CYCLIN相关论文
33. The Study of Mechanism By Which The Telomerase Template Phosphorothioate Antisense Oligonucleoti
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目的:探讨人乳头瘤病毒（HPV）DNA联合外周血细胞周期蛋白A（cyclin A）、细胞周期蛋白依赖激酶2（CDK2）mRNA检测对子宫颈鳞状细胞癌的诊断价......
在细胞周期的调控过程中,有两大家族的蛋白发挥着重要的作用。一个家族是CDK,它们磷酸化特异的蛋白来调节下游通路。另一个家族是......
细胞周期蛋白（cyclin）和周期蛋白依赖性激酶（cyclin dependent kinase,CDK）是细胞周期信号通路中关键的调控因子,同时也是调节卵巢发育......
Cell cycle regulation that plays a pivotal role during organism growth and development is primarily driven by cyclin-dep......
Introduction: Cyclins/retinoblastoma protein(pRb)pathway participates in cardiomyocyte hypertrophy.Cyclins and cyclin ki......
Temporal expressions of cell cycle regulators mRNA during hypertrophic process of H9c2 cells induced
Aim: To observe the mRNA expressions of cell cycle regulators at different time point during the hypertrophic process of......
Temporal expressions of cell cycle regulators mRNA during hypertrophic process of H9c2 rat cardiomyo
Aim: To observe the mRNA expressions of cell cycle regulators at different time point during the hypertrophic process of......
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目的利用小于扰RNA（siRNA）抑制骨肉瘤及正常成纤维细胞中cychn A2基因的表达，并观察其对细胞生物活性的影响。方法设计并化学合成3对......
目的探讨circ_0001946对胃癌细胞恶性表型的影响及可能机制。方法采用qRT-PCR法检测胃癌组织和细胞系(HGC-27、AGS、MKN45)中circ_......
Cell Cycle Perturbations Induced by Human Herpesvirus 6 Infection and Their Effect on Virus Replicat
In eukaryotic cells, cell growth and division occur in a stepwise, orderly fashion described by a process known as t......
增殖细胞核抗原(Proliferating Cell NuclearAntigen,简称PCNA),又称Cyclin或DNA聚合酶δ辅助蛋白,是一个36KD的核内蛋白多肽。19......
Liuweiwuling tablets attenuate acetaminophen-induced acute liver injury and promote liver regenerati
AIM: To explore the mechanism of protection against acetaminophen-induced acute liver injury by Liuweiwuling tablets.MET......
细胞生长周期是由一系列细胞内在的蛋白来调控,这些蛋白包括细胞周期素、细胞周期素依赖的蛋白激酶和蛋白激酶抑制因子。本文综述......
Meiotic bouquet formation(known as crescent formation in Tetrahymena thermophila) is indispensable for homologous pairin......
目的 探讨卵巢上皮性肿瘤 Cyclin D1 ,p Rb的表达水平与其良恶性的关系 .方法 卵巢上皮性肿瘤石蜡切片Cyclin D1 ,p Rb抗体免疫......
目的 探讨抑癌基因 p16及细胞周期素 D1 (CyclinD1 )在子宫内膜癌、交界性子宫内膜组织及正常子宫内膜组织中的表达规律及其与子......
目的:探讨健脾化瘀方基于PI3K/Akt通路抑制大肠癌SW480增殖的相关机制。方法:取对数生长期的SW480细胞,噻唑蓝(MTT)检测不同质量浓......
目的:了解莪黄汤含药血清对人结肠癌SW480细胞增殖的影响及对Wnt/β-catenin信号通路中β-catenin、cyclin D1蛋白表达的影响。方......
目的研究猪苓多糖(polyporus polysaccharide,PPS)抑制肺癌A549细胞增殖的作用及其机制。方法设对照组和PPS低、中、高剂量组,用MT......
Different Patterns of Cyclin D1/CDK4-E2F-1/4 Pathways in Human Embryo Lung Fibroblasts Treated by Be
Objective To investigate the roles of the cyclin D1/CDK4 and E2F-1/4 pathways and compare their work patterns in cell cy......
目的:探讨苏木含药血清对人肺癌PG细胞株的增殖抑制作用及对Cyclin D1、CDK4蛋白表达的影响。方法:将肺癌PG细胞分为空白组、苏木......
近年来 ,越来越多的学者注意到细胞增殖周期的失调在肿瘤的发生中所起的关键作用 ,特别是 G1期的启动和失调与肿瘤的发生、发展密......
滑膜衬里层增厚是类风湿关节炎（ｒｈｅｕｍａｔｏｉｄａｒｔｈｒｉｔｉｓ，ＲＡ）的重要病理学特征之一，但机制不清。本研究用核酸分子原位杂交技术检测反映细胞增殖状况的细胞周期蛋......
目的 研究维生素D受体 (VDR)在继发性甲旁亢 (SHPT)患者甲状旁腺 (PT)中的表达 ,探讨严重继发性甲旁亢患者对钙三醇抵抗的机制以......
目的:探讨Cyclin D1和CDK4在正常宫颈上皮、CIN和宫颈鳞癌中表达状况。方法:收集子宫颈活检及手术标本118例,其中正常鳞状上皮14例......
Changes of Protein Kinase Cα and Cyclin D1 Expressions in Pulmonary Arteries from Smokers with and w
The purpose of this study was to investigate the changes of protein kinase Cα(PKCα) and cyclin D1 expressions in pulmo......
目的:探讨染料木素对人卵巢癌裸鼠皮下移植瘤的抑制作用及其机制。方法:建立人卵巢癌裸鼠皮下移植瘤模型,通过腹腔注射的给药方式......
褐藻糖胶有多种生物学活性和保健功能,其中抗肿瘤活性尤为突出。在此通过系统的文献检索和总结,对褐藻糖胶的抗肿瘤活性及可能机制......
AIM: To investigate the mechanism of calcyclin binding protein/Siah-1 interacting protein(Cacy BP/SIP) nuclear transloca......
The Gd-Co-Mn alloys with compositions of Gd33.3Co66.7,Gd33.3Mn66.7,Gd22.2Co74.8Mn3 and Gd25Co70Mn5 were prepared and exa......
目的观察Wnt/β-catenin通路抑制剂Wnt-C59对病理性心肌肥大的作用并探讨这一过程的分子机制。方法 (1)动物实验:对8~10周龄(18~22......
细胞周期的调控异常与细胞癌变密切相关,细胞周期蛋白(Cyclin)及其依赖性激酶(CDKs)形成的复合物是细胞周期的核心调控装置。Cycli......
目的 探讨肺癌中粘附分子CD44和癌基因cyclinD 1的表达意义。方法 应用S P免疫组织化学方法研究 6 2例肺癌组织中CD 44和cyclinD......
Effect of cis-9,trans-11-conjugated linoleic acid on cell cycle of gastric adenocarcinoma cell line(
AIM:To determine the effect of cis-9,trans-11-conjugatedlinoleic acid(c9,t11-CLA)on the cell cycle of gastric cancercel......
EFFECT OF CIS-9, TRANS-11-CONJUGATED LINOLEIC ACID ON CELL CYCLE OF MAMMARY ADENOCARCINOMA CELLS(MCF
Objective: To determine the effect of cis-9, trans-1 1-conjugated linoleic acid on the cell cycle of mammary cancer cell......
为探讨NADH对PC12细胞化学药物损伤后的修复作用 ,采用细胞实验检测NADH对顺铂、阿霉素、鱼藤酮对肾上腺髓质嗜铬细胞瘤PC12细胞系......
目的 CyclinD和CyclinE的异常表达常引起细胞周期调节异常而导致肿瘤。为阐明这些Cyclin基因在人体胃癌发生、发展过程中的作用 ,......
AIM:To investigate the global gene expression of cancerrelated genes in hepatoma cell line HLE using Atlas HumanCancer ......
Effects of Cyclin D1 Antisense Oligodeoxyneucleotides on the Growth and Expression of G_1 Phase Regu
To investigate the effects of Cyclin D1 antisense oligodeoxyneucleotides (ASODN) on the growth, cell cycle progression a......
选择性增殖腺病毒dl1520是一种新型的进入III期临床研究的肿瘤病毒基因治疗药物,本文综述了dl1520的发现、结构、实验研究和作用机......
正常细胞通过内外因子的调节 ,有序地循着细胞周期 ,不断分裂增生与凋亡。一般胚胎细胞的增生速度大于凋亡速度 ,细胞增多 ,组织逐......
目的 研究三氧化二砷(As2O3)对人胃癌细胞株癌相关基因的影响,探讨其抗肿瘤作用。方法 以As2O3作用于体外培养的人胃癌细胞株,通过......
近年研究发现 ,细胞周期调控机制紊乱是细胞增生失控从而导致癌变的重要原因。哺乳动物中 ,一个典型的细胞周期由有严格顺序并循精......
