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环氧化酶（ cyclooxygenase， COX）是前列腺素（ PGs）合成过程中的限速酶，它将花生四烯酸代谢成各种前列腺素产物，后者参与维持机体的各种生理和病理功能 [1]。 COX是膜结合蛋白，存在于核膜和微粒体膜 [2]。目前发现哺乳动物的 COX至少有 2个同工酶，即 COX- 1和 COX- 2。
Cyclooxygenase (COX) is the rate-limiting enzyme in the synthesis of prostaglandins (PGs). It metabolizes arachidonic acid into a variety of prostaglandin products, which are involved in maintaining various physiological and pathological functions of the body [ 1]. COX is a membrane-bound protein that is present in nuclear and microsomal membranes [2]. At present mammalian COX is found to have at least two isoenzymes, namely COX-1 and COX-2.