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虽然在风湿病早期肾小球性蛋白尿不常见,但因病变对肾脏的直接作用或使用肾毒性药物,故在疾病进展过程中可出现肾小球性蛋白尿。近曲小管机能改变是肾脏对毒性刺激反应的敏感指标,这种肾小管机能障碍表现为尿低分子量蛋白质增加,常规尿检查方法通常不能检出。本文报告一组严重关节炎患者的近曲小管机能的研究结果。 87(男34,女53)例患者中类风湿性关节炎43例,骨关节病17例,强直性脊椎炎9例,血清阴性的多关节炎6例,其他疾病12例。于入院后未接受治疗
Although glomerular proteinuria is uncommon early in rheumatism, glomerular proteinuria can occur during disease progression due to the direct effects of disease on the kidneys or the use of nephrotoxic drugs. Proximal convoluted tubule function changes are sensitive indicators of renal toxicity response, which is manifested by an increase in urinary low molecular weight proteins and routine urine tests that are usually undetectable. This article reports the results of a study of proximal convoluted tubule function in a group of patients with severe arthritis. There were 43 cases of rheumatoid arthritis, 17 cases of osteoarthritis, 9 cases of ankylosing spondylitis, 6 cases of seronegative polyarthritis and 12 cases of other diseases in 87 (male 34, female 53) patients. Not admitted to hospital after treatment