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一、静脉滴注胰岛素-葡萄糖-氯化钾溶液对低温犬心室的自发性颤动有非常显著的防止作用。对照犬极大部分(6/7)发生颤动,而试验犬则无颤动发生,全部终止于心室停搏。二、降滥过程中滴注胰岛素-葡萄糖-氯化钾犬的心电图变化(如QRS综合波增宽、T波降低及J波出现等)均较对照动物为小,表示对心室的去极和复极过程均有明显的保护作用。三、低温时滴注胰岛素-葡萄糖-氯化钾可使心室的舒张期兴奋阈显著提高,绝对不应期显著延长,而其传导时间并无明显改变。四、胰岛素-葡萄糖-氯化钾可能是由于使低温心室的不应期延长大于传导时间的延长,亦即使“传导时间/不应时间”的比率缩小,以致不利于兴奋的折返和颤动的发生而收抗颤的效果。实验结果进一步证明低温心室颤动的发生机制符合于环形运动学说。
First, intravenous infusion of insulin - glucose - potassium chloride solution on the canine ventricular fibrillation of spontaneous tremor has a very significant role in preventing. Control dogs most (6/7) tremor, while the test dogs did not occur fibrillation, all stopped in the ventricular arrest. Second, the process of abortion drip Insulin - glucose - potassium chloride changes in dogs (such as QRS comprehensive wave broadening, T wave and J waves appear to occur) are smaller than the control animals, said the ventricular depolarization and Repolarization process have obvious protective effect. Third, low-temperature infusion of insulin - glucose - potassium chloride can make the ventricular diastolic excitement threshold significantly increased, the absolute refractory period was significantly prolonged, and its conduction time did not change significantly. Fourth, insulin - glucose - potassium chloride may be due to prolonging the refractory period of the low-temperature ventricular in longer than the conduction time, and even if the ratio of “conduction time / non-responding time” is reduced so as to be detrimental to the occurrence of excited reentry and fibrillation And received anti-tremor effect. The experimental results further prove that the mechanism of hypothermia ventricular fibrillation in line with the theory of circular motion.