Oligonucleotide相关论文
33. The Study of Mechanism By Which The Telomerase Template Phosphorothioate Antisense Oligonucleoti
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因寡聚核苷酸优秀的生物相容性、多样的二级结构及与银离子的特殊相互作用使其成为合成银纳米簇模板中最具特色的一种。寡聚核苷酸......
Oligonucleotides are useful tools in chemical biology for biosensing and therapeutics.The well-known examples include fu......
In this paper, we have developed a label-free fluorescence method for sensitive detection of mercury ion in homogeneous ......
Study on radiation-induced lesions of DNAs by using fluorescence-and quenching-modified oligonucleot
DNA is the main target of ionizing radiation.When DNA is irradiated to ionizing radiations, it undergoes main chain ......
Detection of two pathogenic marine ciliates Ancistrum haliotis and A. crassum(Ciliophora: Scuticocil
The scuticociliatid ciliates Ancistrum haliotis and A.crassum are parasites that may cause high mortality in the culture......
A novel typography technique was developed to in situ synthesize oligonucleotide arrays on glass slide,which has the cel......
A new quantitative structure-retention relationship model for predicting chromatographic retention t
一条综合途径被建议预言 oligonucleotides 的色析法的保留时间基于量的结构保留关系(QSRR ) 当模特儿。首先， oligonucleotides 的......
Phosphorothioate oligonucleotide inhibits tissue factor expression in endothelial cells induced by b
Objective: To determine the effect of antiparallel phosphorothioate triplex-forming oligonucleotide (apsTFO),which was d......
Phosphorothioate oligonucleotide inhibits tissue factor expression in endothelial cells induced by b
Objective: To determine the effect of antiparallel phosphorothioate triplex-forming oligonucleotide (apsTFO),which was d......
目的:比较不同种类特定序列寡核苷酸(Oligonucleotide,ODN)对人骨髓间充质干细胞(human bone marrow mesenchymal stem cells,hBMS......
为了能有效地操纵特定基冈的功能,科学工作者用光作为触发剂来调节特定基因表达并取得了一些成果.光作为一种干净的外在开关而逐渐......
本文通过对荣华二采区10...
Aim: To develop an easy, fast, automated, and inexpensive method for constructing short-hairpin-RNA cassettes for RNAi s......
Combined transfection of Bcl-2 siRNA and miR-15a oligonucleotides enhanced methotrexate-induced apop
Objective: B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction ......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 探讨生存素(Survivin)反义寡核苷酸(ASODN)诱导人胃癌细胞SGC7901凋亡的作用.方法 设计合成特异性靶向Survivin的ASODN,将胃......
Recently,we reported that deoxyribo-oligonucleotides could induce single chained cationic surfactant aggregation to form......
人类基因组学研究已实现从结构基因组向后基因组的全面转变,现阶段致病基因的克隆实质上已不是传统意义上的基因克隆,而主要是致病......
Summary: Silencing ATM gene gave rise to enhanced apoptotic response to irradiation and irradiation-like chemotherapy ag......
目的初步研究限制性显示技术(RD-PCR)作为一种高密度长链寡核苷酸芯片样本标记方法对芯片杂交信号的影响.方法收集3个健康人外周血......
目的 探讨C-myc反义寡核苷酸(ASODN)对人胆管癌QBC939细胞增殖和侵袭力的影响.方法 合成C-mycASODN,并将其转染QBC939细胞;四甲基......
应用特殊设计的寡核苷酸链纠正点突变技术是20世纪90年代发展起来的一项新技术,在酵母菌、植物细胞、哺乳动物细胞等不同的生物材......
Objective: The aim of the research was to study whether microRNA-15a (miR-15a) oligonucleotide could inhibitcell growth ......
目的 探讨雾化吸入信号转导和转录活化因子1(STAT1)反义寡核苷酸(ASON)干预肺纤维化的最佳给药时机.方法 Wistar雌性大鼠25只随机......
Telomeres are protein-DNA complexes at the terminals of linear chromosomes, which protect chromosomal integrity and main......
DNA microarrays have been acknowledged to represent a promising approach for the detection of viral pathogens. However, ......
A novel typography technique was developed to in situ synthesize oligonucleotide arrays on glass slide, which has the ce......
A novel strategy for in situ maskless synthesis of biochips:Self-driving micro-fluid porous type pri
A novel maskless technique, self-driving micro-fluid porous type printing (SMPTP), was reported to in situ synthesize ol......
目的 探讨成年及幼年羊关节软骨对急性机械性损伤在分子水平的反应.方法 建立羊的不同发育阶段关节软骨组织机械性损伤体外模型,运......
目的：观察NF—κB圈套寡核苷酸（Decoy ODNs）对NF-κB活性的影响，进一步探讨其对人肝癌细胞HepG2凋亡的作用机制。方法：设计NF-κB圈套寡......
DNA(脱氧核糖核酸)荧光标示技术是分子生物学中的一项重要技术,普遍应用于DNA测序、寡核苷酸杂交、荧光PCR等领域.本文综述了二十......
目的 观察CpG寡脱氧核苷酶（ODN）对2型糖尿病（T2DM）患者外周血单个核细胞（PBMC）γ干扰素（IFN-γ）、白细胞介素（IL）-12以及IL-10表达的影响。方......
目的探讨生存素（Survivin）反义寡核苷酸（ASODN）诱导人胃癌细胞SGC7901凋亡的作用。方法设计合成特异性靶向Survivin的ASODN，将胃癌细胞......
目的观察TGF-β1反义寡核苷酸(antioligodeoxynucleotide,antiODN)对高糖下肾小球系膜细胞分泌MMP-9、TGF-β1、collⅣ的影响.方法......
目的对双层脂膜（Bilayer lipid membranes，BLMs）在膜片电极上的构建和十二烷基修饰的寡核苷酸（Oligonucleotide）探针在BLMs上的固定技术......
The study of miR-15a oligonucleotide inhibiting cell growth and enhancing Ara-C-induced apoptosis in
研究的目的是学习 microRNA-15a (miR-15a ) oligonucleotide 是否能禁止房间生长并且提高 cytarabine (Ara-C ) 的目的在 Raji 房......
为了进一步阐明抗癌药与DNA结合的序列选择性和结合本质，用电喷雾质谱方法研究了抗癌药与DNA的相互作用，这些药物包括小沟结合剂（偏端......
制备了５‘端共价连接ＥＤＴＡ的寡聚苷酸与生命金属的螯合物ＯＤＮ－５’－ＥＤＴＡ．Ｍ（ｎ），其中Ｍ（ｎ）为Ｆｅ（Ⅱ）或Ｃｕ（Ⅱ）；分析、计算了这３个螯合物形成的最佳ＰＨ值范围，ＯＤＮ－ＥＤＴＡ．Ｆｅ（Ⅱ）为ＰＨ５．８－８．６，ＯＤＮ－ＥＤＴＡ，Ｃｏ（Ⅱ）为ＰＨ４．６－８．１，ＯＤＮ－ＥＤＴＡ，Ｃｕ（Ⅱ）为Ｈ３．４－５．７，在此条件一......
【正】BACKGROUND: Hypoxic preconditioning can protect hepatocytes against hypoxic injury, but its mechanism has not been......
目的:探讨白细胞介素-6(IL-6)反义寡核苷酸脂质体预防后发性白内障的可行性和有效性. 方法:30只健康新西兰大白兔随机分为三组,每......
目的探讨乙酰肝素酶反义寡核苷酸（ASODN）对人恶性黑素瘤裸鼠皮下移植瘤的抑制作用。方法分空白组、无关序列（N-ODN）组、10μmoL／LASODN......
寡核苷酸指导的基因修复是近几年发展起来的改造生物体遗传物质的技术。为了深入研究玉米细胞抽提物在寡核苷酸指导基因修复的体外......
研究探讨了一种基于活版印刷原理的中、低密度寡核苷酸微阵列原位合成新方法，该方法完全避免了掩模制备过程，合成速度快、制备成本低......
目的 研究端粒酶反义寡核苷酸对胶质瘤细胞端粒酶活性、细胞增殖和细胞凋亡的影响，为以端粒酶为靶点治疗脑胶质瘤提供理论和实验依......
目的构建高滴度大鼠Hesl腺病毒干扰载体（Ad—Hesl—shRNA）。方法设计3对Hesl—shRNA寡核苷酸序列，通过定向克隆构建pHBAd—U6-CMV-Hes......
DNA芯片技术的出现使基因鉴定变得快速、高效,为基因图谱研究、变异分析、基因定型及基因表达水平监测等提供了有力的工具.本文阐......
集中使用寡核苷酸、肽核酸和细胞凝素3类探针对来自东海和厦门海域的现场赤潮样品进行了检测，尝试鉴定识别自然水样中有害的赤潮原......
【目的】研究和确定芝麻ND-FISH最优试验条件，并对其在芝麻染色体识别中的可行性进行探索。【方法】以寡聚核苷酸（AC）8为探针，研究不同......
目的 检测针对组织因子（TF）基因启动子区切应力反应元件（shear stress response element，SSRE）设计的反向硫代形成三链DNA的寡核苷酸（ant......
