目的 探讨胰十二指肠切除术后胰瘘的预防及治疗措施。方法 回顾分析我院183例胰十二指肠切除术,按年份将本组资料分为前6年和后4年两组,其中后组改进了术式,提高了综合治疗手段。结果 后组的胰瘘发生率及死亡率较前组明显降低(P<0.01)。结论 充分的术前准备、熟练的手技、优选良好的术式、术后密切监护能降低胰瘘的发生率和死亡率。 Objective To investigate the prevention and treatment of pancreatic fistula after pancreatoduodenectomy. Methods Retrospective analysis of 183 cases of pancreatoduodenectomy in our hospital. According to the year, the data of this group were divided into two groups: the first 6 years and the last 4 years. Among them, the latter group improved the surgical procedure and improved the comprehensive treatment. Results The incidence and mortality of pancreatic fistula in the latter group were significantly lower than those in the former group (P<0.01). Conclusion Adequate preoperative preparation, skilled hand-craftsmanship, good-preferred surgery, and close postoperative care can reduce the incidence and mortality of pancreatic fistula.