论文部分内容阅读
关于甲状腺疾病与风湿病的关系,争论颇多,为此作者进行了三项研究,以期进一步评价两者的关系。一、甲状腺疾病治疗期间是否发生肌肉骨骼症状:观察150例患者(132例突眼性甲状腺肿、14例原发性粘液水肿及4例桥本氏病)在甲状腺疾病治疗期间肌肉骨骼症状的发生情况,其中17例(11%)发生清晨关节僵硬、肩带疼痛和无力;而对照组100例其他疾病恢复期患者仅3例(3%)有类似症状。二、第二线药物(如青霉胺)治疗引起的类风湿病活动性改变是否伴有甲状腺功能变化:测定16例新近发病的类风湿性关节炎(RA)患者在青霉胺治疗的头6个月期间的甲状腺功能,包括血清甲状腺素、三碘甲腺原氨酸和促甲状腺激素。其中11例在此期间 RA活动性有明显改善,但甲状腺功能参数无显著改变。三、在甲状腺疾病合并 RA 患者中甲状腺功能障
On the relationship between thyroid disease and rheumatism, a lot of controversy, for which the author conducted three studies, with a view to further evaluate the relationship between the two. First, the treatment of thyroid disease during the occurrence of musculoskeletal symptoms: observed in 150 patients (132 cases of sudden goiter, 14 cases of primary myxedema and 4 cases of Hashimoto’s disease) in the treatment of muscular and skeletal symptoms of thyroid disease occurred Seventeen (11%) had early morning joint stiffness, shoulder pain and weakness, whereas only three (100%) of the 100 patients with convalescent disease in the control group had similar symptoms. Second, the second line of drugs (such as penicillamine) treatment-induced rheumatoid activity changes associated with thyroid function changes: determination of 16 cases of newly-occurring rheumatoid arthritis (RA) in patients with penicillamine head 6 Thyroid function during the months, including serum thyroxine, triiodothyronine and thyrotropin. Among them, RA activity was significantly improved in 11 cases during this period, but there was no significant change in thyroid function parameters. Third, thyroid disease in patients with thyroid dysfunction in patients with RA