨蛋白酶体抑制剂MG132对He La细胞增殖的影响。方法用不同浓度的蛋白酶体抑制剂MG132(1、3、5、8和10μmol/L)处理He La细......
Objectives To administrated proteasome inhibitor-MG-132 prior to reperfusion in rat myocardial ischemia-reperfusion mode......
AIM: To investigate the mechanism of calcyclin binding protein/Siah-1 interacting protein(Cacy BP/SIP) nuclear transloca......
Objectives To test the hypotheses that bone morphogenetic protein(BMP) signaling pathway components are expressed in art......
Multiple myeloma remains incurable with conventional treatments.However,new active drugs,including the immunomodulatory ......
Ablation of adenosine monophosphate-activated protein kinase α1 in vascular smooth muscle cells prom
AIM: Atherosclerotic calcification is highly linked with plaque instability and cardiovascular events. Adenosine monopho......
TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS g
OBJECTIVE The Ca2+-activated Cl-channel(Ca CC)plays a crucial role in various physiological functions.Recent evidences s......
Objective: To compare gene expression profiles of nasopharyngeal carcinoma (NPC) tissue with that of control tissue by c......
Though there were a lot of reports about the totally different responses to the inhibition of ubiquitin-proteasome path......
Objective: A single mechanistic pathway cannot explain the genesis of drug resistance in cancer. Drug resistance in canc......
AIM:To investigate and determine the mechanism and signalpathway of tetradecanoylphorbol-1,3-acetate(TPA)indegradation ......
AIM:To investigate the inhibitory effect of ubiquitin-proteasome pathway(UPP)on proliferation of esophagealcarcinoma ce......
Protein degradation through the ubiquitin-proteasome system is the major pathway of non-lysosomal proteolysis of intrace......
Proteasome alteration and delayed neuronal death in hippocampal CA1 and dentate gyrus regions follow
BACKGROUND:Proteasome dysfunction has been reported to induce abnormal protein aggregation and cell death.OBJECTIVE:To i......
Gel-Based Chemical Cross-Linking Analysis of 20S Proteasome Subunit-Subunit Interactions in Breast C
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L-Carnosine (β-alanyI-L-histidine) is a naturally occurring dipeptide,which has shown broad-spectrum anticancer activit......
Objective: To monitor the systemic gene expression profile in a murine model of lipopolysaccharide-induced acute lung i......
Objective To analyze the protein expression in the rat hippocampus by the proteomic approach. Methods Proteins from hipp......
Neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates th......
Parkinson’s disease (PD) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic ......
