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目的:探讨蛋白酶激活受体-2(PAR-2)在子宫内膜异位症组织中的表达及意义。方法:应用SP免疫组织化学法检测30例异位子宫内膜、10例正常子宫内膜的PAR-2表达。结果:PAR-2在子宫内膜上皮细胞和间质细胞中均有表达。异位子宫内膜内PAR-2呈强阳性表达;正常子宫内膜内PAR-2呈弱表达。图像分析结果显示异位子宫内膜与正常子宫内膜PAR-2表达的平均光密度及阳性面积比分别为0.221 4±0.010 8、0.058 1±0.010 2和0.135 1±0.032 1、0.062 3±0.011 2。两组间比较,差异有显著意义(P<0.01)。结论:PAR-2可能在子宫内膜异位症的发生发展过程中扮演重要角色;PAR-2有可能成为临床治疗子宫内膜异位症的新的研究靶点。
Objective: To investigate the expression and significance of protease-activated receptor-2 (PAR-2) in endometriosis. Methods: SP-immunohistochemistry was used to detect the expression of PAR-2 in 30 cases of ectopic endometrium and 10 cases of normal endometrium. Results: PAR-2 was expressed in both endometrial epithelial cells and stromal cells. Ectopic endometrium PAR-2 was strongly positive expression; normal endometrial PAR-2 was weakly expressed. The results of image analysis showed that the average optical density and positive area ratio of PAR-2 expression in ectopic endometrium and normal endometrium were 0.221 4 ± 0.010 8,0.058 1 ± 0.010 2 and 0.135 1 ± 0.032 1, 0 062 3 ± 0.011 2. The difference between the two groups was significant (P <0.01). CONCLUSIONS: PAR-2 may play an important role in the development of endometriosis. PAR-2 may be a new target for clinical treatment of endometriosis.