phosphorylation相关论文
RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active ......
The pre-mRNA processing factor Prp6 is an essential component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP......
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Therefore, exploring the mechanism of CVDs an......
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Nitrate reductase (NR) is a key enzyme for nitrogen assimilation in plants, and its activity is regulated by posttransla......
含有C(sp3)—P键的有机磷化合物被广泛应用于有机合成、生物有机和药物化学、农药、阻燃剂和萃取剂等领域中.近年来,C—H键的直接......
Nitrate reductase (NR) is an important enzyme for nitrate assimilation in plants, and post-translational phosphorylation......
Persulfidation-induced structural change in SnRK2.6 establishes intramolecular interaction between p
Post-translational modifications (PTMs),including phosphorylation and persulfidation,regulate the activity of SNF1-RELAT......
NLRP3是位于细胞质中的模式识别受体,属于NOD样受体家族.在多种危险相关分子模式和病原体相关分子模式的激活下,NLRP3受体通过招募......
Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dement
Objective: To observe the effect of puerarin on methyl-CpG binding protein 2 (MeCP2) phosphorylation (pMeCP2) in the hip......
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behavior
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Glucose sensor MdHXK1 phosphorylates and stabilizes MdbHLH3 to promote anthocyanin biosynthesis in a
Glucose induces anthocyanin accumulation in many plant species;however, the molecular mechanism involved in this process......
The anti-adipogenic effect of PGRN on porcine preadipocytes involves ERK1,2 mediated PPARγ phosphory
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Osteosarcoma is the most common primary osseous malignancy.The p53 mutation is a common genetic alteration in osteosarco......
O-GlcNAc glycosylation of p27kip1 promotes formation of glial scar and functional recovery after spi
Objective:To study the effect of O-GlcNAc glycosylation of p27kip1 on spinal cord injury, and provide further evidence f......
Osteosarcoma is the most common primary osseous malignancy.The p53 mutation is a common genetic alteration in osteosarco......
GSK-3inhibition suppresses lung cancer cell survival,metastasis andproliferation through down-regula
目的 Our Previous studies showed that CAP1 was associated with advanced TNM stage and poor prognosis of lung cancerpatie......
Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and pred
Objective Hepatocellular carcinoma(HCC)is one of the most common malignancies and one of the most frequent causes of can......
The effect of phosphorylation sites-directed mutagenesis of osteopontin on proliferation,apoptosis a
Objective: The aim of this study is to observe the effect of phosphorylation sites-directed mutagenesis of OPN on prolif......
Objective.The enteric nervous system(ENS)control the function of gastrointestinal tract,such as gastrointestinal motilit......
Reversal of decreased hippocampal protein serine/threonine kinases by modulating pineal hormone in a
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Converging lines of evidence demonstrate that intracellular accumulation of α-synuclein(α-Syn)as filamentous aggregate......
Protopanaxadiol ginsenoside-Rd protects against NMDA receptor-mediated neuronal injury by inhibiting
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The disturbance of hippocampal CaMKII/PKA/PKC phosphorylation in early experimental diabetes mellitu
Aim: To studyhowhippocampalserine/threonine kinases signaling changes inthe early phase of diabetic rats (both type 1 an......
Neurofilament light subunit (NFL) is the core component of neurofilaments, which are the main intermediate filaments (IF......
Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-acti
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GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signal
Epithelial-mesenchymal transition (EMT) is a key process in tumor metastatic cascade that is characterized by the loss o......
Chronic pain after surgery is a serious issue in clinical practice that has received increased interest in recent years.......
Internalization and sorting of agonist-stimulated receptors between divergent recycling and degradative membrane pathway......
STAT3 acetylation is necessary for antiogensin Ⅱ-induced STAT3 phosphorylation and extracellular mat
The nuclear transcription factor signal transducer and activator of transcription 3 (STAT3) plays a significant role in ......
Protein phosphorylation of FLA8/KIF3B serves as a molecular switch to control IFT entry and turnarou
Intraflagellar transport (IFT), a bidirectional transport system between the ciliary base and tip, delivers ciliary prec......
MicroRNAs(miRNAs)affect cancer cell glucose metabolism by targeting mRNAs of diverse enzymes that have been implicated i......
Despite the fundamental importance of proteasomal degradation in cells,little is known about whether and how the 26S pro......
Microglial DICER was phosphorylated at serine 1456 by c-jun N-terminal kinase(JNK)and downregulated in response to 1-met......
SAE1 promotes human glioma progression through activating AKT SUMOylation and AKT signaling pathways
The SUMO-activating enzyme SAE1 involves in progression of several human cancers.However,its biological roles of SAE1 in......
Phosphorylation is a major type of post-translational modification,which can influence the cellular physiological functi......
Intervertebral disk degeneration (IDD) is a major cause of low back pain, an important socioeconomic burden.Extracellula......
Influence of estrogen receptor α phosphorylation at serine 309 on male reproductive function of mice
Recent studies in estrogen receptor α(ERα)knockout mice have demonstrated that the testicle development is abnormal,an......
The endosomal sorting complex required for transport(ESCRT)machinery is an ancient system that mainly controls multivesi......
Role of phosphorylation at Serine 1439 in subcellular localization and function of L-periaxin in Sch
L-periaxin is an important scaffold protein in nerve cells of mammals.During the development and maturation of Schwann c......
Role of FADD phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiolo
Fas-associated death domain-containing protein (FADD),a classical apoptotic signaling adaptor,also takes part in many no......
Previously,we found that the activation of protein kinase C delta (PKCδ) upon apoptosis inducers resulted in enhanced p......
Hsp90 participates in the 20-hydroxyecdysone and the juvenile hormone signaling pathways by the vari
Background: Hsp90 is vitally important among the various HSPs because its target proteins are always steroid hormone rec......
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Objective.Synapse formation is crucial for learning and memory.Understanding the underlying molecular mechanisms of syna......
Gap junctions(GJ)play an important role in intercellular communication between adjacent cells.The protein expression,mem......
Chronic myeloid leukemia (CML), an acquired malignant myeloproliferative disorder of hematopoietic stem cells, is one of......
