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裸鼠有很多T 细胞,但因为无胸腺,故不能产生病原体特异性T 细胞应答;重症联合免疫缺陷(SCID)小鼠由于不能重排和表达TCR 及Ig 基因而缺乏功能性淋巴细胞;给SCID H-2~d 小鼠静脉注射裸鼠(H-2~b)骨髓细胞,以弥补此二类小鼠上述不同
Nude mice had many T cells, but no pathogen-specific T cell responses due to absence of thymus; severe combined immunodeficiency (SCID) mice lacked functional lymphocytes due to inability to rearrange and express TCR and Ig genes; H-2 ~ d mice were injected intravenously with nude mice (H-2 ~ b) bone marrow cells to make up for these two different types of mice