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虽然肾小球性蛋白尿在早期风湿病中少见,然它系一种进展性病变的并生症,系某疾病对肾脏的直接作用或肾毒性药物作用或两者协同作用所致。近曲小管功能的改变为肾脏对各种毒素刺激反应的敏感指数。肾小管功能障碍显示尿中低分子蛋白量增加,一般不能用常规尿分析检出。作者报告对住入地方风湿病中心的87例严重关节患者作了研究。病例,方法和结果:从87例患者(男性34例,女性57例)中随机收集的10ml尿标本,其中43例为类风湿性关节炎,17例骨关节病,9例关节强硬性脊椎炎,6例血清阴性的多关节炎和12例其他疾病,入院后即刻收集尿标本,通常在药物治疗或物理疗法控制
Although glomerular proteinuria is rare in early rheumatism, it is a progressive disease of the sytem, a direct effect of a disease on the kidney or nephrotoxic drugs or synergistic effect between the two. Changes in proximal convoluted tubule function are sensitive indices of renal response to various toxins. Tubular dysfunction shows that the amount of low molecular weight protein in urine increases, generally can not be detected by routine urine analysis. The authors report on 87 patients with severe joint disease admitted to a local rheumatology center. CASE, METHODS AND RESULTS: Ten ml of urine samples were randomly collected from 87 patients (34 males and 57 females), of whom 43 were rheumatoid arthritis, 17 osteoarthritis and 9 ankylosing spondylitis , 6 cases of seronegative polyarthritis and 12 other diseases. Urine samples were collected immediately after admission and were usually controlled by pharmacotherapy or physiotherapy