Reprogramming相关论文
In vertebrates,perception of sound,motion,and balance is mediated through sensorineural hair cells and spiral ganglion n......
Reprogramming of somatic cells to induced pluripotent stem cells rewrites the code of cell fate at the chromatin level.Y......
Oct4 heterodimerizes with Sox2 to direct a gene expression program establishing pluripotency.Oct4 also possess a lesser-......
Islet cell replacement therapy represents a promising approach for the cure of type 1 diabetes if autoimmunity to β cel......
Injuries to the central nervous system lead to irreversible neuronal loss.Neural regeneration from endogenous cells coul......
Hepatocellular carcinoma(HCC)is one of the most prevalent cancers worldwide,accounting for approximately 75%-85%of prima......
Somatic cell nuclear transfer(SCNT)is a unique approach to reprogram fully differentiated nuclear to totipotent stat......
直接从病人体内获得多能干细胞是再生医学研究的最终目标之一。将体细胞转化为多能干细胞的再程序化方法已经被广泛研究。本文综述......
小分子化合物-丙戊酸（valproic acid,VPA）作为组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitors,HDACIs）,能够有效促进体细胞重......
Objective:To compare the expression levels of pluripotent genes among incomplete reprogrammed colonies and induced pluri......
BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two ma......
Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into m
Background:Motor neuron degeneration or loss in the spinal cord is the characteristic phenotype of motor neuron diseases......
心肌病多伴有心力衰竭和顽固性心律失常甚至心源性猝死(sudden cardiac death,SCD),严重危及患者生命.尽管心肌病动物模型的建立为......
目的 探讨巴马小型猪胎儿成纤维细胞重编程为诱导多能性细胞的方法.方法 应用经典的逆转录病毒介导方法,将Oct4,Sox2,c-Myc和Klf4......
通过特殊的技术将体细胞重编程为具有自我更新能力和多向分化潜能的细胞,这种细胞叫做诱导多能干细胞(induced pluripotent stem c......
Pluripotent stem cells (PSCs), characterized by being able to differentiate into various types of cells, are generally r......
,Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcri
Human liver or hepatocyte transplantation is limited by a severe shortage of donor organs.Direct reprogramming of other ......
,Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatr
Cellular reprogramming allows for the de novo generation of human neurons and glial cells from patients with neurologica......
Generation of unlimited functional pancreatic β cells is critical for the study of pancreatic biology and treatment of ......
While human induced pluripotent stem cells (hiPSCs) have promising applications in regenerative medicine,most of the hiP......
With their capability to undergo unlimited self-renewal and to differentiate into all cell types in the body,induced plu......
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,Overcoming barriers to the clinical utilization of iPSCs: reprogramming efficiency, safety and qual
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Reprogramming cell fates towards pluripotent stem cells and other cell types has revolutionized our understanding of cel......
Sialylation is involved in cell fate decision during development, reprogramming and cancer progressi
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important m......
Single-cell bisulfite sequencing (scBS-seq) was developed to assess DNA methylation heterogeneity in human and mouse.How......
,Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embr
Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with num......
Breakthroughs in cell fate conversion have made it possible to generate large quantities of patient-specifc cells for re......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
In recent years, it has become consumedly clear that changing of epigenetic modification is essential during both early ......
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为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
诱导性多能干细胞(iPSCs)技术能够将已分化的体细胞反转为多能细胞,因其不存在伦理、排斥等问题,在再生医学领域具有广阔的应用前......
Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
急性心肌梗死的发病率逐年上升,通过重编程细胞移植,可以促进梗死区心肌细胞再生、防治心室重构和改善心功能.但重编程效率低下,如......
非编码RNA(noncoding RNA ，ncRNA)是一类大量存在于基因组中的不参与蛋白质编码的核苷酸序列，其绝大多数长度>200 nt，称为长链非编码R......
In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facil......
Generation of patient-specific pluripotent stem cells and directed differentiation of embryonic stem
Embryonic stem(ES) cells are pluripotent cells that can give rise to derivatives of all three embryonic germ layers. Due......
诱导多能干细胞（ iPSCs）因其独特优势在再生医学领域具有广泛的应用前景。近年来，一系列的研究发现染色质修饰因子对于干性的维持和促......
人类诱导多能性干细胞(iPS细胞)的出现被誉为生命科学领域里新的里程碑,它建立了一种全新的、相对易操作而较稳定的体细胞核重编程......
The recent progress in derivation of pluripotent stem cells(PSCs)from farm animals opens new approaches not only for rep......
在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习......
2006年Takahashi研究小组成功地将小鼠的胚胎成纤维细胞和鼠尾成纤维细胞重编成为诱导性多能干细胞（iPSC）,开创了体细胞重编程的全新......
供体细胞的不完全重编程是克隆动物成功率低的主要原因。本研究旨在探讨组蛋白去乙酰化酶抑制剂Scriptaid对牦牛（Bos grunniens）成纤......
Hepatocellular carcinoma(HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite t......
