iPSCs相关论文
将已经分化的体细胞人工去分化生成多能性干细胞的方法称为诱导多功能干细胞（iPSCs）方法。其诱导过程经历了“体细胞的重编程”。应......
目的:血友病是由凝血因子缺失导致的一种X染色体隐性遗传的出血性疾病,目前血友病的治疗方法仍然是以输注凝血因子替代疗法为主,但......
A stable,rapid and effective neural differentiation method is essential for the clinical applications of human embryonic......
目的星形胶质细胞在神经系统疾病中的作用越来越被人们认识,脑内星形胶质细胞可以直接调节神经功能、生存和活动,调节神经细胞内外......
研究旨在探讨组蛋白赖氨酸去甲基化酶(JHDM2A)对猪成纤维细胞诱导为多能干细胞效率的影响,并对其内在的分子机制进行探究.以猪成纤......
目的 构建过表达生长分化因子5(GDF5)同时基因沉默锌离子转运蛋白(ZIP8)的双重功能慢病毒载体，检测其在诱导多能干细胞中的表达效率......
Pathogenesis and drug response of iPSC-derived cardiomyocytes from two Brugada syndrome patients wit
Brugada syndrome(BrS)is a complex genetic cardiac ion channel disease that causes a high predisposition to sudden cardia......
Induced pluripotent stem cells(iPSCs)resemble embryonic stem cells(ESCs)in morphology,gene expression and in vitro d......
Human Induced pluripotent stem cells (iPSCs) have pluripotency and self-renewal in common with embryonic stem cells ......
2006年,Yamanaka等人利用逆转录病毒将Oct4、Sox2、Klf4和c-Myc四个转录因子导入小鼠的成纤维细胞,成功获得了诱导多能干细胞（Induc......
背景脊髓小脑共济失调3型(Spinocerebellar Ataxia Type 3/SCA3)又称马查多-约瑟夫病(Machado-Joseph disease/MJD),是常染色体显......
背景:自诱导多能干细胞(iPSCs)技术建立以来,人们可以将已经分化的成体细胞重编程成具有与胚胎干细胞类似的多能性细胞。该技术为......
目的:研究生物钟基因Clock 对干细胞分化成熟过程的影响和机制.方法:我们将携带有Oct4、Sox2、c-Myc 和Klf4 的TetO-FUW-OSKM 慢病......
期刊
本文旨在研究小鼠诱导性多能干细胞(induced pluripotent stem cells,i PSCs)和骨髓间充质干细胞(bone marrow mesenchymal stem c......
自从2006年山中伸弥成功地将小鼠皮肤成纤维细胞重编程为诱导性多能干细胞(Induced pluripotent stem cells,i PSCs),i PSCs已成为......
,Ethanol inhibits histaminergic neurons in mouse tuberomammillary nucleus slices via potentiating GA
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Induced pluripotent stem cell (iPSC)-based cardiac regenerative medicine requires the efficient generation,structural so......
,Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatr
Cellular reprogramming allows for the de novo generation of human neurons and glial cells from patients with neurologica......
Mitochondrial diseases are mateally inherited heterogeneous disorders that are primarily caused by mitochondrial DNA (mt......
Neuropsychiatric disorders are complex disorders characterized by heterogeneous genetic variations,variable symptoms,and......
Induced pluripotent stem cells(iPSCs)resemble embryonic stem cells(ESCs)in morphology,gene expression and in vitro diffe......
The advent of induced pluripotent stem cells(iPSCs)has revolutionized the concept of cellular reprogramming and potentia......
诱导多能干细胞(induced pluripotent stem cells,i PSCs)是通过转录因子或者小分子化合物诱导体细胞形成的形态和功能类似于胚胎......
目的筛选并鉴定Alport综合征(AS)患者与健康对照者(NC)差异性表达蛋白质,寻找AS的生物标记物。方法收集AS组与NC组的尿液,从尿液中......
背景与目的 诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征......
葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症是由于G6PD基因突变引起的X连锁最常见的血液系统遗传疾病,目前的治疗以预防为主,严重者采用对症......
iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhan
这里，我们提供数据建议宫外的 reprogramming 因素的 silencing 的缺席使用了体的房间到改编到导致的 pluripotent 干细胞(iPSCs ) ......
目的：探讨盐酸克伦特罗对人类诱导多能干细胞（iPSC）来源心肌细胞的毒性作用。方法：将人皮肤来源的 iPSC 成功定向分化为心肌细胞,加入......
阿尔巴斯绒山羊多潜能干细胞（giPSCs）在遗传育种方面有重要的应用价值,然而目前还没有完善的giPSCs诱导及培养体系。为了获得稳定的g......
阿尔巴斯绒山羊多潜能干细胞（giPSCs）在遗传育种方面有重要的应用价值,然而目前还没有完善的giPSCs诱导及培养体系。为了获得稳定的g......
目的：探讨 Alport 综合征（AS）差异性表达蛋白质主要参与的 GO 富集分析和 KEGG 通路，为 AS 的进一步机制研究奠定基础。方法：10例 AS 患......
目的：探讨 Alport 综合征（AS）差异性表达蛋白质主要参与的 GO 富集分析和 KEGG 通路，为 AS 的进一步机制研究奠定基础。方法：10例 AS 患......
Reprogramming mouse ear mesenchymal stem cells (EMSC) expressing the Dlk1-Dio3 imprinted gene cluste
The identification of a single, early marker for full developmental potential of induced pluripotent stem (iPS) cells ha......
Reprogramming mouse ear mesenchymal stem cells (EMSC) expressing the Dlk1-Dio3 imprinted gene cluste
The identification of a single, early marker for full developmental potential of induced pluripotent stem (iPS) cells ha......
Introduction: Diabetes mellitus (DM), a metabolic disorder, is known to be highly prevalent in people aged 40 - 60 years......
Introduction: Diabetes mellitus (DM), a metabolic disorder, is known to be highly prevalent in people aged 40 - 60 years......
Here we propose that the rejuvenation of leukocytes with iPSC technology in vitro and transfusion of cancer cellresistan......
Here we propose that the rejuvenation of leukocytes with iPSC technology in vitro and transfusion of cancer cellresistan......
‘#赢i蠢囊!”蛰哪’:菇、籍旌翳鬻鬻孽攀繁震誊鬻藜囊i燃黼蒸《瓣≮舔黼媾鬻戮蠢器搿黼搿群∞ij;.I.._iⅥ.^鲤l黼麟鬻鬻m黼薹需麓......
虎(Panthera tigris)是全球遗传资源多样性保护的旗舰物种。在生态系统中,是食物链的顶级掠食者。东北虎(Panthera tigris altaica......
目的:1.完善hiPSC诱导为肝样细胞的培养技术2.建立hiPSC诱导而来的肝样细胞的氧化损伤模型3.探讨中药单体龙胆苦苷及黄芩素对于hiP......
猪干细胞在育种、人类医学和生物学研究等方面具有重要价值,但目前对猪干细胞多能性建立、维持的特异性调控机制还缺乏足够的认识......
自2006年Takahashi和Yamanaka报道生成诱导多能干细胞(induced pluripotent stem cells,iPSCs)以来,多能干细胞领域进入了前所未有......
目的探讨遗传校正后的β-地中海贫血患者特异性iPSCs在SCID移植小鼠中的功能。方法将遗传校正的iPS细胞移植入SCID小鼠,移植6周后,......
背景与目的诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征,......
<正>通过基因转染的方式将已分化的体细胞重编程为诱导性多潜能干细胞(induced pluripotent stem cells,iPSCs)是近年来干细胞领域......
