【摘 要】
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Berberine is a traditional medicine that has multiple medicinal and agricultural applications.However,little is known about whether berberine can be a bioactive molecule toward carbohydrate-active enz
【机 构】
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State Key Laboratory of Fine Chemical Engineering,School of Life Science and Biotechnology and Schoo
【出 处】
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中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
论文部分内容阅读
Berberine is a traditional medicine that has multiple medicinal and agricultural applications.However,little is known about whether berberine can be a bioactive molecule toward carbohydrate-active enzymes,which play numerous vital roles in the life process.In this study,berberine and its analogs were discovered to be competitive inhibitors of glycoside hydrolase family 20 β-N-acetyl-D-hexosaminidase(GH20 Hex)and GH18 chitinase from both humans and the insect pest Ostrinia furnacalis.
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