aptamer相关论文
目的:恶性肿瘤是威胁人类健康的重大疾病。近年来,肿瘤免疫治疗已经成为肿瘤治疗领域的研究热点。阻断PD-1/PD-L1通路可减少免疫抑......
Development of a Label-Free Colorimetric Aptasensor with Rationally Utilized Aptamer for Rapid Detec
Okadaic acid (OA) is a typical marine toxin with strong toxicity causing diarrheic shellfish poisoning (DSP). Aptamers s......
Cells are the basic structural and functional units of organisms.Dynamic analysis and manipulation of specific component......
An intriguing electrochemical impedance aptasensor based on a porous organic framework supported sil
Porous organic frameworks (POFs) are excellently stable porous materials,which can be employed as host platforms to supp......
Artful union of a zirconium-porphyrin MOF/GO composite for fabricating an aptamer-based electrochemi
More and more attentions have been focused on design and synthesis of novel metal-organic framework/graphene oxide (MOF/......
Aptamer-labeled Mesoporous Silica Nanoparticles loaded with doxorubicin used for cancer metastasis p
The capture of circulating tumor cells(CTCs)from blood is highly important but challenging in cancer diagnosis and thera......
Due to tunable localized surface plasmon resonance, gold nanorods can absorb and scarer strongly light in the near-infra......
Aptamers are single-stranded oligonucleotides binding to target molecule with high specificity and affinity.Compared wit......
Functionalized PLGA-PEG nanoparticles conjugated with aptamer and gadolinium for MRI imgaing and dru
Magnetic resonance imaging(MRI)is one of the most powerful clinical techniques in cancer diagnosis.Much attention has be......
The Architecture and Biological Function of Dual-Aptamer-Coated-Mesoporous Silica Nanoparticles:Reco
Circulating Tumor Cells(CTCs)are the main reason for cause of cancer metastasis.It is possible to reduce the number of p......
Molecular recognition force spectroscopy study of the interaction between aptamer and human lung ade
Lung cancer is a major cause of cancer related deaths both in the developed and developing nations.Early diagnosis of th......
Merrifield chemistry enabled us to conveniently synthesize oligonucleotide and peptides.In addition, recombinant DNA tec......
Nuclein-targeting liposomes guided by aptamer EpCAM for the delivery of siRNA PD-L1 for malignant tu
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In recent years,exosome has attracted extensive attention of researchers.Result from the studies found that it is relate......
A label-free ultrasensitive fluorescence detection of viable Salmonella typhimurium using enzyme-ind
The harm of Salmonella typhimurium(S.typhimurium)to public health mainly by contaminating fresh food and water emphasize......
Chemotherapy is a primary treatment for metastatic cancer,but its efficacy is often limited by the adverse effects of cy......
A label-free ultrasensitive fluorescence detection of viable Salmonella enteritidis by NMM/G-quadrup
The harm of Salmonella enteritidis(S.enteritidis)to public health mainly by contaminating fresh food and water emphasize......
ProgressInAptamer-MediatedDrugDeliveryVehiclesForBoneCancerTargetingAndItsImplicationsF
Aptamersarenoveloligonucleotideswithflexiblethree-dimensional configurationstorecognizeandbindtheircognatetargetsincludi......
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Development of a dual signal amplification biosensor based on hemin functionalized graphene nanoshee
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Objective To screen aptamers that specifically recognize human bladder cancer cell lines(EJ,T24,BIU87)through cell based......
Aptamer-functionalized peptide H3CR5C as a novel nanovehicle for codelivery of fasudil and miRNA-195
OBJECTIVE In this study,we used a new cationic peptide H3R5 as a reducible vector,aptamer ST21 with specific binding to ......
AS1411 aptamer targets the protein nucleolin,which is over expressed on the surface of certain cancer cells.STAT3 is a s......
The development of efficient and safe drug delivery carriers is one of the most important challenges to overcome for miR......
Intracellular detection of ATP using a molecular beacon based on aptamer covalent conjugated to grap
Objective: In the past few years, aptamer physisorbed on graphene oxide (GO) has emerged as a useful sensing platform In......
Aptamer/polydopamine nanospheres complex based fluorescent biosensor for sensitive and selective det
In this work,based on the high fluorescence quenching efficiency of polydopamine nanospheres(PDANS)and the specific reco......
Biofilms are microbial communities that are attached to a solid surface using extracellular polymeric substances.Motilit......
To reduce the resistance of cancer cells against cisplatin,dry powder inhalation of target siRNA loaded lipid nanopartic......
Study on the prostate cancer-targeting mechanism of aptamer-modified nanoparticles and their potenti
Objective: Ligand-mediated prostate cancer (PCa)-targeting gene delivery is one of the focuses of research in recent yea......
Purpose: To Explore biological functions and preliminary molecular mechanisms of TY04 target multiple myeloma (MM) cell.......
近年来,Aptamer作为一种高亲和力、高特异性的靶向识别分子在生物传感、分子医学等领域受到了广泛关注。特别是由于序列设计灵活、......
Hybrid Approach Combining Boronate Affinity Magnetic Nanoparticles and Capillary Electrophoresis for
Capillary electrophoresis(CE)and magnetic beads have been widely used for the selection of aptamers owing to their effic......
Synthetic genetics is a sub-discipline of synthetic biology that aims to develop xeno-nucleic acid(XNA)polymers that can......
MicroRNA是一类长度约19至23-nt的非编码小RNA,在生命活动中起着重要作用,是潜在的癌症标志物1.本研究中,我们描述了一种microRNA......
Organic-Inorganic Hybrid Silica Monolith Based Covalently Bonded Aptamer Affinity Chromatography Col
Aptamers, generally selected by the SELEX (systematic evolution of ligands by exponential enrichment) approach, are shor......
One of the great challenges in cellular studies is to develop a rapid and biocompatible analytical tool for single-cell ......
Specific Inhibition of Integrin α3β1-Mediated Tumor Metastasis by a Triple Negative Breast Cancer-Ta
In the course of cancer cell metastatic,cell adhesion molecules are essential for transducing intracellular signals resp......
Although considerable clinical attempts on various types of cancers have achieved,photodynamic therapy(PDT)still suffers......
Essential to elucidating fundamental biological processes is first gaining precise and reversible external control over ......
Alzheimer s disease(AD)is one of the most common age-related neurodegenerative diseases in which abundant amyloid β(Aβ......
Aptamer based on-plate microarray for high-throughput and sensitive insulin detection by MALDI-TOF M
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Label-free fluorescent DNA sensor for the detection of Mercury ions based on Ru complex and unmodifi
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灵敏而特异的分子探针设计与构建一直是肿瘤诊断学面临的重要挑战之一.Aptamer作为一类新型靶向识别分子,由于具有亲和力高、特异......
"诊疗一体化"多功能探针可在准确了解病变位置和类型的同时实施治疗,有望在实现疗效最大化的同时将不必要的毒副作用减少到最低[......
Aptazyme is a kind of nucleic acid probes which take advantage of the specific recognition of aptamer and the highly cat......
