Shikonin相关论文
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrop
Hypertrophic scars are unfavorable skin diseases characterized by excessive collagen depo-sition.Although systemic treat......
Electrochemical Study and Application on Shikonin at Poly(diallyldimethylammonium chloride) Function
The electrochemical behaviors of shikonin at a poly(diallyldimethylammonium chloride) functionalized graphene sheets mod......
Shikonin and its derivatives are secondary metabolites of naphthoquinones with significant anti-inflammatory,antitumor,a......
Overexpression of LeMYB1 enhances Shikonin Formation by Regulating Shikonin-biosynthesis Related Gen
Shikonin and its derivatives are a class of naphthoquinone pigments synthesized in Boraginaceae plants,such as Lithosper......
Novel anti-tumor efficacy of a target peptide combined mPEG-P encapsulated shikonin against osteosar
Osteosarcoma is the most common primary bone cancer affecting children and adolescents, notorious for its pulmonary meta......
Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastri
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Shikonin time-dependently inhibits the migration and invasion capacity of gastric cancer cells via g
Objective Neoplasms of stomach are killers that threaten the life and health of the residents of our country,of which th......
Transcriptom analysis reveals that blocking the ethylene signal transduction pathway is one key poin
The plant growth regulator 2,4-Dichlorophenoxyacetic acid(2,4-D)significantly inhibits the biosynthesis of shikonin and ......
Endogenous jasmonate is the key regulator of the two-stage culture system(TSCS)-induced shikonin bio
The phytohormone Jasmonates(JAs)play crucial roles in multiple plant physiological processes,including secondary metabol......
Transgenic analysis reveals LeEIL-1 as a positive regulator of shikonin biosynthesis in Lithospermum
The phytohormone ethylene(ET)plays an important role in regulating the biosynthesis of shikonin and its derivatives,whic......
LeMYC is a novel member of the basic helix-loop-helix (bHLH) family that was cloned from Lithospermum erythrorhizon by u......
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Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasom
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The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various hu......
目的：探讨紫草素(Sh)在人表皮共培养体系中对黑素转运的影响。方法采用MTT法测定紫草素对人黑素细胞（MC）与角质形成细胞（KC）共培养体系......
目的:研究紫草素对DNA拓扑异构酶I催化活性和K562白血病细胞凋亡的影响.方法:从K562白血病细胞提取拓扑异构酶I,通过DNA解螺旋试验......
目的:探讨紫草素对银屑病样动物模型Th17细胞相关因子的影响。方法:将6~8周龄雌性BALB/c小鼠随机分为空白对照组、低剂量紫草素组......
细胞凋亡(Apoptosis),又称为程序性细胞死亡(Programmed cell death),是指为维持内环境稳定,由基因控制的细胞自主的有序的死亡。......
,Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 nec
Necroptosis is a type of programmed necrosis regulated by receptor interacting protein kinase 1 (RIP1) and RIP3.Necropto......
,Shikonin attenuates hyperhomocysteinemia-induced CD4+ T cell inflammatory activation and atheroscle
T cell metabolic activation plays a crucial role in inflammation of atherosclerosis.Shikonin (SKN),a natural naphthoquin......
Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced
Background The role of extracellular signal-regulated kinase 1/2 (ERK1/2) in shikonin-induced HeLa cells apoptosis remai......
Shikonin Promotes Skin Cell Proliferation and Inhibits Nuclear Factor-κB Translocation via Proteasom
Background:Shikonin is a major active chemical component extracted from Lithospermi Radix,an effective traditional herb ......
目的研究紫草素对脂多糖诱导的新生大鼠急性肺损伤(ALI)的保护作用。方法 7d龄SD大鼠40只随机均分为四组,采用脂多糖5mg/kg腹腔注......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
程序性坏死是近年来发现的一种由死亡受体介导的 caspases 非依赖性细胞死亡模式，通常在凋亡被抑制的情况下发生，具有坏死细胞的形态......
Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced
Background The role of extracellular signal-regulated kinase 1/2 (ERK1/2) in shikonin-induced HeLa cells apoptosis remai......
A new approach for asymmetric synthesis of alkannin and shikonin is presented. The chiral centers of the targets were in......
在pH 7.4的Tris-HCl介质中,以盐酸小檗碱(BR)为荧光探针,研究了紫草素(SHI)与鲱鱼精DNA的相互作用。结果表明,SHI与BR竞争结合DNA......
目的:采用三氯乙酰亚胺酯法合成紫草素-1′-O-β-D-吡喃葡萄糖苷。方法:以β-D-吡喃葡萄糖为起始原料制得糖基供体2,3,4,6-四-O-乙......
目的探讨紫草素通过调控Hippo-YAP信号通路对咪喹莫特诱导的银屑病模型小鼠的影响及作用机制。方法将25只BALB/C雄性小鼠随机分为......
目的探究紫草素对肾透明细胞癌凋亡及抗失巢凋亡的作用及其机制。方法实验分为四组,对照组、紫草素低、中、高剂量组(1、2、4mg/mL......
目的:研究紫草素对人大肠癌HT29细胞奥沙利铂化疗增敏作用及其机制。方法:体外培养并取对数生长期人大肠癌HT29细胞,设紫草素(0.5 ......
将紫草细胞接种在添加０．２％表面活性剂Ｔｗｅｅｎ２０紫草素生产培养基中，并于２５℃黑暗条件下振荡培养，结果发现：表面活性剂Ｔｗｅｅｎ２０可明显提高细胞向胞外分泌紫草素......
目的建立蒙药拉哈如各贡斯勒散的定性鉴别及含量测定方法。方法采用TLC法对方中栀子苷进行定性鉴别。运用HPLC法对紫草中左旋紫草......
目的研究紫草素对三阴性乳腺癌细胞MDA-MB-231增殖的影响,并探讨其作用机制。方法配制不同浓度(0,2.5,5,7.5,10,15μmol/L)的紫草......
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic my
这研究检验了 shikonin 导致的发信号的事件在 Bcr/Abl-positive 导致 apoptosis 的正式就职长期的骨髓内产生的白血病(电流型逻辑......
Enhancement of Shikonin Production in Cell Suspension Cultures of Arnebia Euchroma Employing Two-Liq
1 INTRODUCTIONThe production of secondary metabolites using plant cells has been the subject of much inter-est in recent......
目的：研究用超声技术提取紫草素的方法。方法：采用超声波法和乙醇浸取法提取紫草素，测定溶液的吸光度值，并进行比较。结果：超声法提取在......
电化学伏安行为研究表明,在pH 3.98的HAc-NaAc（20%乙醇）缓冲溶液中,紫草素在玻碳电极产生了一对氧化还原波,并证实这一反应是受吸附......
[摘要]目的：研究紫草素对正常人表皮黑素细胞黑素合成的影响，及对紫外线辐射后黑素细胞黑素合成的影响。方法：用体外培养正常人表皮黑......
紫草素在0．2mol／LHAc-NaAe缓冲溶液（pH4．3）中，产生灵敏的线性扫描极谱峰，峰电位EP=-0．186V（us．Ag／AgCl）。峰电流与紫草素浓度在5×10-7～1......
目的：研究紫草素对人白血病细胞株K562增殖抑制和诱导凋亡作用。方法：四氮甲唑蓝（MTT）观察细胞的生长状况，应用彗星分析法、TUNEL技术和......
采用电化学测试方法测定了紫草素在玻碳电极上的电化学行为。结果表明,紫草素在玻碳电极产生一对氧化还原波,在pH为3.98及HAc-NaAc......
从四川密花滇紫草(Onosma confertum W.W.Smith)和新疆软紫草[Arnebia euchroma (Royle) Johust]的根中分到九个紫草素衍生物,其中......
目的植物细胞初生代谢是次生代谢的基础，与细胞的发育状态有关。从几个方面探讨细胞发育状态与色素形成能力的关系。方法研究了接种......
目的建立紫草软胶囊中左旋紫草素的含量测定方法。方法采用HPLC法，考证于不同流动相组合、流速及柱温等条件下测定紫草软胶囊中左旋......
