ABCB1相关论文
目的 系统性评价ABCB1基因多态性对慢性粒细胞白血病及胃肠道间质瘤患者治疗药物伊马替尼血药浓度水平的影响，为临床个体化用药提供......
背景:胆管癌（CCA）是肝胆肿瘤中最常见、最严重的恶性肿瘤之一。中国是全世界范围内胆管癌的高发地区。胆管癌是一类异质性极高的肿瘤......
目的 系统评价ABCB1 C3435T基因多态性与急性淋巴细胞白血病(acute lymphoblastic leukemia, ALL)儿童患者接受甲氨蝶呤(methotrex......
目的 探究CYP2C19、GPIa、ABCB1基因检测在伴发糖尿病的卒中患者抗血小板治疗作用.方法 分析河南省人民医院神经内科2019年2月至20......
肿瘤对化疗的耐药是肿瘤复发和导致患者死亡的主要原因,是肿瘤治疗中普遍存在的瓶颈问题。糖蛋白MUC1在人类70%肿瘤内异常高表达,......
目的:研究腺苷三磷酸结合盒转运体B1 (ABCB1)基因编码区C1236T多态性与癫痫耐药的联系.方法:在PubMed、Springlink、Web of Scienc......
癌症严重威胁人类健康,抗肿瘤药物的研究发是当今生物医药研究领域的重中之重。虽然目前新型抗肿瘤药物的研究已取得了巨大进展,但......
目的:系统评价核糖核苷酸还原酶1亚基(RRM 1)(-37 C>A)/(-524 T>C)、多药耐药转运蛋白ATP结合盒式跨膜转运蛋白超家族B亚群1(ABCB1......
目的 探讨阿帕替尼通过调控ABCB1逆转非小细胞肺癌(NSCLC)紫杉醇(PTX)耐药性的相关机制.方法 肺腺癌细胞株A549购自中国科学院生物......
Polyoxypregnanes as safe,potent,and specific ABCB1-inhibitory pro-drugs to overcome multidrug resist
Multidrug resistance(MDR)mediated by ATP binding cassette subfamily B member 1(ABCB1)is significantly hindering effectiv......
卵巢癌（Ovarian cancer）作为妇科常见的恶性肿瘤,发病率及病死率均居前列,对女性的生命健康造成严重威胁,由于其发病隐蔽的特点,让许......
Another role of a novel compound ERK5-IN-1 in anti-tumor potential:reversing multi-drug resistance m
目的 The expression of ABC transporters leads to multi-drug resistance which isconsidered to be blamed for chemotherapy ......
15-oxospiramilactone reverses multidrug resistance in the Human Renal Cell Carcinoma by targeting AB
Background: Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for Human Renal Cell Carcinoma......
探讨ABCB1和NFKBIA的基因多态性对中国肾移植患者术后早期环孢素A(CsA)血药浓度的影响.共有101名肾移植术后服用环孢素A的患者被纳......
目的：系统评价患者长期或大剂量服用糖皮质激素后发生股骨头坏死与ABCB1C3435T和ABCB1G2677T/A基因多态性的关系,以期为其安全使用......
目的：探讨中国汉族癫痫患者卡马西平单药或合并用药治疗中,CYP3A4/3A5、ABCB1基因多态性对卡马西平(CBZ)及10,11-环氧卡马西平(CBZ-......
目的 了解美沙酮血药浓度及美沙酮疗效相关基因μ阿片受体基因(OPRM1)及多药耐药1基因(ABCB1)对美沙酮维持治疗疗效的影响。方法 ......
Cancer cells were transiently protected from chemotherapeutical agent via instant intercellular tran
Intercellular exchange of membrane proteins through various incompletely defined mechanisms is a novel cellular cross-ta......
ABCB1-mediated multidrug resistance (MDR) remains a major obstacle to successful chemotherapy in ovarian cancer. Herein,......
Multidrug resistance remains a major impediment to successful chemotherapy.In clinical chemotherapy,some patients often ......
Effect of abemaciclib(LY2835219)on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexp
Multidrug resistance(MDR)is the major obstacle of the success in cancer chemotherapy.The overexpression of ATP-binding c......
多药耐药性(multidrug resistance,MDR)是肿瘤成功化疗的主要障碍.ABC 转运泵如ABCB1、ABCC1、ABCG2 过表达是介导MDR 的主要原因.......
Effect of ABCB1 rs12720464 and rs1055302 polymorphisms in Chinese patients on the time-course of act
Objective: To determine whether ABCB11 gene polymorphisms affect the time-course of action of rocuronium in Chinese pati......
目的 尿苷二磷酸葡糖醛酸转移酶 lAl(uridine diphosphate-glucuronate transferaselAl,UGTlAl)是伊立替康活性代谢物(SN-38)的主......
Cancer cells were transiently protected from chemotherapeutical agent via emergency intercellular tr
Background: Multidrug resistance (MDR) is a major impediment to the overall success of chemotherapy in clinical oncology......
Acerinol, a cyclolanstane triterpenoid from Cimicifuga acerina,reverses ABCB1-mediated multidrug res
The ABCB1 transporter is one of the members of ATP-binding cassette superfamilies,frequently overexpressed in cancer cel......
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目的探讨细胞色素P450酶3A5(CYP3A5)6986A>G(rs776746)和ATP结合蛋白亚科B运载体1基因(ABCB1)3435C>T (rs1045642)两个基因的多态......
目的探讨ABCB1多态性与进展期胃癌患者紫杉醇治疗敏感性的关系。方法回顾性收集2008年12月至2013年4月间北京大学肿瘤医院连续收治......
A novel mechanism of transient cellular self-protection against chemotherapeutical drugs via stimula
ABCB1 (P-gp/MDR1/ABCB1),one of the most important mediator of multidrug resistance (MDR),has been observed as a resu......
Multidrug resistance (MDR) caused by human ABCB1 (P-glycoprotein /MDR1) is one of the major obstacles in chemotherapy.To......
目的探讨ABCB1基因C1236T单核苷酸多态性在中国儿童中的分布及其与抗癫药物反应性的关系。方法研究对象180例,包括健康对照组80......
目的研究ATP结合盒转运蛋白B1(ABCB1)基因C1236T多态性在皖南地区汉族自然人群中的频率分布及与血脂异常者各项血脂指标的相关性。......
目的研究色瑞替尼(Ceritinib)增强ABCB1过表达白血病多药耐药的作用及机制。方法采集白血病骨髓样本,白血病细胞的分离、复苏及冻......
目的:探讨P-糖蛋白(P-gp)活性和所介导的甲磺酸伊马替尼胞内累积量及药物跨膜渗透性的影响。方法:将构建的ABCB1 1199G/wt和1199A/......
Association of Single Nucleotide Polymorphisms of ABCB1, OPRM1 and COMT with Pain Perception in Canc
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目的探讨hsa_circ_0005986对人宫颈癌细胞(SiHa细胞)增殖和转移的影响。方法 2021年3月从研域生物技术(上海)有限公司购入人宫颈癌......
Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistanc
Cisplatin resistance is a major challenge for bladder cancer(BC).Evidence indicates that exo-some derived from cancer-as......
目的 氯吡格雷能够降低血小板的聚集,起到抗血小板的作用。本研究旨在探讨ABCB1基因多态性与CR之间的关系。方法 应用VerifyNow P2......
研究目的:探究ABCB1和ABCG2介导帕比司他耐药的作用机制。研究内容:肿瘤细胞的多药耐药(multidrug resistance,MDR)是恶性肿瘤诊疗......
第一部分内蒙古地区汉族耐药癫痫患者ATP结合蛋白家族ABCB1和ABCC2基因多态性研究背景(1)癫痫为多种病因引起的长期反复发作性大脑......
