人类肿瘤抗原的鉴定一直是肿瘤免疫研究的热点之一。 90年代以来 ,CTL筛选法、重组cDNA表达文库的血清学分析法 (SEREX)、多肽洗脱法等鉴定方法的出现 ,极大地促进了这一领域的进展。现已从分子水平鉴定出多种人类肿瘤抗原 ,这不仅丰富了人们对肿瘤免疫分子机制的认识 ,而且促进了新的肿瘤免疫治疗方法的发展。 The identification of human tumor antigens has been one of the hot spots in tumor immunology research. Since the 1990s, the emergence of identification methods such as CTL screening, serological analysis of recombinant cDNA expression libraries (SEREX), and peptide elution methods has greatly promoted the progress in this area. A variety of human tumor antigens have been identified at the molecular level. This not only enriches people’s understanding of the molecular mechanism of tumor immunity, but also promotes the development of new tumor immunotherapy methods.