论文部分内容阅读
目的探索非糜烂性反流病(NERD)夜间有胃灼热感症状的患者用药方案。方法将广东省茂名市中医院和中山医科大学附属第一医院2002-02~2004-0854例经质子泵抑制剂治疗仍发生夜间胃灼热感症状的NERD患者随机分为3组,每组18例,在每日口服2次奥美拉唑每次20mg的基础上,分别于夜间睡前加服奥美拉唑20mg、法莫替丁40mg和法莫替丁40mg加阿普唑仑0.4mg,疗程1周。比较治疗后各组夜间有胃灼热感症状的程度、夜间pH<4的时间百分比和NAB的发生率。结果奥美拉唑组夜间pH<4的时间百分比和NAB发生率均较高(P<0.01和P=0.014),法莫替丁组和联用阿普唑仑组间差异无统计学意义(P=0.898和P=0.717);法莫替丁组平均夜间有胃灼热感症状的VAS总积分低于奥美拉唑组(P=0.025),但高于联用阿普唑仑组(P=0.015)。结论阿普唑仑能帮助法莫替丁减少NERD夜间有胃灼热感症状。
Objective To explore the medication regimen for patients with heartburn symptoms at night during non-erosive reflux disease (NERD). Methods A total of 18 patients with NERD who suffered from heartburn symptoms at night from 2002-02 to 2004-0854, Maoming Hospital of Traditional Chinese Medicine and the First Affiliated Hospital of Sun Yat-sen University from April 2002 to April 2004 were enrolled in this study. , Oral Omeprazole 2 times a day on the basis of 20mg each time, respectively, at night before going to bed plus omeprazole 20mg, famotidine 40mg and famotidine 40mg plus alprazolam 0.4mg, Treatment for 1 week. The degree of heartburn symptoms, the percentage of time of nighttime pH <4, and the incidence of NAB were compared between the groups after treatment. Results The omeprazole group had a significantly higher percentage of nocturnal pH <4 and NAB incidence (P <0.01 and P = 0.014). There was no significant difference between the famotidine group and the alprazolam group (P = 0.898, P = 0.717). The VAS scores of average night heartburn symptoms in the famotidine group were lower than those in the omeprazole group (P = 0.025), but higher than those in the alprazolam group = 0.015). Conclusion Alprazolam can help famotidine reduce heartburn symptoms of NERD at night.