Inhibitor相关论文
33. The Study of Mechanism By Which The Telomerase Template Phosphorothioate Antisense Oligonucleoti
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Coronaviruses (CoVs) are important human and animal pathogens that cause respiratory and gastrointestinal diseases.Porci......
缺血性脑卒中是一种血液循环障碍疾病,可导致严重的神经功能缺损.卒中病人中约有87％的病例为缺血性卒中.神经炎症是中风损伤的主要......
肺纤维化是一种以肺实质重塑和胶原沉积为特征的不可逆性间质性肺病。近年来，不明原因导致的肺纤维化发病率和病死率呈上升趋势，其发......
DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESI
p-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27,HPPD) belongs to the family of Fe(ll)-dependent non-heme oxygenases t......
After harvest, cassava (Manihot esculenta Crantz) storage roots undergo rapid postharvest physio-logical deterioration, ......
Inhibition Mechanism of Hydroxyproline-like Small Inhibitors to Disorder HIF-VHL Interaction by Mole
Protein-protein interac-tions are vital for a wide range of biologi-cal processes.The in-teractions between the hypoxia-......
Angiotensin-converting enzyme inhibitors from plants:A review of their diversity,modes of action,pro
Angiotensin-converting enzyme (ACE) inhibitors are antihypertensive medications often used in the treatment of diabetes-......
背景:已有证据表明,LncRNA-HOTAIR能调节骨髓间充质干细胞中成骨相关基因的表达,但其对脂肪间充质干细胞成骨分化的影响尚未见报道......
NDM-1导致的β-内酰胺类抗生素耐药问题己成为威胁全球公共卫生的重大危机.我们前期经筛选发现(—)-表儿茶素没食子酸酯是一种有效......
Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agen
Anoctamin 1(ANO1)is a kind of calcium-activated chloride channel involved in nerve de-polarization.ANO1 inhibitors displ......
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A Novel Controlled-Release System Based on Horseradish Peroxidase-Gated Mesoporous Silica Nanocontai
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O,O-Dimethyl application of as a new postemergence herbicide 1-(2,4-dichlorophenoxyacetoxy)ethylphos
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Glucose-6-phosphate isomerase is an endogenous inhibitor to myofibril bound serine proteinase of cru
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Objective Signal transducer and activator of transcription(STAT)is an important nucleic acid transcription factor.It is ......
ThePI3K/Akt,p38MAPKandJAK2/STAT3SignalingPathwaysMediatestheProtectionofSO2AgainstAcute
Aim: ThepresentstudyaimtoverifiedtheroleofSO2onlimbI/RinducedALI,andinvestigatewhetherPI3K/Akt,p38MAPKand JAK2/STAT3Path......
Identification of an allosteric small-molecule inhibitor against IDH2/R140Q for the treatment of acu
Objective Mutations in the metabolic genes contribute to the initiation and maintenance of tumors.Isocitrate dehydrogena......
Synergistic effect and Mechanism of E3330 Combination with Vemurafenib in the Treatment of Papillary
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The PI3K/Akt, p38MAPK and JAK2/STAT3 Signaling Pathways Mediates the Protection of SO2 Against Acute
Aim: Sulfur dioxide(S02)is naturally synthesized by glutamate-oxaloacetate transaminase(GOT)from L-cysteine in mammalian......
Novel Histone Deacetylase(HDAC)Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide
Based on the strategy of “multifunctional drugs”,a novel series of phenylsulfonylfuroxan-based hydroxamates with histo......
The selective BACE1 inhibitor Vla reduces Aβ production and ameliorates behavioral deficits in a mou
Aim: We are pursuing potent BACE1 inhibitors in an effort to identify suitable AD drug candidates.Methods: Employing a h......
SETD8/SET8/Pr-SET7/KMT5A is the sole protein lysine methyltransferase(PKMT)that catalyzes the monomethylation of histone......
Most advanced non-small-cell lung cancer(NSCLC)with activating epidermal growth factor receptor(EGFR)mutations(exon 19 d......
The p53 tumor suppressor protein plays a key role in regulation of several important cellular processes,including cell c......
Prokaryotic expression of human histone lysine specific demethylase 2 and its biological significanc
LSD1(also known as KDM1A)is the first identified histone lysine demethylase.It converts mono-or di-methylated histone H3......
Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribo
Aim Nicotinamide phosphoribosyltransferase (NAMPT) plays an important role in cardiocerebrovascular physiopathological p......
A novel accurate method of human protein tyrosine phosphatase 1B inhibitors high-throughput screenin
Aim: A high-throughput screening model was established on 384-well microplate with 50 μL volume in order to screen pote......
Effects of novel triazole-dithiocarbamate based LSD1 selective inhibitors on gastric cancer cell gro
The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well a......
Cardiovascular protection effect of a novel Rho-kinase inhibitor, DL0805-2, and the potential drugga
Aim: Rho/Rho-kinase is an important new target for the treatment of cardiovascular diseases.The aim of this study was to......
Design and synthesis of novel 2-aryl-3-benzyloxy-5-chloro-pyrimidine derivatives as anaplastic lymph
Anaplastic lymphoma kinase(ALK)is a receptor tyrosine kinase(RTK)belonging to the insulin receptor superfamily....
Chitinase-h(Chi-h)is of special interest among insect GH18 chitinases due to its exclusive distribution in lepidopteran ......
Chronic lymphocytic leukemia(CLL)remains the most incurable leukemia.Traditional chemotherapeutic treatments,including a......
Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di......
20-hydroxyeicosatetraenoic acid(20-HETE)as an important metabolism of arachidonic acid(AA).Since it was discovered,it wa......
We discovered in the current study that six side chain-to-side chain cyclic pentapeptides harboring a central Nε-dodecy......
In the current study,we discovered that several N-terminus-to-side chain cyclic tripeptides harboring the catalytic mech......
Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine
Berberine is a traditional medicine that has multiple medicinal and agricultural applications.However,little is known ab......
Study on the modulation of gastric cancer cell growth,invasion and migration by novel potent LSD1 in
The post-translational modifications of histone,e.g.methylation and demythalation,regulate chromatin structure as well a......
Breast cancers are a heterogeneous group of diseases with distinct and complex mechanisms of pathogenesis.1 Triple-negat......
3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuram
OBJECTIVE To explore the structure activity relationship of a series of flavone derivatives with influenza H1N1 neuramin......
A novel inhibitor of human La protein with anti-HBV activity discovered by structure-based virtual s
Background: Over 350 million people worldwide are infected with hepatitis B virus (HBV),a major cause of liver failure a......
The α-helix Stabilization of the HIV-1 Integrase Sequence Based Peptide Inhibitor by the Introductio
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RN1,a novel galectin-3 inhibitor,inhibits pancreatic cancer cell growth in vitro and in vivo via blo
Galectin-3(Gal-3)has been implicated in pancreatic ductal adenocarcinoma(PDAC),and its candidacy as a therapeutic target......
