目的 :对双脱氧脱氢核苷的合成进行了研究。方法 :以 2′ 脱氧核苷为原料 ,先用甲磺酰氯 (MsCl)将 3′5′ 位羟基保护 ,然后在NaOH水溶液中形成 3′5′ 0 环状物 ,再与叔丁醇钾 (t BuOK)作用生成 2′,3′ 二脱氧 2′,3′ 二脱氢核苷化合物。结果 :合成了 2′ ,3′ 二脱氧 2′,3′ 二脱氢尿苷 (总收率 3 4 .4 % )及 2′,3′ 二脱氧 2′3′ 二脱氢胸苷 (总收率 52 .3 % )。结论 :产品经紫外可见光谱 ,质谱及核磁共振谱表征 ,结构确认 ,说明用此法合成嘧啶类双脱氧脱氢核苷是可行的。 OBJECTIVE: To study the synthesis of dideoxy-dNucleosides. Methods: The 2’-deoxy nucleoside was used as a starting material to protect the 3’5 ’hydroxyl with methanesulfonyl chloride (MsCl), then the 3’5’0 cyclic product was formed in NaOH aqueous solution and then reacted with potassium tert-butoxide t BuOK) to generate 2 ’, 3’ dideoxy 2 ’, 3’ didecyl nucleoside compounds. Results: The synthesis of 2 ’, 3’ dideoxy 2 ’, 3’ dideoxyuridine (total yield 34.4%) and 2 ’, 3’ dideoxy 2’3 ’ Yield 52.3%). Conclusion: The product is characterized by UV-vis spectrum, mass spectrum and 1H-NMR spectrum, and the structure is confirmed. It is feasible to synthesize pyrimidine dideoxynucleoside by this method.