MAPKs相关论文
旨在研究蒲公英提取物对内毒素（LPS）诱导小鼠乳腺炎的减轻效应及其机制分析。将小鼠随机分为空白组、模型组、阳性组和蒲公英提取物......
目的 研究胡芦巴碱（trigonelline, TRG）对H2O2诱导的人肝细胞系L02氧化损伤的保护作用及机制。方法 MTT法检测细胞活力；试剂盒法检测L......
背景:结直肠癌是全世界第三大常见的恶性肿瘤,是癌症死亡的第二大常见原因。现代手术技术的发展与化疗和放疗方案在不断改进,但结......
中医药防治帕金森病临床疗效较好，大量药理学研究亦证实中药活性成分及中药复方主要通过调控帕金森病核转录因子-κB（nuclear transc......
研究背景出血性脑卒中是致残率和死亡率非常高的卒中亚型。脑出血后,脑内的血肿激发一系列的反应导致继发性脑损伤和严重的神经功......
Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lac
Guided by cell-based anti-anaphylactic assay,eighteen cage-like monoterpenoid glycosides (1-18) were obtained from the b......
研究背景及目的中暑（heatstroke,HS）是一种危及生命的疾病,特征为暴露在高温环境中或剧烈运动后使核心体温升高超过40℃,出现多器官......
Diaporisoindole B(DPB)是从红树内生真菌Diaporthe sp.SYSU-HQ3的次级代谢产物中分离得到的一种异吲哚类衍生物.前期研究表明DPB......
Discovery of synergistic anti-inflammatory compound combination from herbal formula GuGe FengTong Ta
Multi-components in herbal formulae exert holistic effects in synergistic or additive manners.However,appropriate strate......
To investigate the effect of Yiqi Wenyang (YQWY) decoction on reversing cardiac hypertrophy induced by the transverse ao......
Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κB inflammatory pathway in the neuroprot
Atractylenolide Ⅲ (ATL-Ⅲ),a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae,has revealed a num......
目的 利用小鼠原代单核破骨前体细胞，探讨氨来呫诺(一种TBK1和IKKε抑制剂)对体外破骨细胞分化及功能影响的分子机制。方法 取6-8周......
TGF-bate1associated with increased expression of Connective Tissue Growth Factor to induce Hypertrop
Hypertrophy of ligamentum flavum is one of the key pathomechanisms of lumbar spinal stenosis.TGF-b1 is abundantly expres......
Oridonin inhibits osteoclast formation and ovariectomy-induced osteoporosis by suppressing the MAPKs
Objective.Oridonin, an active diterpenoid compound from Rabdosia rubescens,has effects of anti-tumor,treating multiple m......
背景和目的：中药木鳖子(Cochinchina Momordica Seed,CMS)具有抗癌活性,在我国北方地区被广泛应用于治疗肿瘤患者。......
Preliminary studies have widely investigated the dose-effect relation of "plant-soil-micro" system for R.glutinosa, a ......
p-hydroxylcinnamaldehyde induces the differentiation of B16F1 melanoma cells via a GTP-Rho1-MAPKs pa
Aim of this study: The overall objective of the present study was to understand the differential effect of p-hydroxylcin......
The saponin DT-13 attenuates tumor necrosis factor-a-induced vascular inflammation associated with S
This study aimed to explore the effect of DT13 (25(R,S)ruscogenin10βdglucopyranosyl(1→2)][βdxylopyranosyl(1→3)]βdfu......
The neuroprotective effects of baicalin on ethanol-induced impairment via anti-oxidative and anti-ap
Baicalin is a major bioactive ingredient from the roots of Scutellaria baicalensis Georgi and has various pharmacologica......
1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] inhibits MMP-9 expression by regulating NF-κB an
Hippocampus is a traditional medicine in China,which can be used for treating tumors,aging,fatigue,thrombosis,inflammati......
目的：探讨低氧训练对大鼠骨骼肌HIF-1α MAPKs信号传导途径的影响.方法：六周龄雄性SD大鼠70只,体重160-180g,分笼饲养,每笼5只,自由......
Inhibition of glycopyrronium bromide on cigarette smoke-induced pulmonary inflammation via MAPK/NF-κ
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BAK1-mediated crosstalk of MAPK and CDPK cascades in the regulation of ROS production and cell death
Plant innate immunity generally consists of two branches, pathogen associated molecule patterns (PAMPs)-triggered innate......
Rice MAPK phosphatase IBR5 negatively regulates drought stress tolerance in transgenic Nicotiana tab
The mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are important negative regulators in the MAPK signaling ......
SL4, a chalcone-based compound, induces apoptosis in human cancer cells through activation of ROS/MA
SL4, a chalcone-based compound, exhibits clearly inhibitory effects on HIF-1 and has been shown to effectively suppress ......
Microglia,the resident phagocytes of the CNS,plays an important role in the active immune defense and the progression of......
MAPKs是一类表达于所有真核细胞的丝氨酸/苏氨酸蛋白激酶,主要可以分为四类:ERK,JNK,p38和ERK5。MAPKs除了受上游激酶磷酸化的正调......
细胞表面的外来刺激可引起一系列胞内信号，对促进细胞增值、分化和凋亡起重要的生理作用。而信号转导途径中的某个环节异常，可引起细......
The neuroprotective effects of carvacrol on ethanol-induced hippocampal neurons impairment via the a
[Background] Chronic alcohol consumption causes cerebral impairment, which is associated with oxidative stress and a......
气道慢性炎症和吸烟在慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)的发生、发展过程中不是相互孤立的，而是相互......
目的:检测风湿性心脏病心房颤动患者心房组织中结缔组织生长因子(CTGF)、肝细胞生长因子(HGF)、MAPKs信号通路分子的磷酸化水平,探......
目的 探讨支原体巨噬细胞活化脂肽2（ MALP-2）能否诱导人单核细胞系THP-1产生血红素氧合酶-1（HO-1），并探讨其可能的调控机制。方法体外培......
目的研究钠-钾-氯共转运体1(NKCC1)抑制剂布美他尼(Bumetanide)对脊髓原代少突胶质前体细胞(OPCs)增殖的影响及其机制。方法振摇及......
目的:探究地肤子皂苷Ic抑制头颈癌细胞增殖及作用机制。方法:通过以下方法来探究地肤子皂苷Ic抑制头颈癌细胞增殖及作用机制。(1)......
目的:探讨沙眼衣原体(Chlamydia trachomatis,Ct)CT849蛋白在宿主细胞炎症调节过程中起到的作用及有关机制,为进一步了解Ct致病情......
人类乳腺癌细胞中有天然表达的速激肽受体Neurokinin-1(NK1),该受体被激活后会导致乳腺癌细胞增殖,但是NK1受体是否直接参与了乳腺......
[目的]探讨隐丹参酮对小鼠变应性接触性皮炎(ACD)的影响,并观察其机制是否与Th1,Th2型细胞炎性因子及MAPKs蛋白的作用有关.[方法]......
弓形虫病是一种危害严重的人畜共患性寄生虫疾病,其防治方法一直是医学及兽医学研究的热点课题。桦褐孔菌多糖(IOP)作为传统中药桦......
第一部分:阿司匹林对小鼠颅骨骨溶解模型中骨丢失的抑制作用目的:观察阿司匹林干预钛颗粒诱导的颅骨骨溶解的效果。方法:将小鼠分......
目的:本论文旨在探究番荔枝多糖ASPA80及ASPA80-1对小鼠RAW264.7巨噬细胞和树突状细胞免疫功能的影响及作用机制。方法:1.倒置显微......
目的:瞬时受体电位香草酸亚型1（Transient receptor potential vanilloid 1,TRPV1）是Ca2+高通透性的非选择性阳离子通道,可以被细胞......
高浓度的活性氧（ROS）会引起肿瘤细胞的凋亡,而荜茇酰胺可以被直接递送至肿瘤细胞,选择性增加肿瘤细胞中的ROS水平,从而抑制肿瘤细胞......
勃起功能障碍(erectile dysfunction,ED),又称阳痿,是一种典型的男性性功能障碍疾病,主要以阴茎勃起的启动和维持困难为主要表现,......
受体及其调节肽通常在肿瘤细胞中异常表达,这就使得它们成为潜在的治疗靶点。人血激肽Hemokinin-1是速激肽受体(Neurokinin-1 rece......
