MUC1相关论文
目的:对比无症状HIV感染者、AIDS期患者及健康者三组人群肠粘膜组织病理学及肠粘膜粘蛋白1（MUC1）及粘蛋白2（MUC2）表达水平的差异。探究......
黏蛋白1（mucin 1,MUC1）是黏蛋白家族中最容易被识别的跨膜蛋白，在乳腺癌细胞中过度表达且糖基化水平明显降低，并在乳腺癌发生发展中起......
唾液腺恶性肿瘤是头颈部肿瘤的重要组成部分,其中最常见、最典型的唾液腺恶性肿瘤是腺样囊性癌（adenoid cystic carcinoma,AdCC）和黏......
背景在全世界范围内,肺癌（lung cancer,LC）的发病率仍然在持续上升,肺癌已经是全球发病率最高、死亡人数最多的恶性肿瘤,目前主要的......
目的:MUC1是调控胰腺癌代谢的重要蛋白。甘露糖被报道具有抑制肿瘤细胞糖代谢的作用。本研究为了探索MUC1调控胰腺癌代谢的机制,以......
学位
肿瘤对化疗的耐药是肿瘤复发和导致患者死亡的主要原因,是肿瘤治疗中普遍存在的瓶颈问题。糖蛋白MUC1在人类70%肿瘤内异常高表达,......
近几年来,随着免疫学的进展,肿瘤与免疫之间的关系不断被揭示,肿瘤免疫治疗已经成为除手术、化疗外最重要的治疗手段。肿瘤多肽疫......
目的:基于Crispr/Cas9基因编辑技术对MUC1基因进行敲除,利用短发夹RNA（sh RNA）技术对MUC1基因表达进行沉默,探究MUC1对人三阴性乳腺......
Enhanced glucose metabolism is one of the hallmarks of pancreatic cancer.MUC 1,a transmembrane protein,is a global regul......
目的:MUC1是调控胰腺癌代谢的重要蛋白。甘露糖被报道具有抑制肿瘤细胞糖代谢的作用。本研究为了探索MUC1调控胰腺癌代谢的机制,以......
学位
Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy a
Quantum dot (QD) have been extensively explored for in vitro and in vivo imaging due to their superior fluorescence prop......
Chemotherapy is a primary treatment for metastatic cancer,but its efficacy is often limited by the adverse effects of cy......
Expression and Function of MUC1 in Early Pregnant/Non-pregnant Sheep Uterus Manipulated by Artificia
Mucin 1 (MUC-1) is a cell surface glycoprotein with a previously described anti-adhesive role involved in different aspe......
目的 MUC1 是粘蛋白家族成员之一，越来越多的研究证实MUC1 在乳腺癌、肺癌、卵巢癌、前列腺癌、胰腺癌等多种腺癌和某些血液系统恶......
目的 MUC1 is a membrane-tethered glycoprotein expressed in various mucosal epithelial cells as well as hematopoietic cel......
MUC1 enhances the metastasis of HCC through phosphorylation of smad2 at both linker and COOH-termina
Background: Mucin 1 (MUC1) is a transmembrane glycoprotein which plays a key role as an oncogene in the tumorigenesis of......
Mucin1 mediates autocrine TGF-β signaling through activating JNK-AP1 pathway in human hepatocellular
Our previously study found that the oncogene mucinl (MUC1) silencing decreased TGF-β signaling by global gene expressio......
目的：建立SYBR GREEN 荧光定量聚合酶链反应法检测外周血循环肿瘤细胞中MUC1 基因表达水平，探讨其在乳腺癌诊断和治疗监测中应用。......
目的：探讨荧光定量聚合酶链反应(fluorescence quantitative polymerase chain reaction,FQ-PCR)法检测外周血循环肿瘤细胞(circula......
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目的：膜结合型MUC1作为癌基因可导致正常细胞恶性转化，在乳腺癌、肺癌、胰腺癌等多种腺癌和某些血液系统恶性肿瘤的发生发展中起重要......
MUC1是一种广泛表达于呼吸系统、消化系统和生殖系统等分泌型上皮细胞管腔表面的高分子量糖蛋白,起润滑和保护等作用.但临床研究表......
MUC1 Induces Metastasis in Esophageal Squamous Cell Carcinoma by Upregulating Matrix Metalloproteina
Esophagus squamous cell carcinoma (ESCC) is one of the most deadly malignances because of its high frequency of metastas......
Adoptive cell Therapy using T cells Engineered with Dual Signal-independent Chimeric Antigen Recepto
Objective: Chimeric antigen receptor (CAR)-engineered T cells (CAR-T) can destroy tumor cells expressing targeted tumor-......
In recent years,therapeutic tumor vaccines have attracted great attentions in cancer treatment.[1] MUC1 is a transmembra......
MUC1 Aptamer-Modified DNA Origami as Nanocarrier of Metal Complex for Cervical Cancer-Targeted Thera
Mucin(MUC1)is a glycoprotein that is expressed on the surface of most secretory epithelial cells to boycott toxic chemic......
MUC1粘蛋白是一种高分子量糖蛋白，存在于正常腺细胞和多种癌细胞表面，由于它特有的免疫学特性，即在癌变细胞表面异常、高度表达，具有肿......
Synthetic Two-component Antitumor Vaccines Based on MUC1 Glycopeptide and T-Cell Epitopes from Tetan
MUC1 is a kind of tumor-associated glycoprotein which is extensively O-linked glycosylated and over-expressed on man......
黏蛋白1(MUC1)是一种在腺体肿瘤细胞中过表达的跨模型糖蛋白，胞外区由若干数目可变级联重复序列(VNTRs)构成，每个序列由20 个氨......
当前许多基础和临床资料显示，免疫靶向治疗有望改善恶性血液疾病的治疗效果。粘蛋白MUC1作为最早被发现的人类肿瘤特异性T细胞识别......
Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effe
Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promi......
Esophagus squamous cell carcinoma(ESCC) is one of the most aggressive malignant tumors in the world. Our previous data d......
目的:制备携抗MUCI单克隆抗体的超声造影剂微泡,并评价其体外寻靶能力。方法:采用异型双功能交联剂将小鼠抗MUCI单克隆抗体与超声......
目的探讨MUC1对骨髓来源抑制细胞(MDSC)产生的影响。方法将过表达MUC1细胞(B16-MUC1)和对照细胞(B16-neo),接种于C57BL/6小鼠皮下,......
目的探讨肿瘤抗原MUC1抑制骨髓来源抑制细胞(myeloid-derived suppressor cell,MDSC)产生的机制。方法分离C57BL/6小鼠股骨骨髓细......
目的探讨子痫前期患者胎盘组织中缺氧诱导因子-1α(Hypoxia-inducible factors-1α,HIF-1α)、黏蛋白1(Mucin1,MUC1)和基质金属蛋......
MUC(mucin)即粘液基因蛋白,为粘液凝胶的主要成分,广泛存在于胃肠道、呼吸道、生殖道等上皮细胞的表面,由上皮的特殊细胞合成和分......
目的 检测MUC1、ER和PR在乳腺癌中的表达 ,探讨其在乳腺癌的诊断和预后评估中的意义。方法 采用免疫组化方法检测了 86例乳腺癌......
一、材料和方法选取哈尔滨医科大学附属第三医院 1989年 1月～ 2 0 0 3年 6月期间卵巢上皮性肿瘤手术切除标本 90例。其中浆液性肿瘤......
粘蛋白 1(MUC1)是一种分布于腺上皮细胞的跨膜糖蛋白 ,在保护细胞免受外界不良因素的影响及介导细胞信号传导方面具有重要的生物学......
目的 MUC1在胆囊癌组织中的表达及临床病理意义.方法 采用免疫组织化学PV6000二步法检测MUC1在胆囊癌及癌旁组织中的表达情况,并结......
AIM: To investigate the relation between MUC1 expression,distribution, and prognosis in hepatocellular and cholangiocarc......
Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastr
AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to......
粘蛋白(mucin)是一类以高度O-糖基化和含有连续重复肽序列为特征的高分子量糖蛋白,在体内分布广泛,存在于多种上皮组织,有分泌型和......
目的通过生物信息学分析具核梭杆菌(Fusobacterium nucleatum,F. nucleatum,Fn.)对结直肠癌(colorectal cancer,CRC)差异表达基因(......
