【摘 要】
：
Breast cancers are a heterogeneous group of diseases with distinct and complex mechanisms of pathogenesis.1 Triple-negative breast cancers(TNBC) form a subgroup of breast cancers with poor prognosis.T
【机 构】
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Program in Chemical Biology,Department of Physiology and Pharmacology,Knight Cancer Institute,Oregon
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Breast cancers are a heterogeneous group of diseases with distinct and complex mechanisms of pathogenesis.1 Triple-negative breast cancers(TNBC) form a subgroup of breast cancers with poor prognosis.TNBCs lack the expression of estrogen receptor(ER),progesterone receptor(PR) or HER2 and no targeted therapies exist.The cyclic-AMP(cAMP) response element binding protein(CREB) is a stimulus-induced transcription factor activated by multiple extracellular signals through phosphorylation.
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